Tag: "malignant" at biology news

U-M scientists find cancer's genetic core: 67 genes universally activated in human cancer

...robes that are used to profile tissue samples from malignant tumors. Scientists wash tissue samples on the micr...al image comparing patterns of genetic activity in malignant and normal tissue. "When we started the ONCOMINE project, our goal was to bring all the publicly ava...

Vitamin D analog found to boost radiation

...on therapy is a common course of treatment after a malignant tumor is surgically removed, there are often cells that are resistant to radiation that may cause a recurrence of cancer in the patients future. When combined with radiation, the vitamin D analog EB 1089 is capable of wiping out radio-resistant cell...

Rb2 gene may play role in determining effectiveness of drug therapies against breat cancer

...t suppress the transformation of normal cells to a malignant cell are inactivated or shut off. In this regard, Dr. Giordano's group has made a very important discovery on how the estrogen receptor alpha gene is shut off in breast cancer cells," says Dr. Richard L. Momparler, professor of pharmacology at the Un...

DNA arrays diagnose, predict survival for Sezary syndrome cancer patients

...ntrols, making it a highly specific marker for the malignant cells. The findings, reported in the June 2 issue of the Journal of Experimental Medicine, confirm the power of DNA arrays, still an emerging technology, to identify genetic markers that will more accurately diagnose and predict the course of differe...

Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality

... to become resistant to cisplatin and resume their malignant growth. From scientists' point of view, this vulnerability is a kind of happy accident: they know cisplatin works, but they don't know at the basic level of genes and proteins why; nor do they know why it eventually loses its potency. To find out...

Study shows molecular analysis of early breast cancer lesions may be key to choosing best treatment

... Intriguingly, distinct signatures were found in malignant cells extracted from tumors of different cancer grades grade being another measurement by which tumors are classified. In other words, while tumors at all three of the traditional pathological stages do not significantly differ in their molecular s...

Imaging technique may help in confirming, monitoring treatment of malignant brain tumors

...) to measure sodium concentrations in the cells of malignant brain tumors. Because growth of such cancers are ... can do it at the same time it identifies possible malignant lesions," says Ronald Ouwerkerk, Ph.D., instructor of radiology at the Johns Hopkins Department of R...

Researchers identify important function of NF2 tumor suppressor

...e also been associated with mesothelioma, a highly malignant type of lung cancer caused by asbestos exposure, and may be associated with other forms of cancer. She believes that future research may show that NF2 mutations induced by environmental or other factors could play a broader role in cancer developmen...

Rutgers researcher discovers melanoma causing gene

...ponsible for melanoma, the most aggressive form of malignant skin cancer. A paper describing the research by C... Early detection is key in treating melanoma, but malignant melanoma does not normally respond well to conventional chemotherapy," said Chen. "We need to find ...

Discovery of how prolactin travels to gene's machinery helps explain its role in breast cancer

...mal breast cells or cancerous growth and spread in malignant ones. But Dr. Clevenger did not believe this was the only way prolactin worked. Using breast cancer cells in a petri dish, he showed that prolactin is able to physically enter the cell, travel straight to the cell's DNA, and directly activate the p...

DNA-based vaccine triples survival for dogs with melanoma

...tem. For nine dogs that naturally developed canine malignant melanoma, treatment with a new DNA-based vaccine m...oor with no evidence of improved survival." Canine malignant melanoma (CMM) is the most common oral cancer in dogs and accounts for one out of twenty cancer diag...

Brain gliomas progress as function of crucial gene is lost

...previous molecular markers have been identified in malignant gliomas, none have exhibited such a strong correla...looked at glioblastomas, which are the most common malignant brain tumors in adults and are the most resistant and deadly of all brain cancers to treat. They fou...

Gene that drives cells to commit suicide also plays key role in development of skeletal muscle

...ed rhabdomyosarcoma. Rhabdomyosarcoma is a highly malignant tumor arising when primitive cells called myoblasts do not fuse and differentiate into muscle, but rather grow uncontrollably. Rhabdomyosarcoma accounts for 5-8 percent of childhood cancers and is usually diagnosed within the first 10 years of life. ...

Preventing cancer: Scientists identify a useful piece of JNK

...ng pathway genes in human tumors may contribute to malignant cancer progression. It is likely that this information will be useful for diagnosis and for the design of appropriate treatment strategies." He points out that attempts to target anti-cancer drugs to inhibit the JNK pathway should be treated with ...

Scientists find 'stem cells' in human breast cancer

...as one in 100 appear to be capable of forming new malignant tumors, according to just-published research by scientists in the University of Michigan Comprehensive Cancer Center. The discovery could help researchers zero in on the most dangerous cancer cells to develop new, more effective treatments. "These t...

New Northwestern center targets brain disorders

.... One is a gene-based therapy for the treatment of malignant brain tumors in both children and adults. "Disco...al surgery at Feinberg. "The current treatment for malignant brain tumors is not very effective. One of the big hurdles in brain cancer research is learning how ...

Neurofibromin: It's so degrading

.... NF1 is also associated with an increased risk of malignant neurological tumor development and childhood learning disabilities. Although the Nf1 gene was identified in 1990, this work by Drs. Jacks, Cichowski and colleagues is the first report of how neurofibromin activity is regulated inside the cell. "NF1 i...

Artemis: a little bit is not enough

...deficiency and appear prone to develop lymphomas - malignant disease that originates in B or T cells. These findings suggest that mutations in Artemis or other DNA repair genes could be responsible for other cases of immune deficiency and/or lymphoma. In an accompanying Commentary, Vicky Brandt and David Roth...

Presence of certain tumor markers for melanoma could signal best results for vaccine

...ht have the best results following vaccination for malignant melanoma. According to a study published in the Ja...ication factors for specific treatment regimens in malignant melanoma is a major focus of our studies in the molecular oncology department at JWCI," added Dr. Ho...

Mutation in DKC1 gene can cause rare aging disease and cancer

... In fact, fifty percent of the Dkc1 mice developed malignant tumors with the most common sites for these cancers being lung and breast, he added, noting that this suggests ribosome malfunction is important in the genesis of cancer and may have clinical implications for the identification of new molecular targe...

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