Tag: "marrow" at biology news

Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)

...ycythemia vera is an acquired disorder of the bone marrow that causes the overproduction of all three blood ... after being diagnosed. However, the abnormal bone marrow cells may begin to grow uncontrollably in some patients leading to blood hyperviscosity. Patient...

Novel therapies show promise against myeloid leukemia

...ancer of the white blood cells, starts in the bone marrow but can spread to the blood, lymph nodes, and othe... Cytogenetic response measures the number of bone marrow cells that contain the Philadelphia chromosome, an abnormality that is unique to CML cells. The few...

Premier international meeting provides latest news and issues in blood disorders

...promyelocytic leukemia, a rapidly progressing bone marrow cancer, which has led to the improved survival of patients. Dr. Wang is the first speaker from Asia to serve as the Ham-Wasserman Lecturer, which honors an individual who has made a significant contribution to the field of hematology. "ASH i...

Origin of multiple myeloma found in rare stem cell

...elopment of multiple myeloma, a cancer of the bone marrow that destroys bone tissue. The research, publishe...at this stem cell gives rise to the malignant bone marrow plasma cells characterized by multiple myeloma. Current treatments target the malignant plasma...

UIC researchers create tissue-engineered joint from stem cells

...d adult mesenchymal stem cells taken from the bone marrow of rats. Bone marrow is the inner, spongy tissue of long bones like the femur and tibia, the leg bones. Under certain co...

Scientists uncover novel role for estrogen in bone marrow

...ing. Platelets are derived from a specialized bone marrow cell called a megakaryocyte. A mature megakaryocyt...w platelet counts, such as those with anemia, bone marrow abnormalities, or undergoing chemotherapy, may benefit from the administration of estradiol and/or a...

Stem cell gene therapy: selecting only the best

...l in human clinical trials of gene therapy in bone marrow transplantation settings. In an accompanying commentary, Arthur Bank from Columbia University College of Physicians and Surgeons discusses the potential of these results in significantly advancing our knowledge and ability to perform human HSC gene t...

Transparent fish provide window on blood formation and marrow transplantation

...The techniques may be helpful in learning how bone marrow transplants reconstitute the immune systems of pat... fluorescent blood cells. "We've been able to do a marrow transplant on fish," said Zon. "We find it particularly exciting that we can now watch how these cel...

Anti-platelet drug blocks bone metastases in mice

...een bone metastases and osteoclasts, cells in bone marrow that normally break down the materials in bone for... group then conducted an experiment involving bone marrow transplants from the genetically engineered mice into normal mice. The transplants protected normal ...

NCI awards $7.6 million to prostate cancer research collaboration

...interactions between prostate cancer cells and the marrow stromal cells that facilitate the progression of metastases in bone and bone marrow. By better understanding the bone stromal "microenvironment," researchers predict a better understanding of how metastasis occurs within the bone, which will lead to...

UCLA study identifies stem cell in artery wall

...cells that change into cartilage, bone, muscle and marrow stromal cells. The new study will be published onl...s (CVC), are the only cells other than actual bone marrow stromal cells that support survival of immature (developing) blood cells. This finding may have futu...

Stowers Institute researchers identify stem cell niche

...issue of Nature . HSCs are a population of bone marrow cells capable of self-renewal and production of al... cells, line the surface of trabecular bone in the marrow cavity, support hematopoietic stem cells, and constitute the primary cellular component of the niche...

Bone marrow fusion with nerve cells may repair damage, Stanford researchers say

STANFORD, Calif. - Bone marrow cells can fuse with specialized brain cells, possi...ng debate: Do adult stem cells transform from bone marrow cells into other cell types, such as brain, muscle or liver cells, or do they fuse with those cells ...

Childhood brain tumors associated with rarely inherited BRCA2 gene mutations

...ed by a severe deficiency of red blood cells, bone marrow failure, and a predisposition to cancer. The registry was established at The Rockefeller University in 1982 to address questions relating to diagnosis, prognosis, treatment, natural history of the disease, and cancer incidence in a large number of pa...

UCSF-led study raises doubts about marrow cell treatment for brain, heart

...e suggested adult stem cells derived from the bone marrow -- a spongy tissue inside bones that makes blood c...n collaboration with the Morrison laboratory, bone marrow cells from one set of mice were grafted into the bone marrow of another set of mice whose own marrow...

National Institutes of Health grant to Rensselaer to further research on healing bone injuries

...se adult stem cells are extracted from banked bone marrow samples and then grown in the Rensselaer biology lab. Kristen Bennett, associate professor of mathematical sciences at Rensselaer, is providing the predictive analysis equations that ultimately will sort out the set of conditions that will cause the ...

Genes discovered that regulate blood stem cell development

...or patients with severe congenital anemias or bone marrow transplantation for cancer," adds Zon. Scientists studied a mutant that had a severe anemia because it had few blood stem cells, and also had a tail defect. The zebrafish mutants generally die within seven to ten days after fertilization. They di...

Stem cells delivered into back of eye hold promise for people with retinitis pigmentosa

...gative stem cells from the bone marrow. Adult bone marrow stem cells are "pluripotent" and have the potentia...eve the same rescue effect in mice with human bone marrow cells, the technique is still some distance from the clinics. At the moment, Friedlander and his col...

Enzyme discovery sheds light on causes of rare disease, cancer

...certain types of cancer. The disease leads to bone marrow failure (aplastic anemia) and is associated with birth defects such as missing or extra thumbs and skeletal abnormalities of the hips, spine or ribs. Many who have FA eventually develop acute myelogenous leukemia and are prone to head and neck, gastr...

OHSU scientists uncover key protein for Fanconi anemia, cancer susceptibility

...he disorder, which can lead to birth defects, bone marrow failure and increased incidence of cancer, including leukemias and solid tumors. In addition, there is a growing appreciation among scientists that the FA pathway is integrated with the breast-ovarian cancer-susceptibility pathway. Scientists estimat...

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