Sweet success in targeting sugar molecules to cells in living animals
... spatial and temporal control in live animals is a major step forward for chemistry." Glycosylation is the ... the promise of these studies, researchers faced a major challenge in finding the means to target sugars with specific markers for biological study to the su...When is a mouse like a test tube?
... which cells decorate themselves. Such sugars play major roles in cell-cell interactions, and often provide... spatial and temporal control in live animals is a major step forward for chemistry." She and colleagues are now developing radio-labeled azide compounds tha...Gene linked to cleft lip and palate identified
...esearchers has identified a gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families, it was reported today in The New England Journal of Medicine . "Cleft lip and cleft palate are among the most common birth defects in the United States," says Nancy ...New model can aid in understanding immune system diseases
...velopment of therapeutics. In addition to Bishop, major collaborators on the projects included the two lead authors Laura Stunz, Ph.D., UI associate research scientist, and Lisa Busch, a UI doctoral candidate in molecular biology who has since graduated....New mechanism for display of foreign proteins to immune system
...n to show that the cysteine protease Cat S plays a major role in generating presented proteins for the TAP-independent pathway of crosspresentation and contributes to immunity to viruses and transplanted tissues. "We show unequivocally that this pathway is truly separate from the conventional TAP-dependent...Forgetting, reminding, and remembering: The retrieval of lost spatial memory
...s or a failure to retrieve them -- is not clear. A major challenge in resolving this question experimentally is being able to determine whether an animal has truly recovered a lost memory or has simply re-learned the task at hand. By refining a classic behavioral neuroscience experiment to test spatial lea...Using statistics to decipher secrets of natural mutation
...s has been of great interest because mutations are major drivers of evolution," said Green. "However, it's surprising how little is still known about their causes." Previous studies have revealed a number of biases in the rates of different types of mutational change. These arise in part from the innate b...Rare mutations can significantly increase risk factor for heart disease
...ol, known as high-density lipoprotein (HDL), are a major risk factor for heart disease. Gene mutations pre...bs said, "was how much do single gene defects with major effects contribute to complex traits?" Although mutations with such a strong effect on overall HDL ...Alcohol-use and depression among pregnant and postpartum women
...at greater risk, into the postpartum period." "One major implication of these findings is that women experiencing these co-occurring problems during pregnancy should seek help for both of these problems as soon as possible," said Eiden. "Given the challenges of the postpartum period due to the stresses of...Genes can influence both alcohol consumption and dependence
...rinking, particularly among young people or at any major celebration. From this study we can see more clearly that certain people are born with an increased risk of developing alcohol problems. An individual who is aware of a family history of alcohol-related problems needs to take efforts to reduce thei...'New and better drugs for tuberculosis' goal of UH professor
...l provide a protein science perspective on several major infectious diseases and cutting-edge approaches toward the development of potential treatments....Technology already exists to stabilize global warming
... The finding counters the common argument that a major new technology needs to be developed before greenhouse gasses can be controlled, said professors Stephen Pacala and Robert Socolow, who conducted the study. "It certainly explodes the idea that we need to do research for a long time before get...Emory researchers map structure of anti-cancer molecule
... that is involved in cell division. Tubulin is the major component of microtubules, the hollow cylinders that serve as a skeletal system for cells and a scaffold for chromosomes in the dividing cell. When epothilones or taxanes bind to tubulin, the protein loses its flexibility and the microtubules can no ...Body's own defense against H. pylori, cause of stomach ulcers and stomach cancer
...i, cholesteryl-alpha-D-glucopyranoside, which is a major component of the bacterium's cell wall and essential element to its growth. Further experiments confirmed that the O-glycans capped with alpha 1,4-linked N-acetylglucosamine blocked H. pylori's ability to synthesize the cholesterol. "This...... of the technology, sees the creation of SPIM as a major breakthrough in both the scientific and microscopy communities. "Not only is this microscope simply more powerful than many existing technologies, but it also comes at the perfect time for biologists who need to study complete systems." Ernst Stelzer...Evolution of whale hearing unfolds in fossil record
...equipment of later echolocators), they had taken a major step forward in refining underwater sound reception. In addition to Thewissen and Nummela, the research team includes Sunil Bajpai, Indian Institute of Technology, Roorkee; S. Taseer Hussain, Howard University College of Medicine; and Kishor Kumar, ......'s body time, a lack which has stood as one of the major barriers to realizing the promise of chronotherapy...and of diagnosing circadian disorders represents a major step toward the fulfillment of the longstanding dream of scientists and physicians: to put a readabl...T. rex owes its giant size to the ultimate teenage growth spurt
...rovides the first evidence of its kind pointing to major differences in whole body growth rates among a non-avian group of dinosaurs," said Gregory Erickson, PhD, Assistant Professor of Biological Sciences at Florida State University, a Field Museum Research Associate and lead author of the paper. Other co...APS announces the winners of its 2004 postdoctoral fellowship in physiological genomics
...on (organogenesis). Though the liver is one of the major digestive organs vital to human physiology, the mechanism underlying liver organogenesis is largely unknown. He is now using a forward genetic approach in zebrafish to identify new factors that are key to liver organogenesis. This study will shed n...