Obscure Enzyme May Play Major Role In Heart Disease
...her risk. The present studyhelps us understand the mechanism behind that relationship. In experiments ... Aviram has worked for the past decade on the mechanism by which bloodcholesterol quantity (cholesterol levels), as well as blood cholesterol quality(choles......ctive in killing human cancer cells invitro with a mechanism of action similar to that of the clinical anti-canceragent Taxol . Under terms of the license agreement, Harbor Branch grants Novartis exclusive,world-wide rights for the development, use, manufacture and sale of discodermolide for all potential the...Stanford Microbiologist Receives Lifetime Achievement Award
...t of this set of genes. He discovered a regulatory mechanism for controlling gene expression byattenuation, a device which determines whether transcription, once initiated,produces translatable messanger ribonucleic acids or is terminated beforereaching the structural genes. He was nominated by Rober...Researchers Identify Protein Critical To Urine Concentration
...ntal information about how the urine concentrating mechanism works in the kidney. It also has potential clinical implications for the treatment of diseases associated with fluid retention, or refractory edema, including congestive heart failure and cirrhosis, said the researchers. "If we could inhibit the wa......formation in certainsubpopulations. -- The mechanism of urinary bladder tumor formation in male rats as itrelates to other test species and to humans. Final comment was also requested for additional substances to be listedas "reasonably anticipated to be a human carcinogen": -- Chlor......pparent naturalimmune response, but on a molecular mechanism that enhances it. "This line of research holds some promise," said Levy, UCSF professor ofmedicine and director of the Tumor and AIDS Virus Research Laboratory. "Ibelieve the present approach to controlling HIV is doomed to fail. There is norestora...Antioxidants May Reduce Harmful Complications Of Diabetes
... withoutmicroalbuminuria. Though the exact mechanism of action of the oxygen free radicals is notyet clear, these findings confirm in humans earlier animal studies of thechemicals' role in damage in diabetes, Opara said. Previous Duke studies byOpara have shown that vitamin E can delay the development...Aspirin's Preventive Action In Heart Attacks Tied To Genetics
...eople from developing heart attackshave traced the mechanism back to a specific genetic factor present on thesurface of clotting cells called platelets. The discovery could be used to determine which people at risk for heart attacksand heart disease might benefit mostly from daily doses ofaspirin and which peo......ecton structural plasticity might provide a common mechanism for thedisadvantageous effects of apoE4 in Alzheimer's disease, Parkinson's disease andrecovery from bypass surgery and cerebral hemorrhage." The researchers will explore this idea further. The apoE3 and apoE4 micealso will be invaluable for...High-Altitude Cerebral Edema Likely Caused By Leaks In Blood-Brain Barrier
...he intracellular spaces, he said. Yet another mechanism that may be at work involves elevated levels of leukocytes that may cling to the lining of cerebral blood vessels and cause leaks in the blood-brain barrier. Krasney and colleagues are attempting to clarify further the importance of these mechan...The First Rejection: Eggs Sequester Bits Of Sperm For Later Elimination
...tochondrial derivatives to the midgut as an active mechanism to avoid the inheritance of the father's mitochond...where it will be eliminated is much easier." This mechanism works no matter how long the sperm's tail (and therefore the amount of mitochondrial derivative that...Birds Sing The 'Story Of Their Lives,' Theorize Duke Biologists
...that this overlap is really quite good,revealing a mechanism by which song quality could be used by females to assessquality of males." For example, the researchers cited studies showing male birds withsuperior resistance to disease or parasites withstood insults better and coulddevote a larger proport...HIV Discriminates Amongst Cells
...ontracting actinin the target cell could also be a mechanism that prevents HIV from enteringinactive cells, or cells in the early stages of cell death. We know that theseare poor host cells for viral replication, and they don't have an active actinfilament network to pull surface molecules together," Dr. Schw...... plasticity in the brain. As interference with the mechanism underlying the improvement of brain f...erience. The knowledge of a molecular mechanism being specific for the improvement of brain function might be useful for the developmen...Biochemists Gain Crystal-Clear Insight into 'Ancient' Enzyme
...cting the pre-tRNA. This is reallya very different mechanism for what these proteins do," said Fierke. The Duke researchers performed chemical experiments that confirmed thiscontact, producing altered versions of the protein that would chemicallycross-link with the RNA in the cleft, allowing them to unequivoc......starch biosynthesis. The biochemical mechanism by which the R1 protein phosphorylates amylopectin remains to be elucidated. It is not known which substrate acts as a phosphoryl donor, nor which type of glucans are phosphate acceptors. Evidence that phosphoenolpyruvate ma......ncer. The orally active drug acts through a unique mechanism to induceselective apoptosis, or programmed cell death, in precancerous and cancerouscells without affecting normal cells. Cell Pathways Inc. has begun or plans to initiate clinical trials of FGN-1 in1998 in seven clinical indications. The company is...Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimer's Disease
...L-evoked cell deathdid not occur, showing that the mechanism through which ADDLs exert theirtoxicity is blocked by removal of Fyn. Furthermore, blocking ADDL binding sitesalso afforded neurons protection against the toxic effects of ADDLs. Finch said the group's results are significant because: "Dogma...Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells
...ight be happening. If we can better understand the mechanism involved, wemay be able to find other ways to effectively block angiogenesis. However, weneed to keep in mind that these results will have to be validated in an in vivotumor model to fully understand the significance of these findings." Chris William...Colorado State Research Indicates Two TB Vaccines Show Promise
...d be looking upon these new vaccines as a boosting mechanism and not merely as a replacement for BCG." A major breakthrough of both vaccines tested at Colorado State is that, unlike the BCG vaccine, they don't trigger a positive reaction to the skin test commonly used to determine if an individual actually ha...