Bone marrow stem cells may one day help treat damaged livers
...ransplanted with human stem cells. They tested the livers for the presence of human albumin, a protein produ...er of human-albumin-producing cells in the damaged livers of mice that had been treated with human hepatocyte growth factor. In some cases, albumin began show...Mutated protein combination tied to excessive sugar production
...able the switch to turn on genes that initiate the livers sugar-making process. Furthermore, when mutations ... when the switch is stuck in the on position. The livers manufacture of sugar from raw materials, a process called gluconeogenesis, is designed to provide th...Researchers identify clotting protein which causes hepatitis B
...scovered protein which causes blood to clot in the livers of humans with viral hepatitis. In animal trials, this same protein causes blood to clot in the livers of mice that are exposed to the corona virus. Blood or fibrin clots are the clumps that result from ...Immune system drug may increase availability of liver transplants
...le might one day dramatically expand the number of livers useable for human transplantation. Studying rats w...ivers, the researchers discovered that bathing the livers in a human immune system protein called interleukin-6 (IL-6) rescues them from failure when transpla...'Stop leak' solution found for toxicity problems in experimental gene therapy
...ht-fold the concentration of IL-12 in the animals' livers compared to injecting the gene-bearing virus alone, the investigators found. "The alginate solution is simple and straightforward," said Yuan, who added that this algae preparation is a nontoxic biocompatible polysaccharide used in tissue engineering...Genetic basis for gender differences in the liver
... and females resides in the liver. Male and female livers express different subsets of genes, which affect t...n on male-specific liver genes, causing the female livers to adopt characteristically male patterns of gene expression. According to Dr. Christopher Krebs, f...Growth hormone activates gene involved in healing damaged tissue
... inserted the human Foxm1b gene in aged mice whose livers had been partially removed (the two species have v...levels of Foxm1b proteins and induced the animals' livers to grow back at a rate typical of young mice. Further research detailed how the gene directs the bus...Gene mutation leads to super-virulent strain of TB
...than TB." The researchers compared the spleens, livers and lungs of mice at various time points throughout the experiment, from 24 hours to 41 weeks after infection. They found that the progression of the unmodified TB strain hit a plateau about 17 weeks after infection, while the mce1 mutated TB strain ...Microscopes provide new view for tissue engineering
...ducts ranging from skin replacements to substitute livers to inside-the-body treatments of osteoporosis. NIST scientist Joy Dunkers and her colleagues paired an optical coherence microscope---a high-resolution probe of the scaffold interior---with a confocal fluorescence microscope---used to track cells sta...Growing human organs on the farm
... 7 and 15 per cent of all the cells in the sheep's livers are human. The human cells must be injected around halfway through gestation- before the fetus's immune system has learned the difference between its own and foreign cells, so that the animal does not reject them, but after the body plan has formed...U. of Colorado professor pioneering tissue engineering from knees to hearts to brains
...ring field is to regenerate organs such as hearts, livers or kidneys. There are more than 40,000 people in need of heart transplants in the United States annually, but only 2,000 to 3,000 donor hearts are available annually for such transplants. "To achieve the engineering of complex organs, we need advanc...Ribozyme package effective against hepatitis B virus
...troys up to 80 percent of hepatitis B virus in the livers of mice. "This marks one of the few successful in vivo, or in-animal, models of an effective therapy to reduce the production of hepatitis B virus," said Gary Clawson, M.D., Ph.D., professor of pathology, biochemistry and molecular biology, Penn Sta...Study may improve survival of transplanted livers
...ffectively in the recipient. However, transplanted livers typically incur substantial damage when blood flow is restored to the organ after the transplant. This damage occurs when ischemic, or oxygen-deprived, tissue is re-introduced, or reperfused, to adequate blood flow. The study, to be published in the...Genetic modification in mice lowers cholesterol and homocysteine by half
...archers genetically altered the mice so that their livers lacked either the CT or the PEMT pathway, the mice appeared normal and bred normally. But in each case, whether the CT or the PEMT pathway was missing, levels of lipoproteins were decreased by as much as half. This suggests, said Dr. Vance, that...Genetic discovery could dramatically reduce need for liver transplants in children
...ed in The Lancet, Dr. Bezerra obtained biopsies of livers of 14 infants with biliary atresia. Using gene chi...nflammatory signal that is highly expressed in the livers of children with biliary atresia, "obstruction of bile ducts in mice was completely prevented, jaund...Patented process preserves transplant tissues/organs
...rtilage and skineven whole organs such as kidneys, livers and heartscould become more widely available for transplants as a result of a patent issued recently to Organ Recovery Systems of Chicago for a method to chill body tissues and organs well below freezing without forming ice crystals. The new process ...Peering inside the body, with a new spinliterally
... rabbit flesh. He also has taken disembodied mouse livers and brains for slow spins around the magnet, revealing chemical spectra in tissue up to 10 times the resolution seen in stationary NMR. But it's living tissue that holds the most promise for this method, Wind said, because there is no good way to se...9/11 search-and-rescue dogs exhibit few effects from exposure to disaster sites
...e phosphatase activity, which indicates that their livers were actively filtering toxins from their bloodstream. The serum globulins were also higher in the first year in deployed dogs, suggesting activation of the immune system. As the study progressed, however, these numbers came down to close to those ...