Technique plucks rapidly evolving genes from a pathogen's genome
... previously unknown genes in the tuberculosis and malaria parasites that could be potential drug targets. "I...rculosis) and the 5,000 genes in the genome of the malaria parasite (Plasmodium falciparum). The genes in these organisms that turned out to be rapidly evolvin......netically modified mosquitoes that cannot transmit malaria are one hope for battling the disease that still k...ategy. Other scientists have proposed controlling malaria by releasing into the wild mosquitoes genetically engineered to resist malaria. If the resistant mos...Surprises found in gene variation associated with schizophrenia
...cell abnormalities but also provides resistance to malaria and thus promotes human survival. However, two copies of the variant gene cause the debilitating disease sickle cell anemia. ...Purdue scientists finding ways to outsmart crop-damaging bugs
...or mosquito control in Third World countries where malaria is still the No. 1 killer. "In the fly line, we have a known mechanism of resistance, and we understand how DDT works at the molecular level," Pittendrigh said. "So then we can describe and understand molecularly how negative cross-resistance occurs....GenVec, U.S. NMRC, and PATH's Malaria Vaccine Initiative partner to expand malaria vaccine efforts
...unced a dynamic partnership to assess whether five malaria antigens, or proteins, can generate strong immune ...is partnership will advance and expand the ongoing malaria vaccine development program between GenVec and NMRC. Malaria is one of the world's three leading inf...Mosquitoes vs. malaria: How we can win the fight
...r mosquito proteins that affect the ability of the malaria parasite (Plasmodium) to survive and develop in th... 2004), could be used to block the transmission of malaria from mosquitoes to humans. "Many researchers focus on the direct effects of Plasmodium on the human ...Aeras partners with Crucell to develop TB vaccine
...st in the world." Crucell's tuberculosis and malaria vaccine candidates are both based on the Company's PER.C6™ and AdVac™ technologies. "We see this collaboration with Aeras as a strong endorsement of Crucell's vaccine programs" stated Ronald Brus, Chief Executive Officer of Crucell. "Cr......idental introduction of mosquito-transmitted avian malaria and pox to Hawaii last century. Native birds essentially "disappeared" from lowland forests, where climate is favorable for mosquitoes and disease transmission. Now a team of USGS scientists at the Pacific Island Ecosystems Research Center in Hawai...New, non-radioactive screen for antimalarial compounds
...Molecular Probes business enables detection of the malaria parasite in cell culture without the need for radi...f the world's population. The major impediment to malaria control is the cost and distribution of antimalarial drugs. Every year, antimalarial treatments bec...2004 AAAS annual meeting spotlights world health, oceans and family science
...oth parents to the disease. Other diseases such as malaria are taking a disproportionately heavy toll on the developing world. In response, the Gates Foundation in 2003 launched a $200 million medical research initiative. Klausner is expected to unveil the Foundation's next major steps at the AAAS Annual Mee...Pew report finds GM insects may offer benefits, but clear regulatory oversight is lacking
...ses, including fighting insect-borne diseases like malaria and controlling destructive insect agricultural pests, but the federal government lacks a clear regulatory framework for reviewing environmental safety and other issues associated with GM insects, according to Bugs in the System? Issues in the Scienc...New advance to combat antibiotic-resistant pneumonia and malaria
...iochemical studies may hold clues to more powerful malaria and pneumonia treatments that could save more than... why enzymes in organisms that cause pneumonia and malaria are becoming increasingly resistant to antibiotics. This work could provide the answer to testing a...Researchers develop model to help control West Nile outbreak
...l models have been used to manage diseases such as malaria but this is the first one to deal with West Nile....Parasite's enzyme structure helps address a public health issue
...n their other family members, like Plasmodium, the malaria bug. Anderson's team is also working on "structure-based drug design" to carefully design drugs to interact with the specific enzyme to influence how the enzyme will function. "We want to prevent DHFR-TS from doing its job in the parasitic or...Third set of awards are announced under interagency biodiversity program
... discoverypharmacological agents for AIDS, cancer, malaria and tuberculosis from tropical forest plants of Laos and Vietnam. Collaborating institutions include the National Center forNatural Sciences and Technology and Cuc-Phuong National Park in Vietnam, the Research Institute for Medicinal Plants in Laos, ...Placental malaria increases mother-to-child HIV transmission
Placental malaria infection during pregnancy significantly increases...n rates were 40 percent among women with placental malaria compared to 15.4 percent for women without malaria. The researchers believe that interventions to pr...Public Library of Science launches PLoS Biology
... research articles on diverse topics--ranging from malaria genetics to elephant evolution--authored by prominent scientists from around the world. PLoS Biology is an open access publication - all of these articles are freely available via the Internet to anyone, anywhere to read, download, print, distribut...UC Riverside to convene conference on genetically modified organisms, Oct. 14-17, 2003
...odifying mosquitoes to disrupt the transmission of malaria and other mosquito-transmitted diseases. "The conference will be distinctive from others exploring issues associated with biotechnology in that it will integrate leading scholars from a variety of disciplinary perspectives, as opposed to most confer...Monitoring malaria: Genomic activity of the parasite in human blood cells
Every year, malaria kills as many as 2.5 million people. Ninety percen...ly in the amount that is needed. In this respect, malaria resembles a glorified virus. Given the remarkable coupling of the timing of gene activation with g...Study reveals genetic activity of key step in malaria parasite's cycle
...ntire cascade. "If the gene expression program of malaria is merely a simple linear progression of activatio...loped in the DeRisi lab, representing thousands of malaria gene sequences. The researchers tracked the genetic activity of the parasite's three DNA packages t...