Tag: "marrow" at biology news

New gene therapy shows promise for hemophiliacs

... back to the patient, where they seek out the bone marrow and the spleen and start to divide. "The results we've seen in our mouse studies show long-term attainment of robust levels of factor VIII that would be therapeutic in a human," said Hebbel. "While we typically would call a five percent increase in ...

Magnetic tag lets scientists track stem cells in living rat

...tem cells from bone marrow. (Stem cells from bone marrow and blood have been used for decades in cancer treatments and more recently for some inherited metabolic disorders.)...

Scientists use gene therapy to correct sickle cell disease in mice

...uman hemoglobin and normal mouse hemoglobin. Bone marrow containing the defective human beta-hemoglobin gen...After adding the anti-sickling gene, the corrected marrow was then transplanted into other mice with sickle cell disease whose bone marrow had been removed by...

Gene therapy corrects sickle cell disease in mice, Science authors report

...rring an anti-sickling variant of the gene to bone marrow with a viral delivery system. Once there, the anti...fficult to transduce an anti-sickling gene to bone marrow because it is so large, and then the expression level of this gene was very low and often 'silenced'...

Durable responses reported with Bexxar

...cine and co-director of the leukemia/lymphoma bone marrow transplant program at the University of Michigan C...a is a form of cancer that affects the blood, bone marrow and lymphatic tissues. NHL currently is the sixth leading cause of death among cancers in the Unite...

Researchers identify potential for prenatal gene therapy

...ultipotent adult progenitor cells (MAPCs), or bone marrow stem cells, engraft and differentiate into brain a...e possibility of future clinical use of adult bone marrow stem cells in attempts to correct neurological, hepatic, muscular and possibly other types of congen...

Scientists reveal role for nitric oxide during brain development

...atopoiesis, the process whereby stem cells in bone marrow proliferate and the resulting blood cells differentiate into specialized types (e.g. red blood cells, white blood cells, etc.). Fruit flies, frogs, mice, and humans all have similar sets of enzymes that produce nitric oxide. Thus, Enikolopov and his ...

Scientists identify cells necessary for tumor angiogenesis

...ogenesis occurs when precursor cells from the bone marrow are mobilized and recruited by VEGF (vascular endo... precursor (CEP) cells are mobilized from the bone marrow to contribute to angiogenesis in wound healing. They used the findings from an earlier Memorial Sloa...

Highly specific biological agents attack mechanisms of treatment resistance

... all signs of leukemic cells in the blood and bone marrow disappeared. Remission was sustained for four months on average; two patients stayed in complete remission for more than a year. Typical side effects of chemotherapy such as fever, nausea, and vomiting did not occur at higher-than-expected levels, su...

Researchers identify pathogen-specific gene response in human immune cells

... an immune response. These cells arise in the bone marrow but migrate to and seed tissues throughout the body. Before dendritic cells encounter an infectious agent, they are "immature," and act as roving sentinels of the immune system. Upon an encounter with an infectious agent, the dendritic cell reaches m...

University of Ulster spearheads giant leap forward in medicine

...ckle cancer tumours and leukaemia and protect bone marrow against damage during chemotherapy. Professor Shaw... against leukaemia and reducing the damage to bone marrow from chemotherapy treatment. Professor Shaw said: "This could be a giant leap forward for medicine. ...

Stem cells guided down blood's developmental pathway

...t therapies to treat cancers of the blood and bone marrow such as leukemias and myelomas. "This is not somet...and gene products characteristic of blood and bone marrow cells in the body. Moreover, these precursor cells go on to form colonies of white blood cells, red ...

T cell responses in aplastic anemia

...re decline of all blood cell lineages in which the marrow is deficient in hematopoietic cells. For this reas...hese authors have prepared T cells from within the marrow of 5 people with serious but treatable aplastic anemia. Cloning and DNA analysis of the T cell recep...

Structure solved by scientists at The Scripps Research Institute marks important milestone in effort to develop HIV vaccine

...m the virus itself. First identified in the bone marrow of a 31-year-old male who had been HIV positive without symptoms for six years, b12 demonstrates the human immune system is capable of raising antibodies that are effective against HIV, and scientists will now be investigating the ways in which this ...

Israeli teams grows heart cells and insulin producing cells from human embryonic stem cells

...cently reported on the use of stem cells from bone marrow to repair mouse hearts, Drs. Gepstein and Itskovitz-Eldor's research is a step forward in two important ways. It is the first time that human, as opposed to mouse stem cells, have been induced to form proto-heart cells. In addition, it is the first...

Yale researcher testifies in support of embryonic stem cell research

.... She recently discovered adult stem cells in bone marrow that can create new liver, lung, gastrointestinal and skin cells, and possibly any other organ in the body. "While I am very excited about this research, it is important that the subcommittee understand that adult stem cell research is not a substitu...

Researchers identify gene for rare form of leukemia that strikes infants

...les, as it is difficult to get a large enough bone marrow sample from babies....

Blood vessels found to signal chain of destruction in bone diseases

...looking at the expression of RANKL and OPG in bone marrow stromal cells, osteoblasts and T cells, but nobody had looked in blood vessels," Collin-Osdoby said. "There is a growing appreciation that blood vessels do much more in the body than simply provide a physical barrier and a route to passively deliver...

Pulmonary hypertension in newborns linked to nitric oxide production

...atients undergoing high dose chemotherapy for bone marrow transplantation. The complication of hepatic veno-occlusive disease appears to relate to nitric oxide levels and urea cycle function, Summar said. With Dr. Rick Barr, assistant professor of Pediatrics and Anesthesiology, Summar is studying children ...

Homing in on better bone marrow transplants

.... The finding may allow clinicians to improve bone marrow transplantation by injecting only the cells needed to repopulate the bone marrow after chemotherapy. Robert Sackstein (Harvard Medical School, Boston, MA) and colleagues report in t...

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