New pathway discovered at Stanford provides insight into heart disease
...nford University School of Medicine. Now that this marker of cardiac dysfunction, known as the APJ-apelin pa... was one called BNP, already known to be the first marker of heart disease to date. While this provided some confirmation of their technique, far more intrigu...Some re-established elk herds lack genetic diversity of ancestors
...tory. "We use microsatellites as a kind of flag, a marker for what a population has gone through in the past," Rhodes said. Wildlife biologists today use microsatellites to study a host of population parameters, including animal migration patterns, parentage in animal populations, and, like Rhodes, the gene...Higher blood levels of sitosterol may be associated with increased risk for coronary events
... to determine if sitosterol might play a role as a marker for increased risk of heart disease."...JCI Table of Contents, November 3, 2003
... of human CD4+ memory T cells and can be used as a marker to identify this cellular population. VLA-1 is also important in the ability of CD4+ memory T cells to recognize and mount a response to previously encountered antigens. Approximately 1-4% of CD4+ T cells were shown to express VLA-1 and following T c...Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers
...state cancer development, machine vision is a good marker for discerning subtle nuclear changes that occur d...t to have potential as a diagnostic and prognostic marker for both early detection and prevention," she said. Results from this study have shown that normal o...Scientists determine identity, cell locale and quantity of nearly all proteins in an organism
... yeast strains to tag the proteins with a standard marker that allows purification and measurement of the abundance of the protein. When the results of the two parallel approaches were pooled, the team was able to identify the type, cell location and abundance of about 80 percent of the yeast's proteins. T...Stanford research finds gene variations that alter antidepressant side effects
...niversity Medical Center have identified a genetic marker that can explain why some people experience side effects to common antidepressants while others do not. They also found that a key liver enzyme involved in breaking down these antidepressants surprisingly played no role in the development of side eff...NSF'S 'FIBR' to mix disciplines, use breakthroughs on 5-year explorations into biology's mysteries
...l Modeling and Informatics," merging genetic data, marker proteins, modification of genes, mathematical models, and computerized visualization to create a "computable plant" and study the formation of plant structures; University of California-Irvine (lead), California Institute of Technology, Huntington Bo...New study shows why hypertension affects black males disproportionately
...ogression, and etiology of HT, and as a prognostic marker for cardiovascular disease. The findings in this cross-sectional investigation may be suggestive that the establishment of clinical disease may occur much earlier than believed. On the basis of public health statistics, it is conceivable that these ...Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures
...y low levels of prostate specific antigen (PSA), a marker associated with malignancy. Cells treated with a similar compound that was not a telomerase inhibitor formed large tumors with high PSA levels. "Telomerase is widely appreciated as a promising target for therapy," said Dr. David Corey, professor of p...Discovering new regulators of the immune system
...ignalling when expressed. Normally, a cell surface marker called CD69 is up regulated when T-cell receptors are activated. However, the researchers selected cells that, when given a new gene to express, failed to up regulate this protein. They then checked that this repression was caused by the introduced g...Genetic clues may show which women face breast cancer risk from HRT
...actor for breast cancer and has been proposed as a marker for breast cancer risk. "Our research is promising. We already know that only some women who use hormone replacement therapy with estrogen and progestin go on to develop breast cancer," says Giske Ursin, M.D., Ph.D., associate professor of preventive...New blood test uncovers individual risk for lung cancer
...hat smokers who carry the newly discovered genetic marker are around 120 times more likely to get lung cancer than non-smokers who do not have the risk factor. A simple blood test based on these findings will be able to detect smokers who are at especially high risk of developing lung cancer. The findings...Emory scientists track down immune sentinel cells with gene gun
...cob's group used transgenic mice engineered with a marker gene that can be easily detected by staining, but only when that gene is rearranged by an external signal. They shot the trigger signal DNA encoding a specialized bacterial enzyme - into the skin of the mice. All the cells in the skin received the ...Creation of new neurons critical to antidepressant action in mice
...ated ones, showed a 60 percent boost in a telltale marker of neurogenesis in a key area of the hippocampus. To find out if the observed neurogenesis is involved in antidepressants' mechanism-of -action, Hen and colleagues selectively targeted the hippocampus with x-rays to kill proliferating cells. This red...UNC studies identify key genes involved in blood vessel development
...and Patterson looked at the gene flk1, a molecular marker for early endothelial cell precursors. "Flk1 is important because it's a receptor for vascular endothelial growth factor, which is an angiogenic factor," Patterson said. "But it's also important to us because it's the first gene that gets turned on i...Stem cell death gives clue to brain cell survival
...nded instead a protein called nestin. "Nestin is a marker for a particular stage of neuronal development," says Dr. Bieberich. "Nestin-bearing cells will develop into neural cells such as our neurons or astrocytes or other cells. So it makes sense that the cells that inherit nestin, but not PAR-4, will surv...Swimming can contribute to rebuilding bone strength
...y limited to noninvasive radiography or serum bone marker assays. Thus, it is difficult to investigate the effects of exercise mode on bone by using these techniques. There is difficulty in equalizing the energy expenditure or total work of different modes of exercise, which has lead to a lack of studies i...Inflammation blocks impact of heart healthy diets for some
...irculating blood levels of C-reactive protein -- a marker of inflammation already linked to increased risk of heart disease -- may predict who might benefit from a reduced-fat, low-cholesterol diet and who might not. For the study, a team led by Thomas "Tate" P. Erlinger, M.D., M.P.H., assistant professor...Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
...partments. C-reactive protein is a non-specific marker of inflammation. According to Dr. deFilippi, level...study for patients is the fact that there is now a marker that can be followed over time. "In the follow-up of patients, we can ascertain when a patient has c...