Making of mouse marks move toward 'mitochondrial medicine'
...ntists working together across the globe. The work marks one of the most successful forays yet into the manipulation of DNA in the mitochondria, cellular structures that play a vital role in creating energy that power cells. "We used an approach that had a high risk of failure, but one that will now provi...Molecular mechanisms that trigger flowering in spring
...ttached to a small protein called ubiquitin, which marks it for degradation by the proteasome. Thus in short days, although CONSTANS mRNA is present, the protein is absent. The expression of CONSTANS mRNA therefore represents a light sensitive rhythm, similar to that proposed by Bnning, which triggers flow...New genomics tool boosts diabetes research
...h are known to cause type 2 diabetes. The research marks the first time that human organs, in this case the pancreas and liver, have been analyzed in this way and opens the door to similar studies of other organ systems and diseases. The work, published in the Feb. 27 issue of the journal Science, could le...Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
.... The research, which has implications for humans, marks the first time a link between a specific fetal lung protein and labor has been identified, said Dr. Carole Mendelson, professor of biochemistry and obstetrics and gynecology and senior author of the study. The paper appears in an upcoming issue of th...Ribozyme package effective against hepatitis B virus
...of hepatitis B virus in the livers of mice. "This marks one of the few successful in vivo, or in-animal, models of an effective therapy to reduce the production of hepatitis B virus," said Gary Clawson, M.D., Ph.D., professor of pathology, biochemistry and molecular biology, Penn State College of Medicine...Damania of UNC receives Elion cancer research award
...004 AACR Annual Meeting in Orlando, Florida. This marks the second year in a row that the award goes to a UNC researcher. Last year's Elion recipient was Dr. Yi Zhang, as was the 1999 winner, Dr. Yue Xiong. Begun In 1993, the $50,000 award recognizes research excellence in cancer etiology, diagnosis, trea...JCI table of contents, 2 April 2004
...to IL-10 restored CD8+ T-cell activity. This work marks the pivotal role that these regulatory T-cells play in controlling hepatic CD8+ T cell action during HCV infection and that the concomitant appearance off these two cell types may be the main factor in the establishment of chronic infection. TITLE: ...New software developed at Rensselaer predicts promising ingredients for new drugs
... one of a new breed of drug discovery methods that marks a shift in industry practice--a shift away from cell-based assays performed in the lab toward math-based models calculated on the computer. "Our program allows researchers to 'crash test' lots of molecules quickly and inexpensively," Breneman ...Genetic basis of hereditary nerve disorder revealed
... Genetics and professor of medicine at Duke. "This marks the first time that mitochondrial fusion has been implicated in a human disease and opens up a whole new area of exploration for the basis of peripheral neuropathies in general." Several years ago researchers at the Duke Center for Human Genetics led...Patagonia's coastal wildlife receive a protective boost by Argentine government
...overfishing and unregulated tourism. The agreement marks a significant milestone in sealing political commitment to the Patagonia Coastal Zone Management Plan, which was spearheaded by the Bronx Zoo-based Wildlife Conservation Society (WCS) and Fundacin Patagonia Natural, an Argentine conservation group. T...Study marks increased trends in infectious disease occurrences in our oceans
... to understand disease dynamics in the oceans, and marks the first quantitative use of normalized trends in the scientific literature to test an ecological hypothesis. The study found increased reports in scientific literature of disease outbreaks for turtles, corals (non-infectious bleaching), mollusks, m...Genetic signature may predict recurrence in colon cancer patients
... diagnosed with Dukes' B colon cancer. The study marks the first significant application of genomics in searching for molecular markers for colon cancer prognosis and is also the subject of an editorial in the Journal. While the standard of care for patients with Dukes' B, or Stage II, colon cancer s...Plant disease under the homeland security microscope
...djunct professor with Texas Tech University, which marks GPDN's southern boundary. Other GPDN cooperators include: Colorado State University, Montana State University, North Dakota State University, Oklahoma State University, South Dakota State University, Texas Tech, University of Nebraska, and University...Chemical reaction in birds provides sense of direction during migratory flights
...en the birds moved in the cages, they left scratch marks that were counted subsequently by the researchers and analyzed. To produce artificial oscillating fields, the researchers fed high-frequency currents from a signal generator into a coil that surrounded four test cages. The coil, with a diameter of a...MBL researcher and science teacher visit Siberia to study climate, excite children about science
...he Lena River and PARTNERS project is earning high marks from the students. "It has made it easy to get these kids excited about science," says Holmes. "Their involvement in the PARTNERS Project gives the science they study some relevance, and therefore helps it stick. When I was young and studying scien...Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
...r cell invasion and metastasis. This Phase I trial marks the start of an innovative collaboration between the U.S. government, an academic research center (Fox Chase) and a biotech firm (Wilex) to rapidly move a laboratory discovery to the clinic for use in patients. This is the first of two clinical trial...First ever standards linking climate change, biodiversity and poverty seek global peer review
...lopment and biodiversity conservation. This draft marks the beginning of a broad, international review. Community groups, non-profit organizations, companies, academics, government agencies and individuals are encouraged to review this draft and suggest improvements. All types of comments are welcome: cri...Espionage may have driven the evolution of bee language according to UCSD-led study in Brazil
...tion, detected and preferentially oriented to odor marks deposited by a competitor and then rapidly dominat... species were able to distinguish their kin's odor marks from the marks of the other species. "The victim species preferred their own odor marks and av...AAAS 2004 salary survey: Despite long hours and low pay, life scientists love their work
...n the pharmaceutical industry give themselves high marks for job satisfaction, compared with 62 percent of those in the biotechnology industry. The disparity in pay for men and women persists. In academia, the income gap has shrunk from 35 percent in 2001 to 24 percent in 2004. In nonacademic settin...New designed paclitaxel analog kills more cancer cells than natural product
...ngston. The discovery by the cross-university team marks a significant step along the road to this objective. Kingston explains that paclitaxel binds to tubulin, a protein molecule that forms the backbone of microtubules. Microtubules are a cell component whose duties include allowing chromosomes to move...