Hammering cancer cell survivin
...nt negative transgenes helps eliminate established lymphomas and prevent the emergence of new tumors in a mouse model. Ribozymes to survivin might therefore be used in a similar manner, probably in conjunction with chemotherapeutic or immunotherapeutic agents, to control human tumors in a clinical setting.......er adapted to reproduce. However, about 25% of the lymphomas in these Myc transgenic mice do not display alterations in p53 or its interacting proteins. Dr. Sherr and colleagues have discovered why. Dr. Sherr and colleagues have found that if the Myc-induced murine lymphoma has even one defective copy of the D...UK researchers raise hopes of preserving fertility for women with cancer
...based on worst-case scenarios of highly aggressive lymphomas that were likely to have already spread at the tim... findings are of immediate relevance to women with lymphomas who are considering banking ovarian tissue for fertility conservation and also to their physicians w......modification goes beyond the specific AIDS-related lymphomas found in this research. This could be a general phenomena found in more than one form of cancer, Teitell said. It may be that this modification is a piece of the mechanism that causes a cell to become cancerous. One thing that is not yet known is wha...Human Genome Sciences announces the discovery of a novel immune stimulant
...s may also lead to newtreatments for leukemias and lymphomas that arise from abnormal proliferation ofB cells. BLyS interacts with a specific structure on the surface of B cellscalled a receptor. Drugs that interfere with binding of BLyS to this receptormay kill or at least slow the growth of B cell tumors. ...15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
...nosuppressive drug. THIOTEPA, a drug used to treat lymphomas and tumors of the breast andovary. It has also been used at high doses in combination chemotherapywith cyclophosphamide in patients with refractory malignancies treatedwith autologous bone transplantation. Newly listed as Reasonably Anticipated to ...ORNL Mice Helping Researchers Isolate, Identify Causes Of Cancer
... useful for ourstudies because mouse leukemias and lymphomas are very similar to humanleukemias," said Monica J...her in ORNL's BiologyDivision. "In addition, mouse lymphomas have genetic characteristics thatallow us to isolate the genes involved in the development of the ca...