Tag: "membrane" at biology news

Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant

... one ofthese proteins, the integrity of the muscle membrane is compromised - eventuallyresulting in muscle weakness that can range from a very mild form to a moresevere, rapidly-progressing type. Building on prior work (much of which has been done at Penn's Institute forHuman Gene Therapy) that has shown th...

Yeast Provides Evidence For Continuous Membrane Theory

...sfor export to the cell surface. According to the membrane outgrowth theory,Golgi cisternae are transient structures, with new cisternae constantly beinggenerated at tER sites. Glick realized he had a unique opportunity to test this hypothesis whenhe noticed very different-looking Golgi formations ...

Alzheimer's Disease And Developmental Biology Linked Through Single Molecule

...or protein with segments inside the cell and inthe membrane at the surface of the cell. When cells commit to become one oranother cell type, they present molecules that bind to the Notch receptor onneighboring cells to communicate this fact, so that the neighboring cell canchoose an alternate path. A...

Plants Use 'Snorkels' To Survive Floods

... ethylene and the receptor of this gas on the cell membrane play a role in its doing so. Various hormones evidently give the alarm to various parts of the plant so that the cells can react by accelerating their longitudinal growth and producing the life-saving shoots. Differences in the capacity to adapt t...

Researchers Identify Molecule That May Be Key In Pheromone Processing

...O.Similarly, pheromone receptors (molecules on the membrane of a cell thatinitially receive a chemical signal) recently identified by Dulac are notchemically related to the odor receptors found in the MOE. With this evidence ofdifferent mechanisms for the detection of odors and pheromones, interest indiscover...

Researchers Track Path Of Safer Gene Delivery Method

...thods using liposomes, which can fusewith the cell membrane to gain entry, have been used in clinical trials to treatCystic Fibrosis and several forms of cancer. "The results that we're gettingwith the polymer rival if not exceed the results achievable with liposomes,"Godbey said. Said Mikos, "One of ...

Discovery Of Mechanism Causing Colon Cancer

...lecules - those molecules that sit in the cellular membrane and allow cells to stick together. In its other role, beta-catenin is known to regulate the performance of genes in the nucleus. However, how exactly beta-catenin does this - and which genes it controls - remained unclear. The second molecular myster...

'Dual Control' Strategy Assures Accurate Cellular Marching Orders, But A Pathogenic Microbe Can Hijack The System

...he Enabled protein links to receptorsnear the cell membrane when it receives an external signal to move. Then ...d's attraction to both thereceptor protein and the membrane phospholipids -- could greatly increase thereliability of the marching orders, the researchers sugge...

New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses

...re the same size as natural cells, but their outer membrane is much tougherthan the phospholipid membrane of biological cells. And, they have the capacityto be undetectable by the human immune system so cou...

Scientists Determine Atomic Structure Of Lego-Like Molecule That Self-Assembles Into Cell's Cargo Capsule

...tor protruding from theouter surface of the cell's membrane and specialized to accept only one kind ofmolecule...the cell, eventually plucking achunk of the cell's membrane inside, along with the receptor and its vitalcargo. All this material becomes enveloped as the clath...

Under the hood of a cellular transport machine

...smitters are constantly released intosynapses, the membrane used to export the neurotransmitters is constantly...cell inside, clathrin moleculescombine at the cell membrane to form a clathrin-coated pit on the insidesurface of the outer cell membrane. The pit then rounds...

SFVAMC-UCSF scientists solve a key protein structure

...in the walls of the cell or mitochondria. Although membrane proteins comprise by mass about 15 percent of cell...s of only a very smallfraction. The structures of membrane proteins have proven much harder to solvebecause they are very difficult to crystallize. In fact, t...

New targets for nerve diseases, nerve regrowth: It's all in the handshake

...linkage between the gangliosides in the nerve cell membrane and a secondmolecule in its myelin sheath. That molecule, myelin-associated glycoprotein(MAG), is known to influence nerve cell stability. Mice with the gene for MAGknocked out also suffer a loss of myelin and deteriorating nerves. Schnaar...

Gene that causes familial British dementia may yield clues to Alzheimer's disease

...sare derived from the processing of different cell membrane precursor proteinscoded by genes located on different chromosomes; FBD amyloid is produced bychromosome 13 and AD amyloid is produced by chromosome 21. This study furthersupports the notion that aggregation of amyloid proteins plays an important rol...

NYU scientists discover gene for a dementing brain disease

...recursor protein sticks out through the outer cell membrane and is cut by special enzymes, producing the amyloid fragment. The amyloid beta protein associated with Alzheimer's disease is generated by a similar mechanism; namely, a larger protein called amyloid precursor protein or APP sticks out from cell me...

Mathematics reveals inner workings of potassium pipeline

... ofthe cell, but getting from one side of the cell membrane to the other is likecrossing a large mountain. "T...e result is that potassium does not cross the cell membrane easily, nomatter which direction it has to travel," he added. Moving potassium through the cell mem...

Protein studies reveal sophisticated control of nerve communication

...ptorsnestle in the specific part of the nerve cell membrane where neurons communicatechemically with each other across a tiny gap known as a synapse. They are theprincipal channels through which positively charged calcium ions stream into thenerve cell. The rapid inflow of calcium and outflow of another ion, ...

Report in PNAS on role of nephrin, the kidney filter protein

...n micrograph of a longitudinal section of the slit membrane which shows a zipper-like appearance. To the left...anying images) the location of nephrin at the slit membrane using nephrinspecific antibodies that can be detected by electron microscopes. Thestructural domain...

Scientists visualize key molecular interactions that activate the immune response to foreign proteins

...of proteins in the interfacebetween the artificial membrane and the T cells. The membrane moleculesconsistently formed a shifting bull's-eye pattern during the first hour ofinteraction. The ...

When opposites don't attract: Understanding why may support new biomaterials, Science paper suggests

...show that, frequently, only a small fractionof the membrane area is covered by adhering particles. Why do the remainingbare, oppositely charged surfaces repel particle adhesion? The researchersshowed that in some cases the system prefers instead to separate into a highlyadhesive zone and another, repulsive, z...

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