Discovery Of A Molecule That Controls Bile Acids May Lead To New Cholesterol Drugs
... Orphan receptors are molecules believed to be the locks that controlbiochemical processes but whose function and ligand, or key, to activate thecellular changes, is unknown. FXR acts as the lock that binds with bile acids.When this happens, the receptor represses the gene to regulate the enzymecholesterol...Synthetic Lock Binds Some Molecules, Excludes Others
...ilityto distinguish one moleculefrom another. Like locks accepting keys, proteins function by being able to... other shapes from entering. The idea of molecular locks and keys goes back a hundred years, but it is onlynow that chemists have madeprogress in making arti...Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
...tructure can tell us a lot more about how thevirus locks on to immune system cells," says Anthony S. Fauci, M.D., director ofthe National Institute of Allergy and Infectious Diseases (NIAID). "We now havespecific target sites on which to focus in developing new drugs and vaccines." The research, funded in...Hormones Found In The Brain May Determine How Much You Eat And Affect Obesity And Diabetes
... appetite. After determining that they had the locks (receptors) and keys(ligands) that fit together to begin the intercellular communicationprocess, the investigators tested it on rats. They used catheters toadminister some of the neuropeptides to the animals' brains and foundthat the proteins stimula...Wake Forest University Study Takes Students In Flight With The Albatross
...atellite notes the strength of the signal and then locks in the latitude and longitude, time and other data and transmits it to receiving stations in Fairbanks, Alaska; Lannion, France; or Wallops Island off the coast of Virginia. At 1 a.m. Eastern Standard Time each morning, a processing station in Tollo...