Jefferson Lab detector technology aids development of cystic fibrosis therapy
... But if everything works out, and we can make it a manageable disease, I think that would be really, really good," Lee says. The CFTR gene codes for a protein that controls the transport of chloride ions into and out of individual cells in the lungs, liver, pancreas, digestive tract, reproductive tract...Protein engineered to detect nerve gas
...r key. The computational process narrows down to a manageable few the vast number of possible mutations in the normal protein and their corresponding structures, to fit a particular molecule. Once the designs are narrowed down, the biochemists construct the proteins and test them for selectivity and binding pro...Drug that cuts off tumor's blood supply extends lives of colorectal cancer patients
...tor to be approved by the FDA, and we found it has manageable toxicity. So patients not only live longer, but their quality of life is also maintained." In the study, 813 patients with previously untreated advanced colorectal cancer were randomly assigned to two groups. In one group, 402 patients received irino...Genome-wide screen reveals new tricks of old genes
...rchers knew. "We had to do something else to get a manageable starting point," says Warren. So, using a technique she developed to identify whether a gene's loss causes the genetic material to become scrambled, Warren tested those 26 genes to see which of them seemed most likely to contribute to genetic instab...Genetic screening study at Stanford ID's most aggressive adult leukemia strains
...st and the least aggressive cancers, and is a more manageable number for screening in a doctor's office. This study joins a growing body of research relying on microarray analysis to distinguish between patients with otherwise similar cancers. The technique has been successful in breast, lung and liver tumors a...Researchers discover 1.2 million new genes in Sargasso Sea microbes
...rgasso Sea was thought to be an environment with a manageable number of microbes....Immerge reports PERVs most infectious to human cells not part of germ-line DNA of mini-swine
...ntinues to indicate that PERV appears to be a very manageable concern clinically, allowing us to continue our progress toward clinical xenotransplantation in the near future." The depth of Immerge's safety program is unique among other companies conducting xenotransplantation research. The company has previous...Rice centromere, supposedly quiet genetic domain, surprises
...nlike centromeres from other organisms, it is of a manageable size. Most centromeres are composed of vast stretches of what was once called "junk DNA," seemingly nonsense genetic sequences with no apparent coding function. "They're humongous," Jiang explains. The DNA within centromeres is "highly repetitive, a...UK science research to beat breast cancer
...orming unmanageable floods of clinical data into a manageable stream of relevant information that doctors can use more easily. It aims to overcome key scientific and technological barriers to the development of informatics systems that can help deliver quicker and more effective treatment for patients. The proj...New cause identified for incurable muscle condition
...ffered from the illness, which has no cure, but is manageable with treatment. In people with normal nerve-muscle interaction, every nerve impulse elicits a muscle response. The initial response is a localized electrical current, which in turn triggers sodium channels within the muscle to generate electrical imp...Engineered proteins will lead to 'synthetic biology'
...r key. The computational process narrows down to a manageable few the vast number of possible mutations and their corresponding structures, to fit a particular molecule. "We call these supra-astronomical calculations, because they can produce more possible combinations than there are particles in the known univ...Energy department awards $9 million for energy-related genomic research
...r -- but the Sargasso Sea is an environment with a manageable number of microbes, and researchers have initially begun studies on samples from there. The studies will enable scientists to discover biochemical pathways and organisms that may lead to the development of new methods for carbon sequestration or alte...Could one less cookie a day help the fight against fat?
...bring about weight loss, it represents a specific, manageable strategy that people can use to stop the current trend in our ever-fattening population, according to Hill, a researcher at the University of Colorado Health Sciences Center. This is the most urgent priority in addressing the obesity epidemic, he sai...American Physical Society March Meeting 2003
...lectricity to sunlight) and using cheaper and more manageable materials. The first generation cells used silicon wafers and commercial module efficiency values were about 10-15%. The second generation cells used thin film modules and efficiencies were about 5-9%. Last year the first of the third-generation devi...Emory Vaccine Research Center study identifies specific gene required for long-term immunity
...ving patients dangerously vulnerable to ordinarily manageable infections. Future investigations into SAP will focus on identifying precisely how it affects the ability of CD4+ T-cells to stimulate the production of long-lived plasma cells and memory B-cells....Scientists find fully differentiated blood cells remain able to switch identity
...ma cells that are resistant to treatment into more manageable forms of cancer. "We found that just two genes, EBF and Pax5, are turned off when B-cells are concerted into macrophages; Pax5 is a known oncogene implicated in the growth of B-cell lymphomas," Thomas-Tikhonenko said. "It's possible that by targetin...Identifying individuals at risk for Alzheimer's disease
...us to winnow down the general population to a more manageable pool of individualswith relatively higher risk for Alzheimer's. In this project, Martins and colleagues developed a set of tools for identifying such enriched populations. This work may impact on future clinical trials of anti-Alzheimer drugs....Gene profiles predict survival
... indicating that this technique should be entirely manageable for routine use," said National Cancer Institute (NCI) investigator Elaine M. Hurt, Ph.D., one of the authors on the study. DLBCL is the most common type of non-Hodgkin's lymphoma in adults. Standard chemotherapy for the disease is effective in only...Pinpointing the protein problem in Lou Gehrigs Disease
... medicines that will help ALS patients live with a manageable disease instead of a death sentence. The Rensselaer biochemists vital research has recently earned a $1 million, four-year grant from the National Institutes of Health. The NIH grant will support Colons study of the hereditary version of the disease,...... and higher-order structures condensing DNA into a manageable space -- has been known for some time," Wang says. "But structural and biophysical details of the system have not been clear. Nucleosomes seem to stand in the way of a genetic information-transfer process that happens millions of times a day in the...