New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
...study were given colon or breast tumor cells which metastasized to the lung. Some of these cancer cells served as "controls," while other cells were given a protein that specifically inhibited activation of NF-kB, only in cancer cells. The different cells were injected into mice and all were able to establish m...Other highlights in the July 7 JNCI
..., which is only be performed before the cancer has metastasized clinically, as the cancer does not respond to standard chemotherapy or radiation. Cinzia Lanzi, Ph.D., of the Istituto Nazionale Tumori in Milan, Italy, and colleagues tested the effects of the novel 2-indolinone RET tyrosine kinase inhibitor RPI-1 ...Rice and M. D. Anderson establish Center for Computational Cancer Research
...inning with precancerous lesions and continuing to metastasized tumors through treatment and into remission. Analyzing these profiles, researchers can identify the specific mutations that cause different cancers, create tests for each possible variation, and design patient-specific treatments. "The rapid advance ...Breast cancer can be reversed in laboratory mice, scientists report
...gressive mammary tumors; in many cases, the tumors metastasized to the lungs. When the gene was turned off, many of the breast tumors -- including many of the most aggressive and advanced cancers -- regressed to the point that they no longer could be detected by physical examination, magnetic resonance imaging (M...NASA biotechnology activities enhancing quality of life
...bility to maintain bone density in cancer that has metastasized to bone. "OPG appears to prevent bone loss in a variety of diseases, including cancer, and we anticipate that a drug based on this molecule will be effective in preserving bone mass, whether in astronauts or the millions of Americans suffering from o...Researchers discover effective method for killing prostate cancer cells
...lls, reduce the volume of tumors, and kill already metastasized cells." This study was funded by the National Cancer Institute (NCI). Prostate cancer is the second leading cause of cancer death in men, exceeded only by lung cancer. According to the American Cancer Society, prostate cancer is the most common type ...New method for predicting prostate cancer and the risk for metastasis
...ethod for determining whether a prostate tumor has metastasized was to identify metastases in other parts of the body. Once a metastatic cancer has spread, intervention to save the patient's life is severely compromised. These new findings were obtained using a technique developed in Malins' laboratory combining....... The study will focus on cutaneous (skin) lesions metastasized from various cancers such as breast, lymphoma, head and neck and non-melanoma skin cancers. In this Phase I trial, researchers try to determine the maximum dose of the drug that can be tolerated by the patient and toxic side effects related to dosag...Scientists discover gene 'signature' for tumor's tendency to spread
...s (adenocarcinomas) and 12 samples of cancers that metastasized from other adenocarcinomas. This analysis revealed a set of 128 genes whose expression pattern differed between the primary tumors and the metastases. The scientists were puzzled by instances in which the 128-gene signature associated with the metast...An early warning system for dangerous breast cancer?
... tissue), what stage it was in, and whether it had metastasized through the body. The cancerous samples included everything from ductal carcinoma in situ (a low-grade localized condition), to stage IV invasive ductal carcinomas that had spread to lymph nodes or other parts of the body. The wide spectrum allowed t...Old drug shows promise for helping treat advanced lung cancer
...t these stages, the cancer has metastasized - or spread - to other parts o...s to stages III and IV, it has metastasized to lymph nodes surrounding the lungs or to other parts of the body. Researchers ......in cells they microdissected from cancers that had metastasized to the liver. The genetic profile was developed using SAGE (serial analysis of gene expression), a technique invented by the researchers to determine the level of expression of genes. In SAGE, the enzyme, reverse transcriptase, is used to produce com......es, Xiao said. It is very aggressive and often has metastasized to other parts of the body by the time the patients disease has been diagnosed. The statistics are grim: Although more than 80 percent of patients respond to treatment at first, the five-year survival rate for patients whose cancer recurs is only 3 p......re at highrisk -- the majority had tumors that had metastasized to other sites. The 539 children were treated with induction chemotherapy for five months, thensurgery to remove their tumors. The surgery was followed either by astate-of-the-art therapy consisting of three cycles of intensive consolidationchemothe...