Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
... drug binds to this part of DHPS, the enzyme would lose the ability to bind to DHPP and help the cell make folate," White said, "and if the enzyme mutated enough to avoid the antibiotic, the change in shape of this critical part of DHPS would destroy its ability to bind DHPP anyway. Either way, our new mo...University of Alberta researcher looks for clues to mysterious disease
... range). Soon after the onset of A-T, children lose their ability to write and speech becomes slow and slurred. Reading eventually becomes impossible because eye movements are too hard to control. Other features of the debilitating disease include mild diabetes, premature graying of the hair, difficul...'Fossil genes' reveal how life sheds form and function
...in-Madison. "The other side of the coin is that we lose things. Losses as well as gains make up the story of evolution." Writing Sept. 20, in the Proceedings of the National Academy of Sciences , Carroll and colleagues Chris Todd Hittinger and Antonis Rokas describe the discovery of a set of seven genes ...Prion propagation: Avoiding the toxic oligomer
...ate in tissue. When amyloid precursors and prions lose their normal conformation, they acquire the ability to infect their neighbors. Like molecular dominoes, the fall of one malformed protein precipitates the downfall of its neighbors, as one protein after another assumes the misshapen form of the first...Endangered species list more bleak than originally thought
...t was dependent on the vine for survival. "When we lose this vine, this beautiful butterfly dies off with it, and we'll never see it again except in photographs at museums," said Proctor. "And when that happens, it can never be recovered." While this new research has implications for theoreticians who cal...NJIT professor receives Presidential Award for breakthrough research with adult stem cells
...ne, Arinzeh says. In many such surgeries, patients lose their limbs. But if her method of implanting stem cells mixed with biomaterials is shown to induce bone repair, amputation may not be necessary. Stem cells could also help patients suffering from osteoporosis, whose fractured bones can be regenerated...New research shows air pollution can reduce children's lung function
... lung capacity gradually declines. Adults begin to lose lung function by 1 percent each year after age 20. "Lung development in teenagers determines their breathing capacity and health for the rest of their lives," said John Peters, M.D., Hastings Professor of Preventive Medicine at the Keck School of Med...Sandia experiments may reduce possibility of future water wars
... Conventional farming methods in arid regions lose huge amounts of water through evaporation and over-absorption by soil. Over time, this can also result in soil salination and loss of agricultural productivity. Neither are factors in hydroponic greenhouses, which do not require high-quality arable l...Molecular staples shape a cancer killer
...hers to overcome the tendency of short peptides to lose their critical three-dimensional structure and their ability to kill cells -- when removed from the context of the complete protein. This has been one of the greatest obstacles associated with using short peptides as therapeutic agents, and has hind...Study reveals first genetic step necessary for prostate cancer growth
...r Research, found that when mice are engineered to lose a single copy of a gene called Rb in their prostat... Cells with defective or missing tumor suppressors lose their brakes on cell division, a hallmark of cancer. The researchers developed a system using mice t...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...mor immune response, because these dendritic cells lose their ability to induce tumor rejection, which in turn may explain why some tumors are tolerated immunologically. "We are the first to show that dendritic cell precursors in tumors build blood vessels," says Coukos. "This has previously been seen in ...Bright idea could doom cancer and viruses, say Purdue scientists
... process. "That's the reason cancer patients often lose their hair," Morrison said. "Hair cells, like many others in the patient's body, are also destroyed by these platinum-based chemotherapy drugs. So for a long time, physicians have sought other substances they have more control over. If we had a drug ...Newcastle scientists get UK's first stem cell license
...al backing or, as has happened before, the UK will lose out." Current funders of the research team include the regional development agency One NorthEast, Newcastle University and Newcastle's Center for Life, which was established in 2000 by the Millennium Commissionto foster advances in the life scien...The telomere crisis: A crucial stage in breast cancer
...rplasia." "The chromosomes in these growing cells lose a hundred or so base pairs of DNA every time they divide," Gray explains, "because the usual DNA replication processes don't copy DNA all the way out to the ends of the chromosomes. This erodes the DNA sequences that interact with proteins to form st...Commercialization deal boosts hope for new sickle-cell drug
...kle-shaped structures, and also causes the cell to lose water. This dehydration, in turn, hardens the cells and promotes sickling by hastening polymerization. "When you dehydrate, you increase by orders of magnitude the tendency to sickle," says Dr. Brugnara. "It's a vicious cycle that gets worse......SH, you'd force the body to burn more calories and lose weight," Nillni said. "That would help so many people." According to the federal Centers for Disease Control and Prevention, 61 percent of adults are overweight or obese and 13 percent of children and adolescents are seriously overweight. This epidem...Fluid derived from aloe plant prolongs life after hemorrhagic shock in animal study
... red blood cells. Soldiers wounded in combat often lose significant amounts of blood, and there is no practical way to replace the necessary amount of blood fast enough on the front lines. When this happens, there is inadequate perfusion of the organs which quickly leads to a cascade of life-threatening e...What are babies thinking before they start talking?
... and vice versa. Infants hear these subtleties but lose this awareness as their language skills develop over the first year of life. "The languages of the world vary both in the sounds they require speakers to distinguish and in the meanings they require speakers to convey, and these differences influence...Drug prevents chemotherapy-induced hearing loss, study finds
...they haven't developed language skills before they lose hearing and, as a result, don't know what to liste...weight loss, seven days after treatment. "They all lose weight, but it's significantly less" following NAC treatment, Dickey said. Researchers will continue......nigra, a part of the midbrain where dopamine cells lose function, leading to Parkinson's disease, and the ventral tegmental area, a region containing dopamine cells involved in the rewarding properties of many abused drugs, such as cocaine, amphetamine, opioids and nicotine. Researchers believe pinpointin...