Once a renin cell, always a renin cell
...age. The researchers generated mice with a genetic marker that allowed visualization of renin-expressing cells even after the cell had differentiated into a non-renin-secreting cell type. Experimental manipulations known to recruit renin-expressing cells demonstrated that adult cells that were descendants o...Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
...rily after surgical excision. There is no protein marker test for kidney cancer as there is for prostate cancer with the PSA test....Insulin-producing pancreatic cells are replenished by duplication
...ouse whose beta cells contained a telltale genetic marker that could be switched on by administering the dru...ifen to the adult mice, they can easily follow the marker to determine whether it is inherited by subsequent generations of beta cells. If it is inherited, th...Genetic signature may predict recurrence in colon cancer patients
RARITAN, NJ, APRIL 29, 2004 A new prognostic marker has shown potential to predict recurrence in certa...used gene expression profiling to identify the new marker a 23-gene signature which may predict disease recurrence in patients initially diagnosed with Duke...Chlamydia in men now also linked to infertility new findings
...tes in couples where the man had IgG antibodies a marker of previous or persistent infection by Chlamydia trachomatis[2], one of the most common sexually transmitted diseases. The researchers tested 244 infertile couples attending their infertility clinic for the antibodies. For those couples where one par...Specifying alcohol-related brain-damage among heavy social drinkers
...tal white matter NAA generally considered to be a marker of neuronal damage was lower in heavy drinkers than light drinkers, and was associated with lower executive and working memory functions. "Although the men and women who drank heavily for many years demonstrated fewer changes in brain metaboli...Immunity gene predicts severe adverse drug reaction
... new drugs, said the researchers. A single genetic marker predicted with 100 percent accuracy those who could safely take carbamazepine, the team reported in the April 1, 2004, issue of Nature. Individuals with a particular version of the immunity gene who took the drug suffered the devastating reaction in ...Study points to a promising new test for myelodysplasia, a blood disorder often leading to leukemia
...noted that the new DNA test is the first molecular marker capable of distinguishing MDS patients as a group from patients with nonmalignant bone marrow disorders. "Currently available markers are applicable in less than 50% of MDS patients," he said....Combination therapy drives cancer into remission
...herapy with mice, weight loss is the most reliable marker for whether a particular treatment is tolerable or unacceptably toxic. The mice in the new study tolerated the rapamycin plus doxorubicin combination therapy well, experiencing loss of less than 10% of their body weight. The Importance of "Personali...Researchers model embryo implantation and tumour metastasis in fruit flies
...on and the Ontario Innovation Trust. Looking for a marker that would enable him to see live cells - particularly those of the extraembryonic tissues - as they change their shape and motion, Dr. Reed saw the molecules that he would eventually identify as basigin. The molecules were attached to the membrane ...MGH study finds female mammals produce egg cells into adulthood
...ries of adult transgenic mice that express a green marker protein in all of their cells. Several weeks later the grafted ovaries in the transgenic mice were found to contain hybrid follicles consisting of normal follicular cells surrounding green oocytes. These results demonstrated that transgenic (green) ...Rimonbant shows promise in addressing multiple risk factors
...ant reduction in abdominal obesity, an independent marker for heart disease. Dramatic improvements were also seen in lipid profile with a 23% increase in HDL-cholesterol (good cholesterol) and a 15% decrease in triglycerides. Improvements in glucose tolerance and insulin levels were also observed. In ano...Biology behind homosexuality in sheep, study confirms
...analysis for the study, said scientists now have a marker that points to whether a ram may prefer other rams over ewes. "There's a difference in the brain that is correlated with partner preference rather than gender of the animal you're looking at," she said. About 8 percent of domestic rams display prefer...New imaging technique developed to identify breast cancer
...ns Hopkins have for the first time used a chemical marker detected by proton magnetic resonance spectroscopic imaging (MRSI) to successfully diagnose breast cancer. The diagnostic technique produces pictures of choline within breast tumors. In the study, researchers from the Russell H. Morgan Department ...Protein inhibits cell growth, may contribute to breast cancer
...h has applied for a patent on the use of cdk6 as a marker for cancer and as a target to control cell growth....Drug addiction, learning share common brain protein
...ested. The gene might therefore represent a useful marker for measuring such differences. The researchers will next examine the effects of PSD-95 on the addictive behavior of mice, Caron said. For example, they will test whether PSD-95-deficient mice self-administer greater amounts of cocaine than do nor...Possible mechanism for link between diabetes and Alzheimer's disease discovered
...er's disease and has been suggested to be an early marker of this disease. On the other hand, the NIRKO mice showed no changes in the proliferation or survival of neurons, memory, or basal brain glucose metabolism, suggesting that insulin resistance may interact with other risk factors to promote full-blown...Mice cloned from olfactory cells
...ith olfactory sensory neurons tagged using genetic marker molecules. Using standard cloning techniques, the researchers in Jaenischs laboratory then isolated individual neurons, removed nuclei from the tagged cells and introduced the nuclei into mouse eggs from which the nuclei had been removed. When these ...Lake restrictions make lakeshore property more valuable
...ed on property value, which he says is an indirect marker of the economic value of the ordinance. Property value, he explains, can capture competing positive and negative effects of the ordinance on lakeshore residents, such as the assurance that the lake will be protected from future overdevelopment, but a...Study of dyslexic brain finds three word forms responsible for reading success
...iences. "We are beginning to study our genome-wide marker scan in detail to identify more locations where putative genes for dyslexia may reside. What is exciting is that the behavioral measures (of sound, visual, and meaning word forms) used as clues to find those gene locations are yielding instructional ...