Platelet refrigeration method may ease shortages for transfusions, researchers report in Science
...s, or they may have undergone chemotherapy or bone marrow transplants. Karin Hoffmeister of Brigham and Women's Hospital and Harvard Medical School, and one of the lead authors of the Science study, expects the need for platelets to increase in the future. Thomas Stossel of Brigham and Women's Hospital and......may not necessarily require that donor blood, bone marrow or whole organs are a "match" with the recipient -...tic stem cells (HSCs) are parent cells in the bone marrow that give rise to blood cells. Allogeneic stem cell transplantation has great potential in the treat...Researchers identify genes that may be associated with prognosis in pediatric leukemia
...less than 15 years of age. Samples of either bone marrow or peripheral blood were collected and classified ...er of the blood-forming tissue, primarily the bone marrow and lymph nodes, and is divided into several subtypes. Early symptoms of AML may include fever, chi...Splitting hairs: GATA-3 function in hair follicle development
...iking parallels between how stem cells in the bone marrow and those in the skin undergo differentiation in the body."...Adult mouse bone marrow stem cells can become cells of the nervous system
...sity of Minnesota researchers show that adult bone marrow stem cells can be induced to differentiate into ce...unctional dopamine producing cells from adult bone marrow stem cells needed for therapy of Parkinson's," said lead investigator Catherine Verfaillie, M.D., di...Weizmann Institute scienists find that stem cells in the bone marrow become liver cells
...ting for the maturity call. Stem cells in our bone marrow usually develop into blood cells, replenishing our...s damaged, signaling to the stem cells in the bone marrow to come to the site. The scientists were able to pinpoint the signaling molecules HGF, MMP-9 and S...Grant funds research to develop tissue-engineered solutions for heart disease
...ish populations of stem cells from muscles or bone marrow within a polymer that is specially formulated for flexibility and permeability and that biodegrades at a stable rate into non-toxic components in the body. The plan is to use this polymer scaffold as a bridge to generate new, healthy, native tissue. ...Study results show promise for development of gene therapy to treat blood diseases
...n oncoretrovirus to transfer MGMT into normal bone marrow cells. The treated cells were then transplanted i...ant an adequate number of genetically altered bone marrow cells into humans to result in successful treatment of these diseases," said Dr. Persons. "We belie...Stem-like cells from peripheral blood restore function in rats with severe stroke
...ate the release of stem-like cells from their bone marrow into the bloodstream before a blood sample was col...cells have become an alternative treatment to bone marrow transplants for patients with blood cancers. They are easier to obtain, lead to faster recovery from...Embryonic hope for damaged spines
...ng last week, would be to first give patients bone marrow stem cells from the same source as the nerve cells...sues, including adult stem cells derived from bone marrow and nerve cells from the nose. Human trials of some treatments, such as using nose cells, have alrea...JCI table of contents, July 1 2003
...ibly the repair of other solid organs. TITLE: Bone marrow stem cells contribute to repair of the ischemicall....pdf Specific donor cell selection during bone marrow transplant achieves immune reconstitution without recipient rejection Graft-versus-host disease (GV...Tissue-engineered bone speeds healing in laboratory tests
...o this spongy matrix, the researchers drizzle bone marrow cells, which can differentiate into osteoblasts, the strong, mineral-like cells of mature bone. The marrow cells take up residence in the scaffold and begin growing and multiplying. As they mature, the scaff...New center for preparation and distribution of adult stem cells
...will prepare and distribute a continuous supply of marrow stromal cells (MSCs) derived from adult human and ...s shown that when injected into animals whose bone marrow function has been altered, progeny of the MSCs populate several tissues, including bone, cartilage, ...U of T scientists build a bridge for new bone
...team then implanted the scaffolds-seeded with bone marrow cells-in the damaged femur bones of rabbits. Withi...aining the scaffolds. Within eight weeks, the bone marrow cells had developed into bone throughout the entire volume of the scaffold, which gradually dissolve...JCI table of contents, 16 June 2003
...ecrosis and suggests that approaches aimed at bone marrow stem cell propagation and delivery to the kidney s...sued in efforts to treat this disease. TITLE: Bone marrow stem cells contribute to repair of the ischemically injured renal tubule AUTHOR CONTACT: Lloyd Cantl...NHGRI study may help scientists develop safer methods for gene therapy
...to the LMO2 gene, a gene that is turned on in bone marrow cells to promote the growth of white blood cells. ...y time they do a treatment, something like 70 bone marrow cells will have the new genes integrated close to the LMO2 gene," Burgess said. "That seems to be a...UT Southwestern researchers find immune system stages for eliminating viral infections, cancer cells
...rrently mediocre. Leukemia is a cancer of the bone marrow and blood characterized by the uncontrolled accumulation of blood cells. "Our ability to regulate the function of these cells could allow us to manipulate the immune system in new ways to combat infections and cancer," Dr. Schatzle said. "Our discov...University Health Network researchers discover new class of human stem cells
...cells that rapidly grow when implanted in the bone marrow of mice. The findings, available today in an advance on-line publication of the international scientific journal Nature Medicine, are a major advancement in human stem cell research with possible significant clinical implications for designing more e...Faster method for growing adult stem cells for bone regeneration developed at Hebrew University
...in utilizing adult stem cells, taken from the bone marrow of the patient being treated, without having to develop them further in a culture outside the body prior to transplantation. This enables faster and more effective treatment to be given to those suffering bone injuries. Aslan's work is now being fur...Abnormal immune response may play major role in glaucoma, study says
... the inflammation-causing immune cells in the bone marrow with normal donor cells restored the eye's "immune... tested their theory further by replacing the bone marrow of mice destined to develop pigment dispersion glaucoma with bone marrow from normal mice. They foun...