Study of flu patients reveals virus outsmarting key drug
... proteins on the surface of the virus, effectively locking them in their host cells and preventing the virus from escaping and infecting new cells and hosts. In a pandemic caused by a new strain of flu virus, new vaccines would need to be developed to cope with changes the virus creates to escape immune dete...Separation day arrives for Mars Express and Beagle 2
...a pyrotechnic protractor that releases a ball cage locking device. This allows a spring within the SUEM to push the probe from Mars Express. A helical guide groove induces a linear velocity of 0.3 m/s (1 ft/s) and an angular velocity of 14 rpm into the probe....Study offers new insight into Rett Syndrome
...mulus disappears, MeCP2 re-attaches to BDNF, again locking the deadbolt until a neuronal stimulus starts the process again. Greenberg and Jaenisch say they have never before witnessed this kind of process. "I find this to be an extremely exciting new development," says Adrian Bird, professor of genetics at ...RSRF-funded study leads to breakthrough for Rett Syndrome research
...mulus disappears, MeCP2 re-attaches to BDNF, again locking the deadbolt until neuronal stimuli start the process again. Greenberg and Jaenisch say they have never before witnessed this kind of process. "I find this to be an extremely exciting new development. It is particularly gratifying that RSRF support ...Silent DNA architecture helps block cancer cell growth
...oratory on Long Island have recently shown that by locking cancer cells into a permanent state in which they remain alive but can no longer proliferate, cellular senescence contributes to successful outcomes following cancer therapy. Now, the same group has uncovered a precise molecular mechanism that helps ...Rockefeller scientists identify 'natural' proteins that push stem cells to produce hair, not skin
...ll to change shape, so that they can zip up tight, locking together through all the many E-cadherin proteins found on the outside of the cell, he says. Any extra beta-catenin produced within these cells that is not used to link E-cadherin to the actin cytoskeleton is quickly gobbled up by special enzyme "mac...Bacteria can't do their thing if they don't have cling
... of the "bun" snaps shut around the strand, firmly locking the two subunits together. In this way, the fiber grows longer one "snap bead" at a time. Discovering that the fibers consist of interlocking tails explains why bacterial pili are so durable and able to resist harsh conditions in the laboratory, says...Researchers find synthetic molecules that may literally be the key to 'locking away' unwanted DNA
...teracting with particular sections of DNA code. By locking up the DNA in this way scientists could stop particular sequences of DNA from activating biological changes that doctors or scientists would rather avoid, or wish to regulate closely. Until now researchers trying to devise synthetic molecules that wo...February media highlights - GSA Bulletin
...en detected during the last 15 years, might signal locking of the Elat fault zone. This may result from episodic global reorganization of the systems mode of strain energy release, reflected in the configurational entropy of stress states on the fault. These results have significant implications for seismic ...LabNotes -- research highlights from Pacific Northwest National Laboratory
... worker leaves a room without properly closing and locking a safe, file drawer or other security container. M...al sensors track the position of a safe's door and locking mechanism. This information is relayed to an optical sensor mounted at the room's exit point, which ...Gene barrier in corn may boost trade, environment
... into modern hybrid corn, is capable of completely locking out foreign genes, including those from genetically modified corn. The discovery is important because it means farmers will have access to a technology that can ensure the genetic integrity of their corn crop, making it easier to export to countries ...U-M scientist finds molecule plants use to control early cell development
...s in the cell nucleus telling them to turn off the locking signal that keeps meristem cells from developing. Once the locking signal stops, the meristem begins forming a tiny plant shoot, which will grow into a stem and, event...Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
...e able to blockthe creation of a virus "envelope," locking the virus within the infected cell.The virus, then, is rendered "dead," or non-infectious. Acccording to Dr. Block, worldwide, HCV chronically infects some 100million people, with as many as four million chronic carriers in the UnitedStates. ...... That's important because not only is the molecule locking onto its intendedtarget, it's also getting past the blood-brain barrier. This barrier blocks theaction of many drugs on brain cells, making diseases that affect the brain oftenso difficult to treat. To prove further that the PNA had reached the brain...Under the hood of a cellular transport machine
...ocess isreminiscent of images of alien space ships locking into the mother vessel (seevideo). The new insights come from combining an overall view of a barrel-shaped clathrinlattice, obtained using cryo-electron microscopy by Barbara Pearse andcolleagues at the MRC Laboratory for Molecular Biology in England......by NASAand its partners. They deliberately avoided locking the experiments in placebecause science usually moves at an unpredictable rate, and today's discoveriescan redirect tomorrow's plans. Watch this space. We'll have more on spacestation science activities as they develop....Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
... out above themolecule's surface hide the critical locking regions. When the virus reachesits target, the loops collapse and move out of the way, unmasking the lockingregions. An icing of carbohydrate molecules that also shields the receptor-bindingregions of the gp120 surface from antibody attacks. ...FDA Approves Hopkins-Designed Implants To Restore Lost Voices
...the sizer and replace it with a same-size implant, locking itin place with a small shim of the same material. "There's no greater thrill for both the patient and the doctor than tohear the patient speak again in his or her natural voice," Cummings says. "Patients can talk immediately following the s......es most peptic ulcers clingsto the stomach wall by locking onto specific receptors on cells in the gastriclining. Collaborators in Sweden and the United States now have identified andisolated a bacterial protein that allows the microbe to cling. "With this attachment protein in hand, it eventually sh...