New technique will improve delivery of drugs and gene therapy for cystic fibrosis patients
...pies for patients with CF that involve aerosolized medications (e.g., antibiotics) and newer therapies that are under development (e.g., gene-carrying vectors) are very expensive to produce. It is important to deliver as much of the drug to the lungs as possible to reduce the cost. Laube says the results from ...Moderate alcohol consumption increases bone mineral density in elderly women
...king history, past use of estrogen, present use of medications or a history of fractures was adjusted in statistical analysis. Dual X-ray absorptiometry was used to measure BMD at the hip, lumbar spine, whole body, and forearm skeletal sites. Blood levels of several bone marker chemicals and the parathyroid horm...Procter & Gamble donates proprietary "super aspirin" technology to Vanderbilt University
...echnology shows promise in improving the safety of medications commonly taken for pain, inflammation, and fever reduction. Along with the patents, P&G is donating all associated intellectual property. As the sole new owners of the technology, Vanderbilt will benefit from all future revenues after the technolo...UF scientists discover novel mechanism underlying bone destruction
... osteoclasts may provide a novel target for future medications to block the bone erosion associated with osteopor...liday said. Biphosphonates are the most common medications prescribed to treat osteoporosis and Paget's disease, in which the excessive breakdown and formation...Gel may cut doses for some medications
...ivery system that might replace some multiple-dose medications with a single daily formulation. Kos Pharmaceutica...e gels would swell rapidly in the stomach, causing medications to move more slowly from the stomach to the intestines. Because the medications would remain in the...Simpler HIV drug regimen may improve results, Science study on monkeys suggests
...hat people with HIV should never stop taking their medications except on the advice of a physician. "More research is necessary to learn how these findings could work in a clinical setting," said lead author Franco Lori of the Research Institute for Genetic and Human Therapy in Washington, DC. But, he added, "O...First gene therapy to calm pigs' out-of-sync hearts
... control animals. Commonly prescribed beta-blocker medications can bring a similar overall result, the researchers say. "But, we believe the gene therapy that ultimately would help humans would, unlike beta blockers, be a long-term solution. Also, because gene therapy is localized to a specific place in the he...New MRI technology provides detailed views of brain development, response to injury
...y during an acute stroke. Researchers testing new medications to prevent brain damage that results from stroke can also use DT-MRI to assess the efficacy of the treatment. With DT-MRI it is also possible to assess damage to the fibers that connect the stroke area to regions of the brain that are distant from i...Researchers question drug for chronic fatigue syndrome
... with recurrent fainting due to NMH. "One of these medications may prove more effective than fludrocortisone in treating NMH among those with CFS," says Rowe. "Over 60 percent of the patients we screened for this study had abnormal heart rate and blood pressure responses during tilt testing, and most had worse s...Physicians present most comprehensive clinical review of St. John's wort for treating depression
...ed for caution, especially for patients on certain medications including tetracycline, cyclosporin, protease inhi...bitors, digoxin, warfarin, some oral birth control medications and those used for asthma. He says there is some evidence that St. John's wort may induce certain en...Diet aid works best with other life changes
...of Pennsylvania and the studys lead author. These medications may decrease the desire to eat by reducing hunger ... and plan meals and snacks in advance. Weight loss medications are not a substitute for an individuals own efforts to improve eating and activity habits. A third g......ese projects are leading to the development of new medications and new strategies for immunotherapy, as well as the identification of hereditary factors related to leukemia. "This grant opens further opportunities for doctors to enhance their skills as scientists," said Dr. Lawrence Loeb, the director of the...Like grapefruit, sour oranges boost drug effectiveness, scientists find, and also why
...own that certain drugs -- including commonly taken medications for lowering cholesterol and blood pressure -- become much more effective when people who take them also drink a glass of grapefruit juice at the same time. That power of grapefruit juice can be beneficial, but also can be harmful in some situations.......ase, hypertension, diabetes and the use of certain medications such as antidepressants. Working with tissue taken from men undergoing penile prosthetic implantation, Christianson and his colleagues verified for the first time that arginase is present in the human penis. The group also found that administering B...Hopkins researchers find tourette drug has unexpected effect
... treatments in the future," Singer says. "Testing medications in a rigorous setting represents the first step in...ct in reducing tics may be less potent than other medications in this category. Tier-2 medications have a greater effectiveness in suppressing tics but have a la......make recommendations for changes in how to use the medications more safely. "Patients taking the drugs listed on the web site should not become concerned and stop taking their medications, as the risk of TdP for most of these drugs is very small," he said. Woosley cautioned, however, that if patients develop s...Talking device keeps HIV patients on the straight and narrow
...ents burdened with a complex schedule of anti-AIDS medications when to take pills and what side effects to watch ...lem in a disease where patients may take dozens of medications a week, the researchers say. The pocket-size device which Hopkins researchers call...MGH researchers shed new light on how pain killers work
... for developing safer, more effective pain-killing medications and delivery systems. NSAIDs reduce inflammatory pain by blocking the action of certain enzymes called cyclooxygenase (Cox) 1 and 2. Cox-1 is normally expressed in the stomach, where it protects against acid damage, and in platelets, where...Novel compound inhibits HIV replication in cell cultures, suggesting possible new type of AIDS drug
... HIV infection commonly rebounds when current AIDS medications are interrupted. A research team led by pediatric immunologists at The Childrens Hospital of Philadelphia announced its results in the March 27 Proceedings of the National Academy of Sciences. The research, by Steven D. Douglas, M.D., Jian-Ping Lai, ...Hormone the trigger for fat metabolism; scientists closer to tests in humans
... have difficulty controlling their weight and many medications commonly used to treat epilepsy and various forms of depression often lead to unwanted weight gain. We hope that this finding will be useful for weight control in these conditions as well." Dr. Patterson said that this new understanding of weight...