How vitamin C prevents cancer--but apples are better
...thesis of amino acids and collagen, wound healing, metabolism of iron, lipids and cholesterol and others. In particular, vitamin C is a well known anti-oxidant that scavenges free radicals." (An anti-oxidant is one of many chemicals that reduce or prevent oxidation, thus preventing cell and tissue damage from...A novel cardiac glycogen storage disease
Glycogen storage disorders are inborn errors of metabolism that typically affect the cellular architecture an...homolog, Snf4, PRKAG2 apparently regulates glucose metabolism by associating with AMPK's catalytic subunits. By introducing the human disease mutations into Snf4,...NSF/EPA team up on grants to treat pollution with plants
...ing the organic chemicals available for uptake and metabolism by plants; and the role of plant-transported oxygen for degradation of organic contaminants in waterlogged, low-oxygen salt marsh sediments or soils. The grants for these studies were awarded through EPA's Science to Achieve Results (STAR) program. ...... destructive free radicals - byproducts of normal metabolism - that disable enzymes and other chemicals. The combination therapy targets mitochondria to get rid of destructive radicals and to boost the activity of a damaged enzyme, carnitine acetyltransferase, that plays a key role in burning fuel in mitochond...Compounds rejuvenate rats, may aid humans
...ee radicals that are being produced as a result of metabolism are actually the same that result from nuclear radiation. Its as if humans were being irradiated throughout their lives. And this process is such a natural part of life that cellular repair mechanisms have evolved to help fix or prevent the damage n...Given the profound effects of insulin on energy metabolism and gene expression in virtually all tissues, it is not surprising that systemic deficiency in the insulin receptor (IR) leads to the early postnatal death of IR?/? mice. However, Cre/lox technology has also allowed for the creation of animals lacki......ge DNA, said Deitrich. This is as a result of the metabolism of alcohol to acetaldehyde. In fact, it is clear ...n if they do not drink, since Antabus inhibits the metabolism of endogenous aldehydes as well? Finally, he added, perhaps the most important future research woul...Researchers develop blood test to diagnose Alzheimers-type changes in mice
...ent is that a simple injection of m266 altered the metabolism of Ab and unmasked important correlations with bra...logy. Hopefully, we also will be able to alter the metabolism of Ab in humans. The team used their data to develop potential models for estimating amyloid levels...Scientist probes fossil oddity: Giant redwoods near North Pole
...e fossils can help them learn how the metasequoias metabolism compared to those of contemporary plants. Did they function similarly to how plants function now? Jahren asks. Or did they have strategies that plants either no longer have or no longer employ? Were they fundamentally different? These fossils are re...Forging a link between brain and bone
...ill, the emerging model of central control of bone metabolism clearly casts the genesis and control of osteoporosis in an entirely new light....U-M scientists find new genetic marker for prostate cancer
...s in men. The protein is an enzyme involved in fat metabolism called a-methylacyl-CoA racemase, or AMACR for short. AMACR has never before been associated with any type of cancer according to Mark A. Rubin, M.D., and Arul M. Chinnaiyan, M.D., Ph.D., the scientists who directed the U-M research study. Results w...Spinal cord injury and Alzheimers risk among topics at American Chemical Society meeting
... The drug, which targets an enzyme involved in the metabolism of excess glucose, appears promising in animal models of chronic diabetes. It is currently undergoing phase II clinical trials in the United States and Canada. (MEDI 22, Sunday, April 7, 3:45 p.m., Convention Center, Auditorium, Level Three) Mo...Defects in 'orphan' inositol polyphosphates may be linked to manic depression, cancer
...uld open the way for defining and correcting these metabolism errors....Tibetans retain resistance to the oxygen-deficient disorder hypoxia regardless of altitude
...to compensate for low oxygen levels and facilitate metabolism and other physiological functions. For the individual permanently residing at sea level, hypoxia can be caused by external factors, such as a sudden arrival in Tibet, or by "internal impairments," within the body where cells receive insufficient ox...Gender differences in fatigue explained by the use of the body's aerobic pathways
...n are better able to utilize oxidative pathways of metabolism to provide the energy for muscle contraction. Efficient utilization of these aerobic pathways results in the production of lesser quantities of metabolic by-products such as inorganic phosphate, which is thought to contribute to muscle fatigue. New...Diabetes tied to altering of the heart's circadian clock
...etes, and the heart's morphology, gene expression, metabolism and contractile performance are all changed in diabetes, researchers investigated whether the clock of the heart is also affected within this environment. The authors of "Alterations of the Circadian Clock in the Heart by Streptozotocin-Induced Diabe...Natural cholesterol-lowerer shows the way
...e drug. Her tests confirmed the lack of effect on metabolism by showing that guggulsterone did not affect the receptor for thyroid hormone, an important metabolic regulator. "While we have seen promising results concerning the drug's cholesterol-reducing ability, there is a lot out there on the Web that we ca...Natural compound used in India reduces cholesterol by blocking metabolism-controlling receptor
...gs would prevent FXR from interrupting cholesterol metabolism in people whose bodies arent getting rid of enough cholesterol before the process shuts down. The gum resin of the guggul tree has been used in Ayurvedic medicine, a traditional Hindu medicine practiced in India for nearly 3,000 years, to treat a wid...Biologists take new look at metabolism
(Santa Barbara, Calif.) Research in metabolism published in this weeks issue of Nature explains that the relation between rates of metabolism and body mass in animals may be more complicated than current models can describe. The authors offer......e most versatile bacteria, capable of adapting its metabolism to highly varied environmental conditions. (3) Most bacterial phytochromes so far identified are active under infrared light, unlike plant phytochromes which sensitive to red light. (4) This protein, termed PpsR, has been isolated from several other ...