Bacterial Toxin Surprises Scientists
...ess this strategy in the potent antifungal medications amphotericin and nystatin. Yet until recently, researchers have known little about how such membrane-piercing proteins work. Now, using an innovative technique, NIH-funded researchers at New York City's Albert Einste...Florida Researchers Discover Gene For Fatal Childhood Disease
...ne's role in the spread of cancercould lead to new medications or treatments for all cancer patients, he said. Meanwhile, researchers discovered that mice with Chediak-Higashisyndrome are protected against some forms of autoimmune disease, especiallythe complications many lupus patients develop. "Thi...Biosensor Is A Model For Widespread Testing Of Chemicals, Molecules
...ng particular disordersand in precisely regulating medications used during cancer chemotherapyor other complexes diseases. The study was funded by the Whitaker Foundation, which awarded Hellingaa three-year Whitaker Fellow grant. Hellinga is an assistant professor ofbiochemistry at the medical center. Wor...Huntington's Disease Findings Pave Way For Potential Cure
...sease Initiative will support furtherresearch into medications effective in treating HD....Imaging Studies Illuminate Brain's Response To Cocaine
...rain areas thatmight be targeted in developing new medications to either block individualaspects of cocaine's effects - like the rush versus the craving experience - oras broader treatments for cocaine abuse and addiction." Additional funding forthis study was provided by the National Heart, Lung, and Blood Inst...First Selenium-Based Orally-Active Antihypertensive May Lead To New Family Of Therapeutic Agents
...lenium and the availabilityof other blood pressure medications halted further development untilrecent reports highlighting selenium's potential importance promptedrenewed interest. "There are many kinds of antihypertensives on the market that act indifferent ways," May said. "We don't believe these compounds h...Study Reviews Medication Use In Elderly Cardiac Patients After Discharge
...lot of questions and have aroutine for taking your medications so you know you are on a proper schedule.There are...nd that urban residents receivedsignificantly more medications and had more changes in their drug regimenthroughout the five-month study period than their rural co...UMass Researchers Announce Birth Of Genetically Modified Cloned Calves
...tities of therapeutic human proteins, essentially, medications for people in their milk. These proteins can either be extracted and purified, then taken in the form of a pill or injection, or drunk like a conventional glass of milk. This new field, a combination of pharmaceuticals and farming, is called "pharmi...Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients Taking Warfarin
...riety of questions regardingtheir health, diet and medications taken in the weeks before their blood test. The researchers found several factors associated with an increased risk of anINR greater than 6, the most important of which was ingestion of acetaminophen. Patients who took the equivalent of at least fo...Peptides Implicated In Body's Response To Pain
...sing need for more compounds in thearsenal of pain medications available to physicians and patients. This studyputs us one step closer to correcting this very serious problem." Certain chemicals, glutamate, for example, act in the transmission of painmessages by stimulating pain receptors. It has been previou...Needlestick Injuries Common In Female Veterinarians, Study Finds
...s for doing the study was the fact that someof the medications and exposures veterinarians might experience would bethe same as health care workers who work with people, in terms of anestheticgases, some of the drugs and X-rays,” said Jay Wilkins, co-author ofthe study and associate professor of public heal...Dietary Determinants Of Iron Stores In A Free-Living Elderly Population: The Framingham Heart Study
...ergy intake, smoking, and use of aspirin and other medications known to affect blood loss, we found five significant dietary factors associated with iron stores. Heme iron, supplemental iron, dietary vitamin C, and alcohol were positively associated with serum ferritin, whereas coffee intake had a negative assoc...Taking The "Ouch" Out Of Needles: Arrays Of "Microneedles" Offer New Technique For Drug Delivery
...able to administer small quantities ofhigh-potency medications throughthe skin without causing pain. Arrays of the microneedles could improve administration of existingmedications, allow development of new therapeutic compounds and open the doorfor microprocessor-based systems fordelivering drugs continuously o...Gene Variant Found That Can Help Protect Against Nicotine Addiction
...on gives anew target for developing more effective medications to help people stopsmoking." Researchers found three different gene types (alleles) for the enzymeCYP2A6, including a normal, or wild-type allele that is fully functional, andtwo null or inactive alleles. People with the null alleles functi...Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
...en is estimated to exceed $500 million per year.No medications treat the latent life-cycle stages of the T. gond... of malaria, we were pleased to findthat combining medications in a logical way, to inhibit multiple enzymes in thepathway, enhanced their effect," said McLeod. "T...Researchers Document Transmission Of Protease-Resistant HIV
...harm than good if we don't help patientstake their medications correctly," said Margaret Chesney, PhD, professor ofmedicine at UCSF, a co-investigator of the study, and an expert on adherenceissues. "The bottom line is that helping patients stick to these difficultregimens is as important as the drugs themselve...Wake Forest Study: Dermatologists Provide Better, Cheaper Care For Fungal Skin Disease
...ogists to prescribe less-effective yet more costly medications forathlete's foot and other fungal skin disease. The study has implications not only for the public, but for healthmaintenance organizations that typically limit access to specialists in thebelief that it reduces costs. The results of...... Most of the individuals who had not received the medications were noteven aware of them, the researchers found. There were no significantdifferences among men and women or among blacks and whites as to who was morelikely to receive the medications. The in-depth interviews revealed that the most common...Depression A Risk Factor For Coronary Artery Disease In Men
...on,with 33 percent reporting use of antidepressant medications and 44 percentreporting psychotherapy with or without use of benzodiazepines or othersedatives. Treatment for depression did not necessarily lower the men's risk ofdeveloping CAD, Ford says, but those who were treated may have been moreseverely depr...CU Team Develops New Techniques For Repair Of Bone And Cartilage
... a bar of soap -- canbe engineered to time-release medications and human-growth factors to aid in thehealing process, said Anseth, the project director. The new bone-healing process, patented by Anseth several years agothrough CU and licensed by a major Midwest biotechnology company, has shownpromise in...