Tag: "mammalian" at biology news

Duke Researchers Show "Editing" Can Fix Faulty Genes In New Approach To Gene Therapy

...'s ownprocesses to rewrite genetic instructions in mammalian cells," Sullengersaid in an interview. "The results have encouraged us to go forwardin exploring the use of this technology to correct disease-causing geneticdefects." The study was funded by a grant from the National Institutesof Health. Duke resea...

Ten Years of Progress For Superfund Basic Research Program

... developed modelsystems including yeast, bacteria, mammalian cell cultures andtransgenic mice. Dixon's presentation will be one of the featuredtalks during the three-day conference. The complete UC research team includes 12 faculty in thedepartments of molecular genetics and environmental health in theCollege ...

Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos

...role in controlling cell cycle in all human and mammalian cells. When pRb-2/p130 is altered and cannot produce its protein, the cell may not reach its natural stage of programmed cell death. Instead, the cell continues to live and grow out of control - possibly leading to tumor formation and c...

Growth Factor Stimulation Leads To Increase In New Neurons In The Striatum And Cortex Of The Brain

...Tanja Zigova previously demonstrated that theadult mammalian forebrain has a remarkable capacity to produce new...ma adjacent to the SVZ. The finding that a mammalian brain can be stimulated to produce newneuronal cells in these particular parts of the brain raises n...

Biological Clocks No Longer Found Only In The Brain

... in which the clock genes remained in sync. A mammalian variant of the clock gene recently was identified, and another similar gene also has been found throughout the body of mice. According to Kay, the discovery of many non-brain clocks in fruit flies could well be true for humans. "In this case it mig...

Researchers Construct Genetic Map For Dogs

...s of both development and behavior in a variety of mammalian species including human. "The notion of a canine genetic map had been proposed by the genetics community years ago; over the last three years we developed the markers to serve as the cornerstone of the map," said Elaine Ostrander, Ph.D., lead investi...

Widespread Genus Of Monkeys Gives Up Genealogical Secrets To Columbia Researchers

...mate evolution, and to the evolution of many other mammalian species inAsia during this time, according to its co-authors. Data on macaquedistribution at different periods in history will give researchers clues to whatfactors influenced that distribution, and will be of most immediate use inhelping decipher t...

Cellular Engineers Design Custom Cell Surfaces Able To Adhere To Synthetic Materials

...ogicalconditions, such as a watery environment and mammalian body temperature. They chose the ketone group. Rarely found on cell surfaces, ketonesreact strongly with a functional group called the hydrazide; the specialreactivity of the ketone could allow a selective affinity for materials that hadbeen...

Plasminogen-related Growth Factors

.../SF and its receptor,the c-Met tyrosine kinase, in mammalian development Discussion E. J. Leonard Biological aspects of macrophage-stimulating protein (MSP) andits receptor Discussion K. Matsumoto and T. Nakamura HGF: its organotrophic role and therapeuticpotential Discussion E. M. Rosen, K. Lamszus, J....

Transgenic Mice Created By Researchers May Shed Light On Human Heart Disease

...oted the new tools and techniques now available in mammalian biology playa major role in the application of basic knowledge to human welfare. Leinwand and her collaborators, who have patented their mutantmyosin transgenic mice through the University Technology Corp., recentlyco-founded a university spi...

Scientists Identify Protein Essential For Iron Absorption, Boost Understanding Of Iron-Deficiency Anemia

...for normal intestinaliron absorption and the first mammalian iron transporter to be characterized atthe molecular level, it appears to be involved in not just one, but several,critical roles in iron metabolism. The results will be published in the Feb. 3 issue (Vol. 95, Issue 3) ofthe Proceedings of t...

Females' Siren Song Initiates Courtship Duets In African Frogs, Columbia Biologists Find

..."Theeffect resembles the action of estrogen in the mammalian central nervoussystem," Professor Kelley said. "That's a topic of considerable interest toscientists examining hormone effects on brain function, since estrogen hasalready been shown to delay the onset of Alzheimer's disease and improve verbalmemory...

PEBBLEs Help U-M Scientists Open A Window On Cell Chemistry

...plied Physics . They were designed to work inside mammalian cells where they can detect subtle changes in concentrations of ions and small molecules. "PEBBLEs are self-contained sensors powerful enough to detect even slight changes in cell biochemistry, but small enough to avoid damaging the cell," said ...

USC Study On Soy's Anti-Cancer Effects

...ime, how genistein is able to directlysuppress the mammalian stress response," says Lee, who has investigated thestress response for nearly two decades. Working with graduate research assistantYanhong Zhou, Lee found that, in cell cultures, genistein blocks the activity ofa cellular protein, a transcription ac...

Soy Phytoestrogens Reduce Carotid Atherosclerosis As Much As Premarin

...fits to the standardPremarin therapy prepared from mammalian estrogens. "Phytoestrogens were as robust...e Medicine, compared the effects of treatment with mammalian estrogens-- Premarin -- with treatment with soy phytoestrogens in postmenopausal monkeys,all of whom...

Soy Protein With Phytoestrogens Inhibit Atherosclerosis Progression As Well As Premarin

...oestrogens work as well as Premarin-- the standard mammalian estrogen therapy. The research team headed by Mary S. Anthony, M.S., a research associateat the Wake Forest University School of Medicine, compared the development ofatherosclerosis on the walls of a group of abdominal arteries called the il...

Tiny Worm Reveals Workings Of Suspected Tumor Protein

...wants to go back and forth between thenematode and mammalian cells, mindful that his ultimate curiosity lies with thelatter. Editors, please note: a black-and-white photograph and diagram are available....

Researchers Identify Protein Critical To Urine Concentration

... protein in mice raises the possibility that other mammalian aquaporins have important physiological functions. "Deletion of each remaining aquaporin in mice is likely to be informative," he says, "as might the screening for aquaporin mutations in genetic diseases associated with abnormalities of fluid balanc...

Infant Dependency Drives Menopause, NSF-Supported Researcher Reports

...ivestock. It appears to be a universal feature of mammalian females. "Since female mammals are the primary caretakers of infants, we would expectmenopause to evolve whenever child-rearing is extensive and prolonged," Packersaid. Packer's co-authors are Marc Tatar, assistant professor in the BrownUnive...

Max Planck Scientists Report Molecular Details On The Interaction Of The Stress Hormone Corticotropin-Releasing Factor (CRF) And Its Receptor

...rvation confirmed by many groups that mammalian CRF-R1 does not discriminate between the naturally... frog CRF-R1 and to determine whether mammalian CRF-R1 could be rendered ligand-selective by introduction of amino acids recognized to ...

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