Molecular staples shape a cancer killer
...istant cell," said Walensky. "For example, certain lymphomas are specifically driven by BCL-2 overexpression. So, if you could knock down some of the impact of that BCL-2, you would tip that lymphoma cell over the edge toward death." Korsmeyer, Walensky, and their colleagues are now developing and testing dif......f a protein called Mus81 led to the development of lymphomas and other tumours in mice. The research is published in the June 18 edition of Science. "When it was discovered in 2000, a lot of people speculated that Mus81 was the missing mammalian enzyme essential for the processing of the Holliday Junction, a D...Other highlights in the May 5 JNCI
...ancer. The number of actual cases of non-Hodgkin's lymphomas and skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma, among people receiving glucocorticoid prescriptions were compared with the expected number. There were more cases of all these cancers than expected, particularl...Chlamydiae infection may be associated with ocular adnexal lymphoma
...iated lymphoid tissue (MALT) lymphomas, a group of lymphomas that includes ocular adnexal lymphoma. She points out that MALT lymphomas are the result of immune responses gone awry and notes that the results of Dr. Ferreri and his colle...Combination therapy drives cancer into remission
...y well, when combined, for treating "Akt-positive" lymphomas (Lymphomas in which the hyperactivity of a protein...as, and when compared to mice bearing Akt-positive lymphomas that were either untreated or treated with rapamycin or doxorubicin alone. (A copy of the study and ...Pioneer in the genetics of programmed cell death honored
...on the development of individualized treatments of lymphomas and other cancers," she said, adding, "Dr. Korsmeyer's research has had a widespread impact not only on the genesis and treatment of cancer, but also more broadly on biology and medicine. Indeed, his insights have altered our fundamental concept...Natural killer cellers are made, not born
..." Leading oncologists treating human leukemias and lymphomas already track natural killer cell activities after bone marrow and stem cell transplants. James Young, M.D., a researcher at Rockefeller's neighboring Memorial Sloan-Kettering Cancer Center's Allogenic Bone Marrow and Stem Cell Transplant Service, is...Researchers identify new cause of genomic instability
...man genome. When H2AX ceases to function properly, lymphomas and solid tumors can arise because errors in the g... died, he said. The resulting tumors included both lymphomas arising from aberrant immune cells -- which would be common in the loss of NHEJ DNA repair function ...Gene loss creates age- and gender-dependent cancer syndrome in mice
... on the mouse's sex. Female mice tended to develop lymphomas and sarcomas, while male mice developed more epithelial cancers. Chen also found that each cancer lacked any sign of Hic1 expression. Furthermore, loss of the existing copy's function was due solely to hypermethylation of one of the gene's two "prom...Artemis: a little bit is not enough
...rm of immunodeficiency and appear prone to develop lymphomas - malignant disease that originates in B or T cells. These findings suggest that mutations in Artemis or other DNA repair genes could be responsible for other cases of immune deficiency and/or lymphoma. In an accompanying Commentary, Vicky Brandt an...Using RNA interference to tune gene activity in stem cells
...ogene in B-cells causes the mice to develop B-cell lymphomas by 4 to 6 months of age. The scientists, led by Gr... knew that completely deleting the p53 gene causes lymphomas to develop much sooner, and in a more aggressive, highly-invasive form, than lymphomas that develop ...Effects of rare, devastating disease linked to shrinking of cells' telomeres
...ever, resulted in a "near complete suppression" of lymphomas that are common in mice and AT patients. With AT patients, the would-be cancer cells maintain the capacity to activate telomerase, enabling genetically unstable lymphoid cells to become cancers. In the genetically altered mice, the researchers knoc...Scientists find fully differentiated blood cells remain able to switch identity
... drugs, we may be able to convert malignant B-cell lymphomas into much less harmful histiocytomas, tumors composed of relatively inactive macrophages." Previous research has demonstrated that when B-cells are transplanted from an animal into a petri dish, the cells sometimes change into macrophages. Thomas-Ti...Model for common type of cancer developed by UCLA scientists
...at cause these types of cancer. Mature B-cell type lymphomas account for about 85 percent of all lymphomas. The...entical animal develops a different type?" B-cell lymphomas include both Hodgkin's and non-Hodgkin's lymphomas. Specifically, the three types of B-cell lymphoma...Investigators use guilt-by-association strategy to track potential cancer causing genes
...ed p27, which is found in abnormally low levels in lymphomas and breast and other cancers. The team identified... known as the Moloney Leukemia Virus, which causes lymphomas in mice. Upon infection, the virus inserts its own DNA randomly into the DNA of the cell. As a resul...Gene profiles predict survival
...is week. In a large group of diffuse large-B-cell lymphomas (DLBCL), DNA microarrays identified three patterns of gene expression that were correlated with the likelihood of survival after chemotherapy. Individual genes within these patterns formed molecular signatures that had an even stronger correlation wi...Complex gene-swapping spawns a form of lymphoma
...h, and Brigham and Women's Hospital. Leukemias and lymphomas can arise when chromosomes inappropriately swap ge... cell lymphomas, from which they died." Pro-B cell lymphomas are tumors that arise when cells of the immune system, called B cells, proliferate at an immature st...UM Cancer researchers test custom-made vaccine for non-Hodgkin's lymphoma
...ew cases diagnosed each year. Low-grade follicular lymphomas are generally treated with radiation if they are localized or chemotherapy if they are widespread, Dr. Rapoport says. The cancer responds well to treatment, but is likely to recur. I believe this technology offers the potential for better ...UT Southwestern researchers link human lymphomas to polio vaccine tainted with monkey virus
...have established a link between human non-Hodgkins lymphomas and a monkey virus carried by some people, possibl...Barr virus (EBV) sequences have been found in some lymphomas of Hodgkin and non-Hodgkin types. But it looked like a strong viral association did not exist. Thi......Lancet, analyzed samples from 154 patients who had lymphomas and found 42 percent positive for SV40 DNA, whereas many control samples were negative. Dr. Adi Gazdar, a colleague at the University of Texas Southwestern Medical School in Dallas, performed a similar study that confirmed the presence of SV40 in s...