Tag: "malignant" at biology news

Award winning researchers reveal potential new role for Glivec

...r called dermatofibrosarcoma protuberans (DFSP) a malignant tumour that occurs in the second layer of the skin (the dermis)[1]. He said that complete control of the disease was achieved in eight out of 10 patients in a Phase II trial either through imatinib alone or imatinib plus surgery. The research team ar...

$7.5 Million grant to Yale researchers for role of viruses in cancer

...vical cancer cells for the cells to maintain their malignant characteristics, validating the viral genes as new therapeutic targets. In the current granting period, the DiMaio laboratory will continue to dissect the pathways activated when HPV oncogenes are repressed in cervical cancer cells. Epstein-Ba...

Targeted therapy knocks out pediatric brain cancer in mice

...subset of medulloblastoma, the most common type of malignant pediatric brain tumor. The finding is encouraging in that such precise, targeted therapies may someday replace traditional treatments that can have overwhelmingly negative side effects for pediatric cancer patients. The research is published in the S...

New anti-inflammatory strategy for cancer therapy identified by UCSD researchers

...ancer showed that cancer metastasis, the growth of malignant tumors beyond the original site, was halted with inhibition of either one of two naturally occurring substances, a pro-inflammatory protein called nuclear factor-kappa B (NF-kB) or an inflammatory mediator called tumor necrosis factor alpha (TNFα...

IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth

...sis of cancer because it increases blood supply to malignant tissue. Relatively recently, a novel pathogenic role of angiogenesis has been established for such chronic inflammatory diseases as rheumatoid arthritis, psoriasis and atherosclerosis. As a result, suppressing neoangiogenesis is being investigated a...

Analysis of gene expression in lymphoid cells can determine lymphoma cancer

...ression during normal lymphoid differentiation and malignant transformation," appears in the Journal of Pathology (Volume 203, Issue 4). Lymphomas are generally difficult to diagnose since no single test currently exists to sufficiently establish their presence. Clinical practice often revolves around a patho...

Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth

...r chemoprevention, and Jackson exposed cultures of malignant human breast cancer cells to SUL. Within hours, SUL blocked cell division and disrupted microtubules, which are long, slender cylinders made up of tubulin (protein), that are essential for the separation of duplicated chromosomes during cell divisio...

Other highlights in the August 18 JNCI

...giogenic, and metastatic potential of a variety of malignant tumors, and with poor survival of cancer patients. In a new study, Israel Vlodavsky, Ph.D., of the Bruce Rappaport Faculty of Medicine in Haifa, Israel, and colleagues of the Hadassah Medical Center in Jerusalem found that silencing the heparanase ge...

Tips from the journals of the American Society for Microbiology

...ls, proteins E6 and E7 are the determined cause of malignant transformation. In the study mice were immunized with a DNA vaccine encoding CRT (a binding protein with many cellular functions) and linked to E6 targeting HPV-associated lesions. Results showed a significant T-cell immune response specific to E6, ...

Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels

...ricans each year and is considered one of the most malignant and deadliest forms of cancer, generally resulting in death within one to two years following diagnosis. The disease is usually treated with surgery, followed by conventional radiation alone or in combination with chemotherapy. However, the main tum...

UCSD researchers are first to demonstrate molecular link between inflammation and cancer

...ich become genetically transformed to give rise to malignant cells by the carcinogen, results in increased tumor growth and suppression of apoptosis, whose role is to reduce cancer incidence," Karin added. "Our studies show how NF-kB acts very early in the carcinogenesis process, in two different ways." The r...

Malignant cancer cells generate mice through cloning

...genes in these mice were activated, they developed malignant tumors at a much faster rate than the control mice. According to Lynda Chin of Dana-Farber's oncology department, this research opens up the door to developing cancer animal models in which researchers could ask epigenetic questions. "Although studi...

Study yields insights into precancerous condition

...to 50 percent chance that these polyps will become malignant and lead to patients developing cancer," explains senior author Lewis Cantley, PhD, chief of the Division of Signal Transduction at Beth Israel Deaconess Medical Center (BIDMC) and a member of the Department of Systems Biology at Harvard Medical Scho...

Study supports association between HPV infection and head and neck cancer

...t cells may allow us to design strategies to block malignant transformation," they write. "The promising results from a trial of an HPV vaccine to prevent cervical cancer raises hope that such a strategy can also be used to reduce the incidence of HNSCC."...

Croatian skeletons reveal changing status of cancer in Europe across the centuries

... conditions were benign, with little potential for malignant transformation. "The low frequency of neoplasms i...e-at-death of the specimens is 35.6 years. Primary malignant and benign tumours of bone are relatively rare, even in young individuals where the incidence of the...

UCSD team determines cellular stress within body is critical

...tumors is unique because the unregulated growth of malignant cells does not allow for the normal development of blood and lymph vessels within the tumor, which could contribute to osmotic stress. If the growth of cancer cells in the body requires a means to adapt to osmotic stress, this stress response pathwa...

ALL survivors bear genetic damage from life-saving chemotherapy

... a 5-20 times greater risk of developing secondary malignant neoplasm's as well as other complications. Subsequent illnesses may be associated with increased changes in the patient's genes resulting from their treatments during ALL therapy. Finette and his team of scientists examined the frequencies of ...

Kaposi's sarcoma virus 'reprograms' blood vessel cells into lymphatic cells

...switches off' blood vessel genes." The most common malignant tumor seen in patients with AIDS, KS also develops in other patients in whom the immune system is suppressed. Characterized by lesions that may look red or purple on the skin or tissues lining areas like the nose and mouth, KS can seriously affect q...

Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue

...Now the chip allows us to compare normal tissue to malignant tissue. "This kind of approach will give us import... be high. "MiRNAs are a new mechanism involved in malignant transformation," he says. "I think it will be found to be a very generalized mechanism and provide a...

Calcium supplements associated with decreased risk of large bowel polyps

...ional factor (calcium) can alter the occurrence of malignant disease (colorectal cancer). That would be a tremendous advance."...

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