Tag: "mediates" at biology news

The MAP kinase pathway in coxsackievirus infections

...ction in vitro, including the kinase p56Lck, which mediates signals from the T cell receptor, and the Erk kinases, which act downstream of p56Lck in T cells and activate the MAP kinase pathway in many cell types. Drugs and genetic lesions that block this signaling pathway prevent viral replication in cultured...

The genetics behind hair loss

...to complete hair loss. The discovery that Hairless mediates thyroid hormone receptor-dependent gene repression provides the first molecular insight into the role of Hairless in congenital hair loss disorders. This discovery represents a stepping stone upon which researchers can further delineate the genetic p...

Integrins and signaling in psoriasis

...The authors focus on the MAP kinase pathway, which mediates integrin effects on basal cell growth. They show here that they can bypass a requirement for high integrin levels by using a constitutively active version of the regulatory MAP kinase kinase MEK to maintain high MAP kinase activity in suprabasal cell...

The protective role of secreted CD14

... surface-bound form for LPS binding and apparently mediates the transfer of LPS to HDL. Increasing sCD14 should therefore drive LPS from the cell surface to a biologically inactive form. Interestingly, sera from individuals suffering trauma and sepsis accumulate high levels of sCD14. To test the possibility ...

Wistar scientists add difficult-to-sequence stretches to human genome data

...cer." In addition to cell division, telomeric DNA mediates many important biological activities, such as cellular aging, movement and localization of chromosomes within the nucleus, and transcriptional regulation of subtelomeric genes. To analyze the telomeric regions, the researchers developed a specialize...

Fighting Fungi

...iscovered that the unfolded protein response (UPR) mediates this morphological response. The UPR is a cellular...duced, and therefore the UPR active. Thus, the UPR mediates the environmental regulation of pathogenicity. The discovery that the UPR represses filament formati...

Mammalian telomere maintenance

... Hsu and colleagues have found that the protein Ku mediates mammalian telomere capping. Telomere capping conceals and disguises the ends of chromosomal DNA so to distinguish it from double stranded DNA breaks. Telomere capping thereby prevents the fusion of chromosome ends, an event associated with geneti...

Californian wins neuroscience prize endowed by UNC scientist

...ne. Julius discovered the nerve cell molecule that mediates responses to capsaicin, the active ingredient in h...arkably, it then turned out that the receptor also mediates responses to noxious heat." Moreover, the only neurons in the entire nervous system that express th...

UPenn protein study

...cientists have long understood that the Gz protein mediates the work and effectiveness of cell receptors, influencing the way the cells experience and interact with their environment. But until the Penn study, they had notestablished what, exactly, that influence might be. The Penn investigation was initiated...

New link uncovered in nerve cell mechanism thought to power learning and memory

...d we wanted to learn more about the mechanism that mediates this trafficking of AMPA receptors within dendrites." The new study provides these answers. Malinow and his colleagues took advantage of the fact that most of the neurons they study contain AMPA receptors with both "GluR1" and "GluR2" subunits. Rec...

UCSF team identifies gene crucial to blood pressure regulation

... heart, brain, and arteries. The gene, called sgk, mediates the effects of aldosterone, a key hormone forregul...ene had not beenmade. "Now that we know that sgk mediates aldosterone's effects, we can begin todevise ways of blocking its action. This holds the promise of...

Scientists Discover Important Molecular Link That Allows Cells To Form Blood Vessels

...helial receptor called EphB1and the machinery that mediates cell attachment, integrin alpha 5 beta 3, whichhad earlier been implicated in angiogenesis. These Vanderbilt researchers proposed in an earlier report in the journal Genesand Development that EphB1 is an important, if not dominant, player inendotheli...

Scientists Discover Function For Type III TGF-Beta Receptor

... A complex ofType I and Type II TGF-beta receptors mediates the well-characterized effects ofthe growth factor TGF-beta on cell growth and differentiation. The Type IIITGF-beta receptor is not capable of sending a signal into the cell by itself andwas considered to be a facilitator of the Type I/II complex. "...

Better Binding Through Chemistry

...n molecular subunit known as an "SH2 domain,"which mediates protein-protein interactions that cause some diseases. Thisdomain is regarded as a choice target for drug development because it is foundin tyrosine kinases, enzymes that are critical components of the molecularmachinery involved in cancer, osteoporo...

Scientists Show For The First Time How Leprosy Bug Targets Peripheral Nerves

...s via molecular hooks called laminin receptors and mediates cellularcommunications from the environment outside the cell to the Schwann. A moleculecalled dystroglycan, a component of a protein assembly called thedystrophin-glycoprotein complex, is one of the major laminin receptors of theSchwann cell. Dystrog...

Move Over, Protein Kinase C, You've Got Company: Munc13-1 Is A Novel Diacylglycerol Target That Modulates Neurotransmitter Release

...h the cell membrane. The protein machinery that mediates this release process is subject to regulation by numerous factors. Regulation occurs either directly, e.g. through proteins that interact with the release machinery, or indirectly, e.g. through second messengers that activate protein kina...

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(Date:4/24/2014)... from The University of Manchester have identified a way ... more open to treatment. , The study published today ... for the development of drugs to target cells that ... made the discovery whilst exploring the possible mechanisms behind ... treat breast and colon cancer. , Dr Andrew Gilmore, ...
(Date:4/24/2014)... with an antimicrobial peptide could help to lower the risk ... Optometry and Vision Science , official journal of the ... published by Lippincott Williams & Wilkins , a part ... and now humans support the biocompatibility and safety of lenses ... research by Debarun Dutta, B.Optom, of The University of New ...
(Date:4/24/2014)... new Institute for Biomedical Sciences at Georgia State ... grant to develop novel therapeutics against Respiratory Syncytial ... Eunice Kennedy Shriver National Institute Of Child Health ... Health will support Plemper,s drug development goals of ... distinct alternative compound. , Infections by RSV, a ...
(Date:4/24/2014)... than one out of three survivors of critical ... The Lancet Respiratory Medicine , and the ... than mentally. , It is one of the ... functional outcomes of critical care survivors, according to ... Medicine, and it highlights a significant public health ...
(Date:4/24/2014)... has found a relationship between motor skill deficiencies and ... in very young children. , The findings, believed ... relationship between motor skills and autism severity, indicate that ... included in treatment plans for young children with autism, ... of Public Health and Human Sciences. , "Recognizing ...
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