Tag: "livers" at biology news

New materials hold promise for human healing applications

...m to speak. The third material is derived from the livers of pigs and other mammals. "We remove the cells that are part of the liver and are left with only the matrix, something that looks a lot like a honeycomb," Badylak said. "This matrix supports an extremely dynamic population of liver cells, which have...

UCSD researchers create a home for liver cells on a silicon chip

...er devices. Today, five companies have artificial livers in clinical trials worldwide. Intended for patients with end-stage liver disease, these external devices house pig liver cells or cancerous cell lines that act as a bridge to keep patients alive until a donor liver is available for transplant. Maint...

Somatostatin in sexually dimorphic gene expression

...s to a feminized pattern of gene expression in the livers of males, but it has no dramatic effect on the expression pattern in livers of females. Surprisingly, the males and females in this mutant strain maintain their sexually dimor...

Doctors aware of Tylenol-related liver risk - but is the public getting the message?

...ard recommending liver transplants for those whose livers had been damaged by acetaminophen. "It appears that most doctors' knowledge is good, with more than 95 percent of them aware of certain risk factors, though there's still room for improvement," says Robert Fontana, M.D., assistant professor of inter...

Finding of key blood sugar controller could yield new diabetes drugs

... long-sought molecular "switch" that regulates the livers production of glucose, the sugar that fuels the brain but which builds up dangerously in the bloodstream of diabetics because this switch doesnt turn off. The researchers say it may be possible to design new drug treatments for diabetes as a result o...

Men and women drinking equal amounts of alcohol have unequal risks for liver damage

... determine sex-specific expression of genes in the livers of rats chronically fed alcohol. The authors of the study, Gender Differences in Hepatic Gene Expression in Response to Chronic Ethanol Exposure, are P.K. Eagon, Ph.D., M.S. Elm, H.S. Li, G.J. Van Londen, D.C. Whitcomb, and S.D. Tadic, all from ...

Designer animals made easy

...has been used successfully to deliver genes to the livers of mice with haemophilia (New Scientist, 22 November 1997, p 11). But even in culture Sleeping Beauty integrates at a low rate-just 5 to 6 per cent of cells. Tosk says its transposon is about 10 times as efficient, an enormous difference. Of course...

Peripheral 'Swatch' watches are a powerful force in bodys circadian rhythms

...one third the entire mouse genomein the hearts and livers of mice at various points during the day. Mathematical models developed by Wing Wong, Professor of Computational Biology at Harvard School of Public Health, revealed that eight to ten percent were expressed in a markedly circadian rhythm in both the ...

A green tea extract could help alleviate shortage of livers available for transplant

...pular tea could aid in alleviating the shortage of livers available for transplantation. Background Liver t...iver diseases. However, a severe shortage of donor livers strictly limits the use of this life-saving technique. Consequently, many patients die because they ...

U of Minnesota study: Adult bone marrow stem cells can become liver cells

..., the cells might be used to create bio-artificial livers and replace the use of pig liver cells, which are a commonly used source of cells now. Much as dialysis machines can be a bridge for patients waiting for kidneys, a bio-artificial liver can help bridge a person from acute liver failure to transplant....

Monkeys that drink heavily develop signs of liver disease, Wake Forest study shows

...ts in the light drinkers. Second, biopsies of the livers of the heavily drinking monkeys found evidence of "fatty liver." He said, "That is very characteristic of what one sees in alcoholics." This is still a reversible stage of alcoholic liver disease. He said he has seen no evidence so far of cirrhos...

Researchers discover molecular 'switch' that tells body to store or burn fat

...lack of SCD-1 in the mutant mice also caused their livers to be normal and not fatty. "Inhibiting SCD-1 could be of potential use for reducing weight and for reducing fat content in liver, which is also an important clinical problem," says Friedman. Fatty liver, clinically known as steatosis, often develop...

Research identifies enzyme involved in fat storage

...ain criteria: the extent of gene activation in the livers of ob/ob mice; the extent of the genes' response to leptin treatment; and the difference in gene activity in the two groups of mice. These rankings led to the identification of several dozen major genes, of which SCD-1 was most prominent. "Seeing S...

Ecologist's book on introduced species' destructiveness

...stralian pastures, sickens sheep by damaging their livers with plant toxins. Yet the screw-worm fly is a curse to cattle in tropical regions everywhere in the world -- except Australia. Other invaders sound like they stowed away in shipments of Harry Potter books: Oxford ragwort was deliberately imported fr...

Transplantation Society Congress

...th liver metabolism problems Cells from discarded livers became stem cells that in bioartificial device sta...liver transplants in five years since use of split livers became routine in one Italian hospital Waiting times have been sharply reduced for children needing...

Hibernators may hold the key for better human organ preservation

...ion to preserve their viability. Currently, donor livers only remain viable if their cold storage time does not exceed 24 hours. Cold storage banking of the liver of a torpid hibernating ground squirrel has shown that the viability of the liver is significantly longer before it shows signs of damage whe...

Scientists identify 'genetic signature' of stem cells

... more than 200 cell lines derived from mouse fetal livers and found one that was particularly effective supporting stem cells. In the current paper, Moore's research team, which included scientists from the University of Pennsylvania and France, compared the genes active in the supportive cells to those in ...

Tips from the Journals of the American Society for Microbiology

...tion that IL-18 can inhibit HBV replication in the livers of these transgenic mice, especially in concert wi...n-18 inhibits Hepatitis B Virus replication in the livers of transgenic mice. Journal of Virology, 76: 10702-10707.) ENGINEERED BACTERIA DETECT POLLUTANTS ...

Common Indian spice pigment can prevent onset of alcoholic liver disease, study finds

...d levels of these proinflammatory mediators in the livers of rats fed FE vs. FD diet. Remarkably, treatment with curcumin resulted in a normalization of levels of each of the these proinflammatory mediators. Conclusions Dr. Nanji and his team found that that alcohol-induced liver injury was associated wi...

Could hibernators hold the key to improving organ preservation?

...vious studies from this research team suggest that livers from hibernating ground squirrels show superior to...scientists and their colleagues compared harvested livers from torpid ground squirrels, from rats (which don't hibernate), and from ground squirrels in summer...

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