Researchers identify important function of NF2 tumor suppressor
...work of filaments that supports the cell. "Since merlin is a tumor suppressor whose loss of function leads...ell-to-cell communications. The researchers found merlin in the adherens junctions of normal cells and discovered that adding normal merlin protein to cultur...A new study reveals an essential role for the merlin protein in maintaining the junctions between cells...ce) in the May 1 issue of Genes & Development. The merlin protein is encoded by the NF2 gene. Mutations in NF2 cause neurofibromatosis type 2, a hereditary ca...... tumor suppressor, merlin, functions. Mutations in merlin cause Neurofibromatosis type 2 (NF2), a common inh...ates the pathway by which cells that are mutant in merlin become tumorigenic. Cell density is one of several growth-limiting parameters. Normal cells prolifer...