Tag: "marker" at biology news

Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better

...is means that we can use PSA values as a surrogate marker in short phase II/III human trials as it is clear that PSA values are accurately reflecting the inhibiting activity of the lycopene and vitamin E on tumour growth. "What was particularly marked was that it was the low dose of both lycopene and vitami...

A liking for sweets, combined with novelty seeking, may predict alcoholism

...s yet been analyzed. Fourth, if sweet liking is a marker for alcoholism, how does it interact with other markers/genes to lead to a complete understanding of the underlying risk factors for alcoholism and their implications for prevention and treatment? Answering the preceding is akin to finding the holy ...

IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth

...d profile as shown by the expression of angiogenic marker V3 integrin. "Targeting this integrin could be a potential therapeutic approach for IBD," similar to approaches in other forms of chronic inflammation, Danese said. "These results provide the initial material and conceptual framework for investigatin...

Chemical signals health of brain cells Symposium

...ence Center, Bethesda, MD. NAA is best known as a marker for the health of neurons, brain cells, which can ...navan disease Use of NAA as a neuronal integrity marker for neurological diseases by magnetic resonance spectroscopy N-acetylaspartylglutamate, the most a...

Researchers identify distinctive signature for metastatic prostate cancer

...hog activation perhaps measured by detecting some marker in the blood to distinguish indolent from metastatic disease, they could know to treat the metastatic form and not the indolent form," he said. "If the indolent form, for example, were detected in older men, it might not be as necessary to perform a...

The impact of genetic variations on the treatment of early rheumatoid arthritis

...archers examined patients for a particular genetic marker in the HLA region associated with susceptibility to RA (the so-called shared epitope), as well as genetic variants in the TNF gene region. Results of genetic testing were then correlated with treatment responses. Among patients treated with standard-...

Single isolated mouse skin cell can generate into variety of epidermal tissues

... tag these "slow cycling" cells with a fluorescent marker and watched them travel out of the niche and move down to the bulb of the hair follicle to form new hair or move up to create new skin epidermis, lending more evidence to the idea that these were stem cells. But the researchers didn't know if hair an...

New imaging technology at Joslin shown to detect early signs of type 1 diabetes

...ry condition known as "insulitis"). A very early marker of this inflammation is increased permeability (leaking) of the tiny blood vessels surrounding and within the islets. Until recently, the only way to track type 1 diabetes in its earliest stages was to measure blood levels of autoantibodies (the imm...

JCI table of contents: 1 September, 2004

...s were such that the NF-kB gene was turned on, the marker gene, luciferase, would be expressed. Such expression can be seen clearly as the luciferase gene product glows. Under hyperoxic conditions, the researchers found, that luciferase expression was higher in the neonatal lung than in that of the adult. E...

Improving crops without genetic modification natural variation holds the key

...ining traditional breeding techniques with genetic marker analysis, the authors identified a number of wild tomato genomic regions that dramatically increased yield. Their results demonstrate that an approach based on biodiversity--which takes advantage of the rich genetic variation inherent in wild relativ...

Researchers report new gene test for isolated cleft lip and palate

...gly believe is happening is the valine serves as a marker for some other mutation nearby within the gene that's really doing the deed," he continued. "In a sense, the valine is hitchhiking with the actual mutation." At this point, the researchers stepped back and looked more broadly at the gene and flankin...

Nucleic acid-amplification testing further safeguards nation's blood supply

...HIV-1 antigen testing and a test for a nonspecific marker for HCV. Blood donations continue to be screened with antibody tests for HIV, HCV, and other viruses, which helps ensure the safety of the blood supply. "NAT not only improves the safety of our already safe blood supply, but the technology can be q...

Sweet success in targeting sugar molecules to cells in living animals

...ic pathways, and it was thought that integrating a marker into a specific sugar molecule would inevitably disrupt its processing in the cell. To overcome these problems, Bertozzi and her colleagues developed a chemical technique to tag sugars in a way that does not disrupt a cell's biology and is highly spe...

Hopkins scientists use blood proteins to detect ovarian cancer

...s and ultimately narrowed the search for potential marker candidates to the three proteins, one of which (IT...ncer patients have high blood levels of a standard marker called CA125," says Zhen Zhang, Ph.D., associate professor of pathology at Johns Hopkins. "But comb...

Alcohol-use and depression among pregnant and postpartum women

...cohol use and depression during pregnancy can be a marker for women at risk for later difficulties with alcohol and depression, which can adversely affect both women and the development of their children. Children whose mothers have alcohol use disorders and/or depression tend to have more physical and psy...

Schizophrenia gene variant linked to risk traits

...function than people with the 'G' variant. The 'G' marker was associated with relatively more 'efficient' processing in the prefrontal cortex. Those who inherit the 'G' variant scored higher on verbal and cognitive tests than those who have two of the 'A' variant. Scientists think the less common 'G' varian...

Depression traced to overactive brain circuit

...f its ability to unmask what appears to be a trait marker for major depressive disorder, the researchers suggest that tryptophan depletion may be a useful tool for studying the genetic basis of depression. "Since brain function appears to be disregulated even when patients are in remission, they need ...

New technique helps scientists reveal interactions between genes and drugs

...ld and sometimes aren't. When a particular genetic marker is consistently passed from parent to child at the..., that tells scientists they need to look near the marker for a gene that changes sensitivity. The initial test of the new approach found connections be...

Location of potential familial lung cancer gene discovered

...ility gene or genes is co-inherited with a genetic marker on chromosome 6. Markers on chromosomes 12, 14, and 20 also indicated possible linkage to lung cancer susceptibility, although the results were not as strong. Identifying the locus was a critical first step, but more work needs to be done. "The ge...

NRH1 and Wnt signaling come together in convergent extension

...xis and the failure of mesodermal and neural plate marker gene expression to converge on the midline or extend axially. Interestingly, interfering with NRH1 function by introducing morpholinos to block production of the NRH1 protein had similar effects the inhibition of convergent extension. That both gain...

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