Brain Protein "Rescues" Neurons From Atrophy
...s theorize that defects in the cell's neurotrophin machinery likely play a key role in many neurological disord...ch will aim at understanding in detail the complex machinery by which brain cells produce neurotrophins and translate the chemical signals they represent into st...Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
...d NO is fantastically symbiotic in carryingout the machinery of life," he said. "Hemoglobin uses a spritzof the NO it carries to help get oxygen into tissues. And NO helps hemoglobincarry away the trash of carbon dioxide. It's fantastic." The work was funded by the National Institutes of Health and th...New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...nt toward new ways to interfere with the malignant machinery of cancer cells to kill them. In a second paper in the October issue of Molecular and Cellular Biology, the scientists reported new understanding of how cancer cells acquire the ability to avoid the natural death, called "apoptosis," that normal cell......at suicideis the cell's default setting. The death machinery is always in place, ready tobe activated. There are many evolutionary advantages to this set-up, Raff saysin The Sciences. "Such a mechanism could ensure that any cell that ends upin the wrong place is automatically eliminated: isolated from its life...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
...iveway to control the G-protein-activated cellular machinery "Because of the critical role that RGS proteins may play in controllingthe duration of a neurotransmitter or hormone-dependent response, it ispossible that these proteins may be involved in many important aspects ofsignal transduction within normal ...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
... set up the binding site on the enzyme's catalytic machinery for properbinding of the SH3 domain," said Kuriyan. In a companion paper in the same issue of Nature , Kuriyan, Sicheri andMoarefi collaborated with researchers Michelle LaFevre-Bernt, B.S., and W. ToddMiller, Ph.D., from the State Universit...New Study Shows Steps Leading To Colon Cancer
...s who showed us that essentially the same cellular machinery that works in people works in fruit flies," the UNC-CH biologist said. "If we want to learn how our own cells operate, it is a lot easier and faster to do that in fruit flies than in humans or even mice." The research published in Science involved ...Duke researchers find existing drugs can stop fungus that attacks AIDS patients
...because fungi, unlike bacteria, use the same basic machinery as humans tocarry out life processes," Heitman said. "This means there arevery few drug targets for fungi. We believe we have found one such target." In previous research, Heitman showed cyclosporin and FK506, two leadinganti-organ rejection dr...Where Fossils Fear To Tread: Scientists Follow Genes To An Ancient Ancestor
... derived - invented a set of body-building genetic machinery so successful and malleable that it has survived t...t least600 million years ago, and that the genetic machinery is very similar in all animals past and present. What makes animals different, what differentiates a...Study: Hydrogen Bonds Aren't Key To DNA Pairing After All
...s shape but can't form hydrogen bonds, DNA-copying machinery nearly always inserts thymine's normal partner, adenine, opposite the molecular impostor. When critics pointed out that adenine is the base mostcommonly inserted when any template base is damaged or missing, Kool and his partners turned the tabl...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...et genes into cells and direct the body's cellular machinery to producetherapeutic proteins." A bad copy of the hAAT gene is thought to causepulmonary emphysema and liver disease. Introducing a good copy into targetcells may slow or halt the development of these disorders. Genes can be delivered to ...New Molecular Switch Is The Key That Unlocks DNA Repair
... Such genes are part of the intricate molecular machinery that fixes the cell when for some reason, cell ...n signals. This occurs by assembling the repair machinery which then orchestrates the correction of these errors. “Without hMSH2 or hMLH1 the cellu...Cellular 'Short Circuit' Causes Insulin Resistance
...ges from theinsulin receptor to the glucose uptake machinery in cells undergoexcessive phosphorylation (a process in which they acquire phosphorusatoms). Such abnormal phosphorylation generates a "short circuit" thatprevents the insulin receptors from communicating their "messages" tothe cells' interior, makin...'Rolling Circles' Provide New Way to Amplify and Detect DNA
... intoa bacterium so the organism's own replication machinery will copy it. The third widely used option for making short strands ofDNA, computerized chemical synthesis, relies on a machine tosynthesize DNA sequences from free DNA nucleotides. But thereagents and solvents used in the synthesis create to...Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
...n used in evolution into the highly specialized machinery of neurotransmitter release....Researchers From Rockefeller University Develop Novel Method To Fight Cancer
...D., provides an avenue forusing the cell's natural machinery to bypass this requirement, allowing theindividual's own dendritic cell to determine the correct part of the tumorantigen that fits their MHC molecules. In a model system, the researcherscollected human tissue and infected it with influenza. These ce...Gene-Reading Problem Linked To Lou Gehrig's Disease
...s. Something may be wrong in the biochemical machinery the body uses to decodetheEAAT2 gene, Rothstein speculates. It's also possible that there is an acquired or inherited mutation in theintrons of EAAT2that gives the wrong cues during the editing process, Rothstein says. The new finding is a...Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs
...anco said, because of the scantknowledge about the machinery of prostate cancer. "The stages in prostat...y to use thisinformation to broadly map the deadly machinery of prostate cancer. "While we think this switch has tremendous physiological consequenc...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...tion from a cell's genome to the protein synthesis machinery of the cell. Dendritic cells circulate thr...us "transfected" into a host cell uses that cell's machinery to make tumorproteins, which are then chopped up and displayed on the cell surface. Mass qua...... various cell activities. Both turn on the genetic machinery thatproduces bacterial toxins, but only one is responsible for the cell-to-cellcommunication instructing the bacteria to build the biofilm. When the generequired for production of the signal was removed from the bacteria, thecommunity did not differe...