UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...internal medicine in the division of digestive and liver diseases and principal investigator on the grant. ...vascular disease, hypertension, diabetes and fatty liver disease." The Taskforce for Obesity Research at Southwestern (TORS) was initiated by Dr. Gregory Fit...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...y's methods in order to prevent direct invasion of liver cells, thus dramatically lowering liver damage by the vaccine strain. Cerus plans to use this doubly attenuated listeria strain as a platfor...New fruitfly model of diabetes has future implications for pancreatic cell transplantation
...food, insulin notifies muscles, fat cells, and the liver to take up excess sugar in the blood and store it ... between snacks, glucagon notifies the muscles and liver to break down stored energy like glycogen and fat to release as glucose. However, when this finely t...Gene expression in liver tumors and patient prognosis
...is of the gene expression patterns of 91 unrelated liver tumors revealed two distinctive subclasses highly ... to the development of more targeted therapies for liver cancer patients. While gene technology has previously been applied to some specific aspects of...Cell's gatekeeper for ammonia revealed in unprecedented detail
... coma, stem from overexposure to ammonia. Advanced liver failure disrupts central nervous system function when ammonium ion concentrations are elevated, research shows, so the channel's high efficiency is vital. Each channel threads in and out of the cell membrane 11 times and is structured so that no ammo...JCI table of contents: 1 September, 2004
...ress/21946.pdf Immunity in the Balance The liver is a place of contradiction; on the one hand it ha...-reactive substrates called antigens in either the liver cells or the hepatic lymph nodes to examine the mechanisms that mediate these paradoxical activities...APS awards more than $140,000 to minority students of physiology
...is B Virus (HBV) induces apoptosis (cell death) in liver cells. His lab suspects that protein kinase C- (PKC-) and PKC- play an integral role in apoptosis through their interaction with hepatitis B X (HBx), a viral transactivator expressed during HBV infection. They hypothesize that, during HBV infection, ......he master clock, and it takes several days for the liver to catch up with changes in the master clock. Incidentally, the problems related to jet lag and night shift work are often caused by the liver's inability to respond rapidly to changes in the sleep-wake cycle. One key to understanding the intricac...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
...esse Gelsinger -- suffering from a rare hereditary liver disorder died after participating in an experimental gene therapy trial in 1999. In another case, two young boys who received gene therapy for the severe immunodeficiency disorder known as "bubble boy disease" developed leukemia-like symptoms 30 mont...APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
...search focus is the molecular mechanism underlying liver formation (organogenesis). Though the liver is one of the major digestive organs vital to human physiology, the mechanism underlying liver organ...Newcastle scientists get UK's first stem cell license
...he body. They could be directed to grow into, say, liver cells to cure liver disease, nerve cells to allow patients with spinal injury to walk again or nerve cells to overcome t...You are what you eat: New insight into autophagy
...ody stores nutrients in much the same way that the liver and fat tissue do in mammals. Starvation and inhibition of PI3K or TOR induced autophagy in the Drosophila fat body. "While the molecular machinery of autophagy is largely conserved from yeast to mammals, the control of autophagy in multicellular ani......rain and eye, as well in organs such as the heart, liver and pancreas. Cx36 is found in the brain; Cx50 is located in the lens. By specifically blocking them, Cruikshank said mefloquine will be a useful tool for electrical synapse study. "Mefloquine isn't a magic bullet, but it seems to be better than anyt...Commercialization deal boosts hope for new sickle-cell drug
...own products) that can reduce sickling without the liver toxicity and other side effects of the mother drug. These metabolites were used as the backbone for developing a new drug. A private biotechnology company helped Dr. Brugnara and Dr. Jose Halperin (of Harvard Medical School) generate and test nearly ...JCI table of contents, 2 August, 2004
... weeks of life and is the primary cause of chronic liver disease in children. Liver transplant is ultimately the only treatment, as little is known about the underlying pathogenic mechanisms. Individuals with biliary atresia do not all show the same symptoms, but all cases do have inflammatory injury to th...Genetic discovery could dramatically reduce need for liver transplants in children
... disease of infancy and the most common reason for liver transplantation in children. The new treatments could dramatically reduce the number of liver transplants performed on children every year. Jorge Bezerra, M.D., a physician/researcher in the Div...'Smart gene therapy' protects against damage from heart attack
... also can occur in arteries of the kidneys, lungs, liver or the brain, where it leads to stroke, he added. ...rchers injected the gene construct into the heart, liver and skeletal muscle of three rats in the laboratory. Five weeks later, they restricted blood flow to......risk factors for Type 2 diabetes, in which muscle, liver and fat cells become resistant to insulin, causing blood glucose levels to rise and eventually damage nerves and blood vessels. Dr. Roger Davis and colleagues in the Howard Hughes Medical Institute at UMASS Medical School focused their research effo...NIH renews funding for continued Rb2 tumor suppressing gene research at Temple
...ncer in the lungs, the aggression of cancer in the liver and ovaries, the effectiveness of drug therapies against breast cancer, and as a potential prognosticator of prostate cancer. "The grant from NIH is recognition of our hard and creative work on Rb2/p130 over the past 12 years," says Giordano. "Wit...FDA approves VYTORIN, first and only to powerfully reduce LDL cholesterol through dual inhibition
...by inhibiting the production of cholesterol in the liver and blocking the absorption of cholesterol in the ...-lowering medications, called statins, work in the liver to reduce cholesterol production and increase clearance of cholesterol from the bloodstream. VYTORI...