Research points in new direction for cancer clues
...ntial of fibroblast-specific-protein 1 (FSP1) as a marker for cancer metastasis. This lab had developed a mouse that, under influence by FSP1, selectively expressed Cre in fibroblasts alone. By crossing the two strains of mice, a new strain of animal was developed that expressed Cre only in the fibroblasts...Study demonstrates altered angiogenic proteins in preeclampsia patients
... to 12 weeks of pregnancy, appear to be a specific marker for preeclampsia and no other adverse outcomes of pregnancy. This investigation was led by Massachusetts General Hospital investigator Ravi Thadhani, MD, MPH, in conjunction with Karumanchi. A coauthor of the NEJM paper, Thadhani is also an assistant...Could memory performance and spatial learning be genetically based?
...the index of spatial accuracy (SpA). Linkage map, marker regression and interval mapping analyses were done to generate a likelihood ratio statistic as a measure of the significance of a possible QTL. A backcross analytic design was used to perform both the permutation test as well as the QTL analysis. Gen...Inflammation marker predicts colon cancer
C-reactive protein (CRP) -- a marker of inflammation circulating in the blood already associated with increased risk of heart disease -- can also be used to identify a person's risk of developing colon cancer, according to a Johns Hopkins study. Results of the study, published in the F...MBL scientists confirm evolutionary exception
...hers identified four copies of a target P. roseola marker gene, however each gene was on a separate chromosome and all were quite a bit different from each other. These results, consistent with asexual reproduction, eliminate the possibility that bdelloids reproduce sexually and thus confirm that the organi...Other highlights in the January 21 issue of JNCI
... drugs, suggesting that the gene might be a useful marker for tailoring chemotherapy or that it is a potential target to improve sensitivity to chemotherapy. Folate is a form of a B vitamin that is critical for DNA synthesis, DNA repair, and epigenetic regulation. About 35% of the general North American po...JCI Table of Contents, January 15 2004
... with bone marrow labeled with a fluorescent green marker protein. In these mice, cells derived from bone marrowderived stem cells fluoresce green, while those cells that reside in the lung do not. Most of the collagen-producing fibroblasts observed in the lungs of these mice fluoresced green, indicating th...Predicting progression of common cancers
...s--Chang et al. used this signature as a surrogate marker to measure how much tumors may be like wounds. When they compared the wound-like genetic signature with the expression profiles of various clinical tumor samples, they found the signature was always present in certain cancers--prostate and liver cell...Early identification of kidney disease cost-effective only when directed at high-risk patients
...ally high levels of protein in the urine an early marker of kidney malfunction and premature death should be limited to those with other risk factors and older Americans, a Johns Hopkins study indicates. "Given the relatively inexpensive and safe nature of urine testing for proteinuria, physicians might...Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
...rily after surgical excision. There is no protein marker test for kidney cancer as there is for prostate cancer with the PSA test. "We used a common laboratory procedure to test the urine of 50 patients with kidney cancer," explained Fox Chase molecular biologist Paul Cairns, Ph.D., lead author of the s...Alcoholics with antisocial personality disorder have blunted emotional reactivity
... and failure to adhere to societal norms, may be a marker for underlying deficits in emotional reactivity and related impairment in frontal-limbic processes." Although a number of studies have identified a strong relationship between child and adolescent conduct problems and drug use, Miranda added, little...Map of genes in plant root yields new tool for exploring tissue development
...he identity of specific cells was made possible by marker genes the researchers attached to genes that were characteristic of each type of cell. Those marker genes produced a telltale fluorescent protein when the genes were switched on, which could be used t...Mustard-root map breaks new ground tracking gene expression
...they developed into specific tissue, they attached marker genes to genes characteristic of each of five different cell types or tissues. The marker genes produce a tell-tale, and therefore traceable, green fluorescent protein (GFP) when the gene th...New method of identifying and isolating stem cells developed
...ells) in mice that had been tagged with a chemical marker could travel out of the niche, and move down to the bulb of the hair follicle to form new hair or move up to create new skin epidermis. But scientists were unable to isolate these label-retaining cells, and hence had only a scant view of the properti......amino acid glutamate, which most think serves as a marker for protein-rich foods. Glutamate also is the main ingredient in the commonly used flavor additive MSG (monosodium glutamate), which may explain the additive's appeal. Taste research has attracted the attention of researchers like Liman who a...Chromosomes are 'nibbled' before they fuse, researchers report
... Instead of random damage, she discovered that the marker at the very end of the chromosome was most likely to be lost, and the marker closest to the chromosome's center the least likely. "If fusion and breakage was the primary mech...Duke researchers link nitric oxide, vessel health
...ociation between changes in nitrate, a biochemical marker of nitric oxide production, and physiological chan...esearchers demonstrated that exercise improved the marker in patients at risk for developing cardiovascular disease. In their pilot study, the researchers lin...New drug target and biomarker for advanced childhood cancer discovered
...hat provides a new target for treatments and a new marker for the disease. Separately, researchers reported data on the crystal structures of two kinase proteins implicated in multiple cancers. The data on structure provides valuable information for the design of cancer therapeutics targeted at these prot...Proteins may help identify patients who will respond better to treatments in certain cancers
...esearch and Treatment of Cancer (EORTC). Molecular marker expression phenotype is an independent prognostic ...py than others. Investigators looked at molecular marker expression profiles in 402 patients with head and neck squamous cell carcinoma. The study focused on......al networks give birth to heavier infants -- a key marker of viability -- than their more isolated peers. It...educes basal levels of the hormone cortisol, a key marker of stress. Grooming has also been shown to reduce heart rate in some monkey species. Nevertheless, t...