New Finding Suggests "HATs" Are Key To Gene Activation Puzzle
...scription. "These findings suggest a distinct mechanism by which gene activation is occurring: The cell's transcriptionalapparatus has chromatin-unfolding properties," says Mizzen. "This is theclosest we've come yet to understanding how genes are activated through chromatin unfolding, and I expect that wi...Molecular Imposter Rebuts Long
...rs that the shape of the DNA bases may be thechief mechanism by which DNA-replicating enzymes selectthe right bases to insert into a growing strand," Kool says. "Theenzyme might form a tight pocket around the DNAtemplate which allows only correctly shaped bases to be added" --like an empty space in a jigsaw pu...Fund Aims To Repay Developing Nations For Valuable Genes
...ed facultyresearchers with a practical, if modest, mechanism for exercising socialresponsibility in the global community. UC Davis Chancellor Larry Vanderhoef, a plant biochemist, is enthusiasticabout the new fund. "Establishing this fund is, simply put, the right thing to do. Hopefully,it will serve as a mo...New Study Shows Steps Leading To Colon Cancer
...man cells elsewhere has identified a key signaling mechanism required for normal embryonic development. When inappropriately activated, studies show, the mechanism turns healthy cells first into abnormal ones and then often into tumors. "Our work, together with ...Researchers Find Production Point Of Key Protein In Fragile X Syndrome
CHAMPAIGN, Ill. - Efforts to understand the mechanism for the most commoncause of genetically inherited ...not beenknown," he said. "This finding points to a mechanism of actionof the protein that may account for the mental retardation." Greenough's team studied rats......signment to the students last fall. The power tool mechanism was among 10 inventionsconstructed by Hopkins seni...nd institutional sponsors. Creating the power-tool mechanism had special significance forHumphries, who lost his legs in a 1991 land mine explosion whileserving ...Duke researchers find existing drugs can stop fungus that attacks AIDS patients
...wo leadinganti-organ rejection drugs, both jam the mechanism that activates immunesystem cells by blocking a single target inside cells, a protein calledcalcineurin. Since the drugs only work at body temperature, calcineurin must be requiredfor cells to grow at this temperature, Heitman said. To test the...Scientists Bridge Gap In Cell Communication
...iseases like some cancers. "We've found a mechanism that is really important," said Sean Carroll, a co-author of the study and a molecular biologist at the Howard Hughes Medical Institute at UW-Madison. "The universe of genes regulated by this pathway is very large. I would guess hundreds of genes." ...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...first time found direct evidence of a potential mechanism of a monkey virus in the development of mesothe...ano’s team’s discovery of a potential mechanism for some cases of disease development strengthens the argument for the virus. "Although ......ogical hallmark that suggests that a singledisease mechanism may underlie this group of afflictions." The new results suggest several directions for future research,according to Pittman. Because the proteins involved are produced in cellsthroughout the body, including the brain, one question scientists...Where Fossils Fear To Tread: Scientists Follow Genes To An Ancient Ancestor
...st once a very long time ago, and that the genetic mechanism is still at work. "Everybody thought the ...l Academy of Sciences. "We found the same mechanism in all of these divisions of the animal kingdom. The architecture can vary tremendously, but the gen...Altered Genes, Altered Metabolism--Longer Life?
...ich have anextended lifespan, suggesting that this mechanism in humans may have thepotential for slowing down aging. The National Institute on Aging, one of the 18 Institutes which make up theNational Institutes of Health, leads the Federal effort supporting basic,clinical, epidemiological and social research ...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...y laboratories indicates that the clock orcounting mechanism relies on specialized bits of DNA, called telomeres, at theends of each human chromosome. In the absence of telomerase enzyme, thesespecialized end-structures grow shorter with each round of cell division. Eventually, the shortening process reaches ...No Link Seen Between Breast Cancer And Pesticides, PCB Exposure For General Population
...ncluding breast tissue," Moysich said. "The chief mechanism for eliminating them from breast tissue is lactation, which flushes them from the system." She said that even though the baby is exposed to these substances, the beneficial effects of breast feeding appear to outweigh potential risks associated with...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
...es in colorectal cancer and understanding their mechanism in carcinogenesis is crucial to the development...ugh a "cell cycle." Cells have an innate repair mechanism to fix the problem; both p53 and MSH2 are involved in regulating this cycle as well as control...Maternal Lead Exposure Linked To High Numbers Of Cavities
...reduced saliva flow has beenimplicated as a likely mechanism of decay in lead-inducedcavities. "Lead is not something that most dentists think of when theytalk about the causes of cavities, but they should," says Watson.Poor hygiene, lack of dental care, and poor diet are still majorconcerns of dentists, ...New Mechanism To Explain Carbon Monoxide Poisoning Identified
... Medical Center have discovered anovel biochemical mechanism for carbon monoxide (CO) poisoning that may someda...focate and die. "This traditional viewexplains the mechanism of carbon-monoxide toxicity in only a small fraction ofall people exposed to it," says senior author...Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer
...und direct evidence of a potential monkey virus mechanism behind the development of mesothelioma, a rare ...ficant, Giordano said, because of the different mechanism potentially involved in causing cancer. In the case of mesothelioma, the body’s tissue level...Long-Time NIH Grantee Wins Nobel Prize In Chemistry
...r for a lifetime spent investigating the molecular mechanism by which ATP--the cellular energy that drives all biological reactions--is formed," said Dr. Marvin Cassman, NIGMS Director. "Determining how ATP is synthesized has been a central problem in biology for decad......the animal," she said. "If we can find a delivery mechanism to get the right concentration of IGF-I to the site of injury, we may be able to regenerate nerves or prevent them from dying." Research funding for the U-M study was provided by the National Institutes of Health , the American Diabetes Association...