Scientists discover new candidate drugs for treating HIV infection
...IV's coat protein, preventing its fusion with cell membranes and therebyits ability to enter and infect cells. The study is reported in this Friday's issue of Cell and was led by Dr. Peter S.Kim of the Whitehead Institute for Biomedical Research and the Howard HughesMedical Institute. To identify these compou...Mayo Clinic study implicates fungus as cause of chronic sinusitis
...ffer from chronicsinusitis, an inflammation of the membranes of the nose and sinus cavity. Itsincidence has bee...ls to attackfungi and the eosinophils irritate the membranes in the nose. As long as fungiremain, so will the irritation. "This a potential breakthrough that off...Researcher finds plant toxin that causes fungal suicide
...not all.Some got through, chewed holes in the cell membranes and made them leak. This part of osmotin's mode of action wasn't too surprising, because many otherdisease-fighting compounds act similarly in plants. But osmotin did more thanchew holes in membranes. It also altered the protein-generating machinery ...Stanford scientists use noise to sort proteins
...ped a method for partitioning two-dimensionalfluid membranes called the membrane chip. Borrowing microfabricati..., theresearchers are working on new ways to attach membranes that they hope willallow them to study another important class of molecules, called integratedmembra......tion of an antigen-presenting cell usingartificial membranes on a glass slide. The membranes, which mimicked the surfaceof antigen-presenting cells, contained molecules that were color-coded. This allowed the investigators to interpretthe movements of molecules on the surface of the adjoining T cell during th...... human papilloma viruses (HPV). Because the mucous membranes are protected by an independent immune system, Dr.Ertl suspects they are not adequately protected by systemic vaccines. Consequently, she and her Wistar research team are designing vaccines thattarget the mucosal immune system. To successfully preven...Pre-delivery digital exams may increase in utero bacterial levels
...men who have ruptured fetal membranes when they go throughchildbirth. ...eria may enter the ruptured membranes and cause inflammation of the sacs thatsurround the fetus. These bacteria, su...NYU scientists discover gene for a dementing brain disease
...loid precursor protein or APP sticks out from cell membranes and the amyloid fragment is formed by specific enzymatic degradation of this precursor protein. Due to the similarities between Alzheimer's disease and Familial British Dementia, the NYU School of Medicine group hopes that the discovery may shed ligh...Treatment restores normal heart rhythm in patients
...antiarrythmic medication thatstabilizes electrical membranes by affecting sodium channels. Ibutilide has beenused until now to convert patients from atrial fibillation to a normal heartrhythm without the electrical shock therapy, but it was not always successful.. In the study, 100 patients with atrial fibrill...Biologists work to preserve rainforests endangered plants
...tion of sugars and proteins whichproetect the cell membranes during drying. If the UC and CREW biologists can find a way to utilize and enhance the plant'snatural defenses against drying, it should improve the surviability of the plantsamples they collect. Dunford, who normally conducts plant physiology experi...Details of promising cancer therapy shows for the first time
... Normally, a completed Rasprotein attaches to cell membranes where it signals cells to grow, whenappropriate. The mutation, which causes a single kink in the Ras proteinstructure, leaves it stuck in the "on" position. Out of control growth thenensues, causing cancer. Since the gene's discovery in the early 1......ego-like, into a protective sphere justinside cell membranes and safely transports nutrients, hormones and othe...er, like clathrin, and enclosing vital materiel in membranes forsafe transit. Such controlled transport is essential for supplying nutrients andvitamins to cells...National Laboratory, National Parks And Forests Leaders Seek To Share Resources
...chemical separationtechniques such as novel filter membranes and technologies under developmentthat can sample the air or ground for chemicals. Such environmental monitoringtechnology will be useful to preserve the health of the natural parks andforests. On the second day of the GYCC conference, INEEL researc...New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses
...eutical -- to a specific location in the body. The membranes wouldcontain a chemical tag - much like the polyethylene oxide head - that isrecognized by only certain cells. Once administered to a patient, thepolymersomes would find their way to cells with a specific binding site for thechemical tag. The team ...Researchers Track Path Of Safer Gene Delivery Method
...ey found that the PEI/DNA complexes attach to cell membranes and thenjoin into clumps that are taken into the cell. Once inside the cell, rather thanbeing broken down and used by the cell's machinery, the complexes move into thenucleus, where the desired gene is turned on. The researchers labeled both ......g the gene of interest,penetrates through the cell membranes forced by the electric field. As a resulta gene(s) can be quickly expressed at a place, where no expression is foundduring normal embryonic development. After several days of development,molecular and morphological analysis of the developing structur...Quarterly News Tipsheet -- Research Highlights From Pacific Northwest National Laboratory
... Electrically Switched Ion Exchange, or ESIX, uses membranes coated with asuitable electroactive ion exchange m...rial (nickel hexacyanoferrate forpotassium). The membranes absorb the ions and then, when the polarity of theelectrodes is reversed, the ions are unloaded into...Engineered Bacteria Scavenge Heavy Metals
... seek andtransport mercury through E. coli cell membranes -- as well as genesfrom yeast -- to accumulate mercury inside each E. coli cell. The samestrategy, they believe, can be used to re-engineer E. coli specificallyto scavenge metals such as cadmium, zinc, nickel or manganese, pointing to thesepot...Vastly Different Virus Families May Be Related
...snags the membrane of a host cell and pulls thetwo membranes together so that they fuse into one, like soap bub.... "The mechanism by which the virus causes the two membranes tofuse is turning out to be a good target for inhibitors. There are some peptidesin clinical trials ......d bilayerthat is organic and closely resembles the membranes of living cells. By usingdifferent types of phosph...ry the physical and chemicalcharacteristics of the membranes in a way that mimics the variations found innature, Zare says. The researchers found two ways to use...