MGH researchers first to identify genetic malfunction in type 1 diabetes
...setts General Hospital (MGH) has identified a gene malfunction that appears to be central to the development of t...ivities. Finding ways to correct or circumvent the malfunction identified in this study may lead to ways of preventing or stopping the autoimmune reaction at the h...Alzheimer protein found critical to brain development
...ment. "The study shows that the same proteins that malfunction late in life have a key role in the beginning of life," said study author Dr. Alan Bernstein, director of the Samuel Lunenfeld Research Institute of Toronto's Mount Sinai Hospital and professor of medical genetics at the University of Toronto. Post-d...Cancer gene is normally a 'carpenter' in the cell
DURHAM, N.C. -- A gene whose malfunction causes several leukemiasnormally functions as a "molecular carpenter," Duke pharmacologists havediscovered. The gene, called c-Abl, triggers other molecules that construct theinternal framework of cells. According to the scientists, this dis...'Knockout' mouse may lead to major understanding of human kidney disorder
...le, the group has since determined that thiskidney malfunction closely mimics the human disease, IgA nephropathy. Theresearchers also prevented the disorder in the mice by supplying the deficientanimals with the uteroglobin normally made by the non-functioning gene. "This mouse model matches the human f...W.M. Keck Foundation gives USC $110 million
...to neurological disorders and to obtain data onthe malfunction of the expressed genes that cause disease. Using aninterdisciplinary approach including molecular epidemiology, neurobiology andgenetics, USC scientists will be able to understand how each variablecontributes to disease progression and can help in de...Newly discovered gene family may regulate important biological processes
... regulation of cell divisionin all tissues and may malfunction in cancer cells," Watson said. "The next stepis to discover with which proteins Morc interacts in the nucleus. This will giveus clues as to its biochemical function." The scientists are investigating when Morc is expressed in the mouse embryo.This wi...Master Switch May Help Cancer Cells Hide From Immune System
...man prostate cancers, theresearchers said. The PML malfunction may also contribute to the tumor's ability to spread to other areas of the body (i.e., to metastasize). This research was supported by grants from the National Institutes of Health, Kaplan Comprehensive Cancer Center of New York University Medical Ce...UI Researchers Find Potential Gene Therapy For Cystic Fibrosis
... with the disease is 31 years. CF is caused by the malfunction of an ion channel that regulates secretion ofsalt and water that protect the lungs. A specialized protein, known as the CFtransmembrane conductance regulator (CFTR), makes the channel. The gene thatcodes for the CFTR protein is mutated in people with...NYU researchers: Plants have signaling mechanism similar to one in human brain
...suggested arelationship between glutamate receptor malfunction and dementias includingAlzheimer's disease. By growing Arabidopsis in the presence of a givencandidate drug, researchers could quickly screen for the drug's effect onglutamate receptors....Researchers Link Gene Defects To The Course Of A Deadly Form Of Heart Disease
... a longer"recharge" interval, but the channels may malfunction entirely intimes of stress -- often stopping the heart completely. A scarebehind the wheel, a slamming door, even a game of bowling -- allcan be fatal. "The investigation into Long QT syndrome is one of the NationalInstitutes of Health's highest prio...Scientists Find Gene For Severe Form Of Epilepsy
...his, however, thefundamental defect triggering the malfunction was unknown. "Identifying the LDgene gives us the key to open the 'door' of the cell so we can determine thecause of the seizures," says Scherer. The LD gene produces a signalling protein which is thought to be involved in thebrain's breakdown of car...Hopkins Researchers Discover Key Target In Molecular Pathway That Initiates Colon Cancer
...es," heexplains. When suppressor genes, like APC, malfunction either through heredityor as a result of exposure to carcinogens, cells get signals to continuemultiplying until they are out of control. "Now we know that in colon cancer amutated APC gene signals to c-MYC," Vogelstein says. The new findings about......clock is an underlying cause of jet lag, and clock malfunction has been linked to seasonal affective disorder and various sleep and mental disorders. DMS Researchers, Jay Dunlap, Ph.D., professor of biochemistry, Jennifer Loros, Ph.D., associate professor of biochemistry and postdoctoral fellows Yi Liu and Mar...Blindness Linked To The Cytoskeleton?
...e first example of hereditary blindness where a malfunction of the cytoskeleton forms the basis of premature cell death in the retina. What does these findings mean for the patients and their families? Although these results have no direct impact on treatment of patients (currently there is...A New Molecular Marker For Prostate Cancer
...that degrade the p27 protein, and not because of a malfunction in thep27 gene, as is the case with some other common tumor markers like the p53 tumorsuppressor gene. This points to the importance of looking at protein expression-- and not simply genetic analysis -- when evaluating cancer cells, Cote says.Cote's ...Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
...e into two," White said. Recently, helicase malfunction has been found responsible for a classof genetic d...ase's job is to help replicate the chromosomes,any malfunction would be expected to have severe consequences. "No one knows anything about arresting helicase...Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...me cannot,therefore, do its job, brain tissue will malfunction and may, over years,die. This would result in fata...zymesbecome disabled, increased numbers of neurons malfunction and may die, destroyingbrain tissue. The researchers have found this effect in two neurological dis......ic disorders, allare linked by a common problem: a malfunction in the body's regulation ofdopamine, an essential messenger of the nervous system. Neurotransmitters such as dopamine, serotonin and adrenaline are chemicalmessengers that neurons release to their neighbors to signal them to firenerve impulses or in...