'Kissing' RNA and HIV-1: Unraveling the details
...ed into new virus particles, which undergo further maturation after release from the infected cell. CARB scientists found that specific sites in the "kissing" structure acquire a proton (a positively charged particle) at a pH close to that of living cells. The proton's presence alters the RNA structure and acce...JCI table of contents, February 2, 2004
...t it is the pathways of T cell differentiation and maturation in reaction to these epitopes in T1DM patients (in whom autoimmunity develops) and normal individuals (in whom autoimmunity is arrested) that are different. Upon exposure to antigen, nave T cells in normal individuals differentiate into T cells that ...Scientists' findings may lead to better understanding of how that sleep develops, matures
...tnatal months and sleep homeostasis goes through a maturation period. Theta activity and not delta activity seems to reflect the dissipation of sleep propensity during infancy and the nocturnal pattern of specific EEG markers may reflect their different functional roles in the sleep process during infancy....JCI table of contents, 16 February 2004
...arrow. Proteins such as K-ras are critical for the maturation of these cells, and oncogenic mutations in K-ras are present in up to 15% of AML patients. In order to better characterize the biological consequences of expressing oncogenic K-ras in immature bone marrow cells, D. Gary Gilliland and colleagues from ...Mouth microbes may help shape immune system, says Stanford research team
... the functions they perform, such as immune system maturation and defense against pathogens." Relman will present an overview of his lab's work on this subject, along with some new findings Feb. 16 as part of the "Innate Immunity and Oral Health" program at the annual meeting of the American Association for the...HIV exhausts the immune system through chronic non-specific activation
...al to the host, this causes non-specific premature maturation of many of the remaining functional T-cells. The resulting premature aging and exhaustion of the immune system increase the likelihood of opportunistic infection. HIV targets white blood cells with surface receptors called CD4. These CD4, or helper, ...JCI table of contents, March 1 2004
... of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion AUTHOR CONTACT: Noemi Sevilla Universidad Autnoma de Madrid, Madrid, Spain. Phone: 34-91-397-8477 Fax: 34-91-397-4799 E-mail: nsevilla@cbm.uam.eds View the PDF of this article at: https://www.the-jci.org/p...UIC researchers discover gene that causes liver cancer in animals
...life cycle of a cell, including its proliferation, maturation and death. In the current study, scientists in Costa's lab used genetically altered mice to establish the link between Foxm1b and liver cancer, showing that the gene is essential for the cancerous cells to multiply. "Foxm1b is expressed in many diff...Introduction of the 'Rett protein' in post-mitotic neurons rescues Rett Syndrome in mice
... The timing of MeCP2 activation coincides with the maturation of the central nervous system and recent reports suggest that MeCP2 may be involved in the formation of contacts between nerve cells and may function in activity-dependent gene expression (i.e. learning). Multiple labs have shown that selective muta...NASA-inspired technology may help preserve women's future fertility after cancer treatment
...to evaluate resulting changes in egg structure and maturation using the different mediums and culture systems. "Our goal is to understand which features of the artificial environment contribute significantly to egg cell changes," said Dr. Russell. At the end of the 72-hour culture period, follicles were evaluat...PTC Therapeutics' researchers identify biochemical pathway important for modulating cell growth
... for a novel biochemical pathway that controls the maturation of both tRNA and mRNA. Inhibitors that target the RNA processing events carried out by this enzyme complex create new opportunities for therapeutic intervention. PTC has filed worldwide patent applications to secure its ownership rights in all aspe...Dampened hopes for transplanting bone marrow stem cells in heart attacks
...ts believed they were looking at cells produced by maturation of blood stem cells, whereas in actual fact they were seeing a tiny number of fused cells. Now it is time for second thoughts, and these might affect the many large-scale patient trials that were initiated during the hopeful period. In Sweden there...Imaging study shows brain maturing
...al developmental milestones occur. The sequence of maturation also roughly parallels the evolution of the mammal... maps that, together, form the movie showing brain maturation from ages 5 to 20. It was long believed that a spurt of overproduction of gray matter during the fi...Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
...a certain molecule that serves as a switch for the maturation process. Reporting in a plenary session at the Ame...ascade of immune events that begins with the rapid maturation of dendritic cells. Because of the liver's position downstream from the intestines, dendritic cells...Choice of food helps hungry caterpillar
...tor, but is a necessary chemical in the growth and maturation of many insects including other caterpillars and wasps. "Physiologically, we do not know how the caterpillars manage to survive without it in their diet," says Mescher. "It is a process of specialization and we plan to look at this next...Early dexamethasone exposure has long-term neurodevelopment, neuroendocrine effects
...nsient variations in neurodevelopment and physical maturation when compared to controls. However, no gross neurological deficits were observed in the dexamethasone-treated pups by day P20, suggesting that the pathways relevant to organization of reflexes and behavior assessed on the exam were developing normal......rs typically erupt. "While the age of reproductive maturation may have varied in early human groups, if it were 15, then age 30 would be the age at which one could theoretically first become a grandmother," Caspari noted. Other scientists have argued that the presence of grandmothers confers an important evolu...New database to help develop AIDS drugs
...the HIV protease (see image) that is essential for maturation of HIV. In addition, the database is expected to help scientists understand and circumvent the problem of mutations that make HIV resistant to certain drugs. NIST scientists annotate the structural data with information from various sources and in......Researchers have shown that this final step in egg maturation can be blocked by a chemical called cyclic AMP (cA...otein in the cAMP molecular signaling pathway, egg maturation could be completed in a test tube. The apparently reversible nature of the infertility block caused ......Researchers have shown that this final step in egg maturation can be blocked by a chemical called cyclic AMP (cA...otein in the cAMP molecular signaling pathway, egg maturation could be completed. The reversible nature of the infertility block caused by loss of the Pde3a gene ...