Tag: "metastases" at biology news
Genetic Alterations Linked To Cancer In Some Blood Samples
...tionally, the three patients who developed distant metastases
(disseminated cancer) were in the positive test group, further indicating that poor outcome may be associated with the presence of serum DNA alterations. These results must be confirmed in much larger clinical trials, Sidransky says. The technique u...
Maillinckrodt Medical Licenses Invention For Concentration Of Rhenium Radioisotopes
... ORNL for the treatment of bone pain from skeletal metastases
of cancers of the breast, lung and prostate. The clinical application of rhenium-188 for coronary artery irradiation has been approved by the U.S. Food and Drug Administration for use at Columbia University Medical Center in New York. The first pati...
Wistar Research Yields Information About Colorectal Cancer Cell Invasion
...P antigen inhibitstumor cell invasion in vitro and metastases
in vivo. The same in vitro effectsare seen in huma...mmunotherapy works against an antigenthat controls metastases
and kills tumor cells. Obviously, connecting thetherapy success with the function of the antigen is...
Vion Demonstrates Readiness Of First Tumor-Targeting Salmonella For Human Testing Against Solid Tumors
...strated that VNP20009 inhibited the growth of lung metastases
in models of metastatic melanoma and prolonged the life span of animals treated with the TAPET organisms. "These new findings further support Vion's position that TAPET organisms should be safe for use in humans and offer considerable potential as a ...
Non-toxic peptide blocks spread of prostate cancer in rats
...de developed smaller primary tumors and fewer lung metastases
than untreated rats and showed no toxic side effec...er surgery developed 99 percent fewer visible lung metastases
and 95 percent fewer microscopic lung micrometastases than rats treated with surgery alone. Livant ...
AVAX Technologies' M-Vax cancer vaccine induces T cell mediated immune reactions in patients with metastatic melanoma
...tor structure of lymphocytes infiltrating melanoma metastases
after administration of autologous, dinitrophenyl-modified vaccine," showed data that continue to validate earlier results demonstrating that M-Vax elicits an immune response in patients with advanced disease. Most importantly, the data suggest that...
For the first time, scientists uncover how breast cancer metastasizes
...imary tumor. "What this suggests is that the lung metastases
may also have occurredthrough the lymphatic system-they may be going to the lymph nodes and spreadingfrom there," says Detmar. He and Skobe plan to look at different tumors such as prostate and coloncancers to see how much VEGF-C they produce and wh...
Cancer protein chops cell anchors
...eak free. Movement allows the cancer cells to form metastases
in other part of the body....
Researchers reveal new clues about spread of colon cancer
...e cell types; not just the neoplastic cells. Liver metastases
from colon cancers contain a supporting stroma tis..., PRL-3 expression was quite a bit higher in the metastases
than in the primary tumor," said Vogelstein. The scientists also discovered that the higher levels...
PET better at finding recurrent breast cancer
...reas mediastinal lymph node involvement or distant metastases
typically require chemotherapy. The six women with true-positive PET results and false-negative CI were able to receive treatment for their recurrence, such as additional chemotherapy, radiation, and surgery. However, at the end of follow-up, all si...
UT Southwestern, M.D. Anderson researchers identify lung-cancer tumor suppressor genes
...nd allowing them to form tumors around the body as metastases
then introduced the 3p gene therapy in the same fashion. They found that the systemic therapy also was effective in reducing the metastatic tumors. A virus genetically engineered to be harmless was used to deliver the genes. We used Dr. Roths adenov...
Cell Genesys reports long term survival data in Phase II trial of GVAX prostate cancer vaccine
...mone refractory prostate cancer patients with bone metastases
who are treated with chemotherapy, the current standard of care for this patient group. The dose-dependent improvement in survival was consistent with a previously reported improvement in time to disease progression measured by both radiologic and p...
Researchers identify protein linked to tumor invasion
... III ductal carcinoma, who had positive lymph node metastases
at the time of diagnosis. Besides showing a high correlation between tumor aggression and NFAT levels, the researchers showed that NFAT is found in association with another protein, the alpha 6 beta 4 integrin. This integrin has been linked with seve...
UCLA scientists develop prostate cancer tracking system
...hey can locate difficult-to-detect prostate cancer metastases
in laboratory models, a discovery that could lead ..."hot spots," both in primary tumors and in distant metastases
that were still too small to cause symptoms or appear on conventional detection scans. The next step...
New gene may be breast-specific cancer markers
...heral blood and bone marrow; (2) identification of metastases
of unknown origin, and (3) early detection of breast cancer....
University of Pittsburgh Cancer Institute discovers proteins linked to colon cancer
...ve treatment of the disease, however, colon cancer metastases
are very difficult to pick up early. Thirty-five t... the second, we examined the NMPs present in liver metastases
that had resulted from colon cancer. We found that there are several proteins present in the disease...
Targeted radiation to liver tumors spares tissue, improves quality of life
...randomized trial in patients with colorectal liver metastases
conducted by Sirtex, the manufacturer, showed the median survival rate doubled from 12.8 months with chemotherapy alone to 27.1 months with SIRT and chemotherapy. SIRT is another means of attack in the battle against liver cancer. "This is not a cure...
New method for predicting prostate cancer and the risk for metastasis
... a prostate tumor has metastasized was to identify metastases
in other parts of the body. Once a metastatic cancer has spread, intervention to save the patient's life is severely compromised. These new findings were obtained using a technique developed in Malins' laboratory combining highly sensitive and discr...
Scientists find protein that controls prostate cancer's spread
...ived the cells with extra RKIP genes had far fewer metastases
than the mice that received regular metastatic cel...ded RKIP genes, while RKIP was undetectable in the metastases
that grew in either group of mice. The researchers also looked at how well the cancer in the RKIP-en...
Distinctive genetic program guides breast cancer's deadly spread
...ferent cancers, it may be possible to slow or halt metastases
by targeting the proteins produced by those genes....he circulation, the patient only gets a handful of metastases
from these cells. "By contrast, there has been recent evidence that primary tumors that go on to dev...