Science: nanoscale 'Trojan Horse' attacks cancer cells from within
...nd to treat solid prostate and widely disseminated lymphoma tumors in mice, significantly prolonging their sur..., larger dose injected into mice with prostate and lymphoma tumors caused tumors to shrink and prolonged the mice's survival by several months in some cases. Al......high expression of Myc in lymphoid B cells induces lymphoma development and leukemia. The tumors that develop ...lleagues have found that if the Myc-induced murine lymphoma has even one defective copy of the Dmp1 gene, this genetic mutation is powerful enough to drive tumo...Scientists identify cells necessary for tumor angiogenesis
... weeks later, these mice were injected with either lymphoma cells or Lewis Lung Carcinoma cells (lung cancer cell lines). The transplanted mice developed widespread metastasis and died within 26 days, paralleling the tumor growth observed in wild-type animals. Importantly, the blue bone marrow derived cells ...ChemGenex uses genomics approach to develop new anticancer drug, predict possible side effects
... suggests other therapeutic uses for Ceflatonin in lymphoma and as a chemopotentiator in solid tumors. The research reported by ChemGenex today demonstrates that Ceflatonin affects specific genes and cellular pathways both in vitro and in vivo, including genes known to play a role in leukemia and key cellula...UK researchers raise hopes of preserving fertility for women with cancer
...introducing cancer may be over-stated (at least in lymphoma patients) and that preserving ovarian tissue for later autotransplanation might be the viable option for young cancer patients anxious to preserve their fertility. The researchers grafted frozen and thawed ovarian tissue from 18 women with non-Hodgki......y the proteins: a melanoma (skin cancer), a T cell lymphoma and a thymoma (cancer of the thymus). He then injected them into laboratory mice at levels that would typically kill them. All mice injected with transformed cells survived, while none of those injected with untransformed tumor cells survived. They w......provide insight into the cause of certain types of lymphoma and possibly other cancers, according to an articl...nt potential causes of the disease. In one type of lymphoma developed by AIDS patients, called primary effusion lymphoma (PEL), Teitell and his team observed th...New software streamlines the search for disease-causing genes
...oduce 10 different traits and diseases - including lymphoma and asthma. Previous laboratory studies already ha...h gene location, which may open up a new avenue of lymphoma research, according to Usuka. Digital Disease also predicted the four chromosomal regions known to c...Gene chips accurately diagnose four complex childhood cancers
...ncer: neuroblastoma, rhabdomyosarcoma, non-Hodgkin lymphoma (Burkitt's lymphoma) and Ewing's sarcoma. As a gr...y, up to 90 percent of the children with Burkitt's lymphoma recover; about half will survive Ewing's sarcoma and rhabdomyosarcoma, and up to 40 percent will rec...Epstein-Barr virus linked to invasive breast cancer and lymphoma
...ted cancerous lymphocytes in the breast cancer and lymphoma cell lines analyzed in the study. U-M researchers discovered that the EBNA-3C protein binds to a human metastatic suppressor protein called Nm23-H1, which is found in all human cells. "The interaction between the two proteins disables Nm23-H1's na...Scientists identify gene for the leading form of dwarfism
... infections; and a predisposition to lymphoma and certain other cancers. "Our finding is an important first step in understanding how this disease arises," said Albert de la Chapelle, senior author of the paper and ...Crystal structure of protein interaction could lead to new drugs against cancer
...r-expressed, it causes invasion and spreading of a lymphoma that is not normally invasive. "Our work basically provides the details for understanding how these G proteins are activated," he said. "In terms of its clinical implications, Tiam1 is known for its ability to induce normally non-invasive T-lymphom...Fact sheet: the Report on Carcinogens - 9th edition
...s of increased risk for leukemia and non-Hodgkin's lymphoma in workers exposed to ethylene oxide. This information coupled with data on its genotoxic and biochemical interactions with human DNA led to the upgrading to a "known human carcinogen." Tamoxifen - Tamoxifen is listed in the 9th Report as a "know...Wistar scientist receives award from National Cancer Institute
...g research on CTCL, the most common primary T-cell lymphoma of the skin. Using state-of-the-art robotic systems, she and her research team hope to give clinicians and pathologists new molecular tools that will enable them to identify CTCL accurately in its early stage and define the molecular events that con...U-M scientist discover how viruses hide inside human cells
...ng station linking viral DNA to the chromosomes of lymphoma cells. The U-M study is the first to identify a s... will get us in the front door." Using cultures of lymphoma cells infected with KSHV, Cotter and Robertson identified a protein called the latency-associated nu...UI researchers advance potential, potent way to stimulate human immune system
...nical trials are planned for treating patientswith lymphoma at the UI beginning within a few months. Dendritic cells, a type of white blood cell, link the primitive arms of theimmune system with the more sophisticated acquired immune system by producingchemical signals that activate other immune cells and "te...UCSF Study Finds No Association Between Hair Dye And Non-Hodgkin Lymphoma
...e of hair color products and risk fornon-Hodgkin's lymphoma (NHL), the fifth most common cancer in the United ...dye use is an unlikely risk factorfor non-Hodgkins lymphoma and this should prompt researchers to focus on otheretiological clues associated with lymphoma such ...Antisense Therapy Prevents Burkitt's Lymphoma In Mice
...nse therapy to prevent the development ofBurkitt's lymphoma in laboratory mice, showing that this protection i... the limitations of effectively treating Burkitt's lymphoma withchemotherapy is that the drugs eventually wear off, says Dr. Wickstrom,professor of microbiology...NIAID Doctor Successfully Treats Longest Case Of Malaria Infection On Record
...ime, she was mistakenly diagnosed with lymphoma and treated with an oral anti-cancer drug, methotrexate, for 10 days. In response to the chemotherapy, symptoms of malaria appeared but were not recognized as such. After seven days, she developed a recurring high fever and...... the United States arediagnosed with non-Hodgkin's lymphoma each year. Mutations in a gene calledBCL-6 make up the most frequent genetic alteration in non-Hodgkin's lymphoma.Alterations in BCL-6 -- which belongs to the same family of genes as PLZF -- turnon this transcription repressor, leading to lymphoma. "...