New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
...d accumulation of abnormal white cells in the bone marrow and the blood, resulting in anaemia, bleeding and ...t patients will be able to avoid the need for bone marrow transplants." Arsenic compounds have been used in medicine for thousands of years, dating...JCI table of contents September 15, 2004
...itoneal macrophages and immature DCs from the bone marrow of Cot/Tpl2/ mice showed increased IL-12 expression in response to CpG-DNA. Northern blot analysis and gel shift assays demonstrated that enhanced IL-12 levels occurred at least partially through loss of transcriptional repression. In vivo, OVA immun...Bone marrow cells routinely help with wound healing
Bone marrow produces cells that not only help fight infection,...n. Previously, researchers had not known that bone marrow contributed to the development of new skin in wounds. The findings will be published in the Sept. 3...Select research highlights from current AACR journals
...cancer therapy for ovarian cancer and certain bone marrow tumors. In rat models for fibrosarcomas, Abdel-Wahab et al. documented that heat treatment with warm water heightened the response of tumors to high doses of melphalan. The effect was synergistic, but not related to heat-promoted increased uptake of ...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...) scans, magnetic resonance imaging (MRI) and bone marrow biopsy. "There are many types and subtypes of lymphoma, some of which are easy to detect, but many that are very difficult to identify," says Antonio Giordano, M.D., Ph.D., director of the Sbarro Institute at Temple and one of the study's principal ...APS awards more than $140,000 to minority students of physiology
...fewer fat cells and more bone forming cells in the marrow cavity. This work may provide a new target for preventing the bone loss associated with aging and/or menopause. Adrienne Bratcher University of Louisville School of Medicine Ms. Bratcher is conducting research in the area of hypertension. She is...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...iology." The work has also revealed that the bone marrow via dendritic cell precursors, which are produced in the marrow is involved in angiogenesis. This observation raises clinically important questions as to the effec...T. rex owes its giant size to the ultimate teenage growth spurt
...is is due to the way these large bones form: their marrow cavity expands and changes shape as they grow, erasing some of the internal lines. This study, however, focuses on smaller, nonweight-bearing dinosaur bones, including ribs, gastralia, and fibulas. These bones do not develop hollow cavities or remode...Leukemia stem cells identified by Stanford researchers
...- such as the blood-forming stem cells in the bone marrow that produce both red blood cells and immune cells. Instead, Jamieson found that the cancer started when a normal adult cell mutated and gained the ability to self-renew. Another surprise has to do with how chronic myelogenous leukemia develops. Most...Joslin Diabetes Center launches research section on developmental and stem cell biology
... very interested in adult stem cells, such as bone marrow or brain stem cells, which exist in tissues after ...ly types of stem cells currently used through bone marrow transplantation for the treatment of human diseases (including leukemia, lymphoma, immune deficiency...Fundamental change to Immunology 101
...types begin. A progenitor cell must leave the bone marrow to seed the thymus, eventually giving rise to T ce...o do this, though, the thymus periodically imports marrow T-cell progenitor cells via the circulatory system. The cell types that travel from the marrow to th...Babies with DiGeorge syndrome saved by immune supression, thymus transplant
...ive a thymus transplant because some of their bone marrow cells had spontaneously transformed into rogue T c...n, immature white blood cells from the baby's bone marrow migrate to the thymus tissue, where they are trained to differentiate between germs and the body's o...JCI table of contents, 2 August, 2004
...ar repair in mice that were transplanted with bone marrow from mice that are unable to make immune cells, th...eficient mice. Mice transplanted with normal bone marrow cells showed greatly exacerbated the vascular injury compared to mice transplanted with bone marrow ...New UCF researchers, college will help fight Alzheimer's disease, cancer
...esearch will show that taking stem cells from bone marrow in a patient's hip and injecting them into the brain can help fight Alzheimer's and Lou Gehrig's diseases, strokes and blindness. Sugaya previously taught at the University of Illinois at Chicago. In his prior research, which was cited in the Wall St...Patients' cells from tumors, the immune system merged for customized cancer therapy
... cells," said David Avigan, M.D., director of bone marrow transplantation at Beth Israel Deaconess Medical Center, and the lead author of the Clinical Cancer Research article. The immune system develops T cells, which are white blood cells, to recognize foreign proteins, cells, and other matter that causes...New drug shows promise against Gleevec resistance in mice
...f mice with CML. In tests with cultured human bone marrow cells, the researchers showed that the drug inhibits the proliferation of bone marrow progenitor cells that are positive for BCR-ABL in patients who are resistant to Gleevec. "The bottom...Gene profiles could improve acute leukemia diagnosis and lead to better treatments
...rnal Blood . AML is a cancer that arises in bone marrow hematopoietic stem cells (HSCs) or progenitor cell... diseased cells. HSCs are parent cells in the bone marrow that can potentially give rise to any one of the various types of blood cells. Progenitor cells are ...Warren Pharmaceuticals publishes results of preclinical evaluation
...iator of tissue protection. By separating the bone marrow activating function of EPO from its tissue-protective function, we have been able to target only tissue injury." said Anthony Cerami, Ph.D., CEO of Warren Pharmaceuticals. "Our collaboration with Warren Pharmaceuticals has generated important advance...Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
...the same time receive an infusion of modified bone marrow cells that would have a form of AGT protein able to resist the inhibitors, which could protect the patient from some of chemotherapy's more toxic side effects. Daniels and Tainer had already solved the free-form structure of AGT (not bound to DNA), ...Macrophages, not stem cells, correct liver disease by fusion
...e, found that mature macrophages derived from bone marrow stem cells, and not bone marrow stem cells themselves, are what fuse with diseased liver cells, ultimately curing a genetic liver di...