Protein is key to fatal disorder and normal cell function
...lipids is galactosylceramide (GalCer). GalCer is a major constituent of lipid rafts. These lipid platforms are important for the initiation of signaling events in the cell, such as programmed cell death, or apoptosis. The mutant cln3 protein lacks the amino acids that serve as a structural binding site for...Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
...dea that SV40 is a common infection of humans or a major cause of NHL. In the future, it will be of interest to develop additional serological assays for SV40 infection for studies of persons with cancer and the general population," the authors write....URI oceanographers to build laboratory to study subseafloor life
...ory for research and research training. As an NSF major research initiative, the award will be matched by $148,000 from the University of Rhode Island. The URI scientists who will initially use the field laboratory are geological oceanographers Steven D'Hondt, Arthur Spivack, and John King, biological oce......with celiac disease eat foods containing gluten, a major protein in wheat, rye, and barley products, their immune system attacks and damages the lining of the small intestine. Development of this disease has been linked to the transformation of normal immune cells, called cytotoxic T lymphocytes (CTLs), th...Research on carbohydrate metabolism receives historical recognition
...merous scientific journals and databases, convenes major research conferences and provides educational, science policy and career programs in chemistry. Its main offices are in Washington, D.C., and Columbus, Ohio ...Genetic analysis rewrites salamander's evolutionary history
...e said. "Only one of the currently recognized four major groups is supported." The study, published this week in the online edition of the Proceedings of the National Academy of Sciences, was conducted by Wake's graduate student, Rachel Mueller, to understand the evolution of the Plethodontid salamanders, ...IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth
...hn's Disease (CD) and ulcerative colitis (UC), the major constituents of Inflammatory Bowel Diseases (IBD), has never been studied, according to the authors of a paper presented at an IBD translational conference sponsored by the American Physiological Society. The paper is entitled, "Neoangiogenesis: a ...A probable cause for high blood pressure identified - shows links with diabetes
...elevated levels of this ribotide may account for a major fraction of cases of essential hypertension. In addition, imidazole-4-acetic acid-ribotide stimulates another group of imidazol(in)e receptors which regulate insulin release. Among natural substances in the body, this molecule is one of the most pote...Molecule awakens and maintains neural connections
...ghly expressed in the brains of embryonic mice. "A major reason we became interested in this molecule is that when we used antibody markers to look at the distribution of the protein, we saw it primarily in the dendrites, with very little in the axons," said Yuh Nung Jan. "If you look at areas of the hippo...Researchers identify distinctive signature for metastatic prostate cancer
...g pathway to a role in prostate cancer, which is a major form of cancer," commented molecular oncologist Charles Sawyers, an HHMI investigator at the Jonsson Comprehensive Cancer Center at UCLA. "The results are incredibly interesting, because they are among the most promising I've seen to enable distingui...Proteins show promise for mosquito control
...a land of 10,000 lakes," she says, where rice is a major crop and the weather is hot and humid, perfect for mosquito breeding. Worldwide, mosquitoes are notorious for spreading not only malaria, but also dengue fever (so painful it's commonly called "break bone fever"), several forms of encephalitis, yel...Joslin President awarded medal from international diabetes organization
...zheimer's disease. Dr. Kahn's laboratory also has major interest in adipocyte (fat cell) biology, an important area of obesity research. He is also the leader the Diabetes Genome Anatomy Project, a consortium of institutions involved in the use of DNA chips and proteomic techniques to study diabetes. A ...Blue marlin in gulf have high mercury levels, A&M study shows
...il and gas platforms in the Gulf of Mexico are the major source of the mercury problem in the Gulf. To investigate the source question, Rooker, Gil and Cai are examining mercury in pelagic fishes from areas with high concentration of petrochemical industries or production platforms and comparing these with...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
... their own anti-inflammatory chemicals. One of the major such "bugs" is the genus Lactobacillus. The research reported below was carried by James Versalovic and Jeremy Andrew Pena at the Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, and by Arlin B. Rogers, Zhongming Ge and James G. ...PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
...ly combated with conventional drugs, could lead to major epidemics if enlisted by terrorists. NIAID is banking that determining which microbial proteins interact with which human host cells will point drug designers toward quick and effective treatments during an outbreak. To conduct the analysis of these ...New research suggests early diet may play key role in protecting against childhood leukaemia
...mental and lifestyle factors are thought to play a major role in the rising incidence. If this is the case, it should be possible to take preventive measures. But first we need to identify the factors responsible. This is the motivation behind the conference Childhood leukaemia: incidence, causal mechani...Charting the future in prostate cancer care: A call to action
...r experts. A distinguished panel will present the major findings of the Report and its authors' calls to action to address the urgent need to improve the management of prostate cancer and accelerate the development of better treatments and a cure. The PCF will also debut a public service announcement cam...Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
...herlands, and was the invited keynote speaker at a major European Union scientific meeting on soil conservation. In California, Torn has led state-supported studies to assess effects of global warming on wildfire danger, and on threats to wildlife, agriculture, and public health. Says Torn, "We need to un...IBD (Crohn's/ulcerative colitis) conference adds 18 speakers; APS meeting starts Thursday
...robably will be their first oral presentation at a major conference." Broad range of topics reflects comprehensive attack on IBD Three speakers have been added to each of the six symposia on topics ranging from "new therapeutic strategies in the treatment of IBD" to the "role of the immune system in ...Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
...he pathogenesis, diagnosis and treatment of IBD. A major effort has been directed toward identifying and characterizing the adhesion glycoproteins that enable leukocytes to bind to vascular endothelial cells. Drugs that specifically target adhesion molecules involved in leukocyte recruitment are effective ...