Researchers Pinpoint Site For Petit Mal Seizures In Brain
...Previously, the Duke researchers had reported that mice with petit mal seizures have an overabundance of a...at inhibit GABAb receptors control seizures in the mice genetically prone to petit mal epilepsy. The new information will allow the research team to pinpoin...Tumor Suppressor Gene Located In Liver Cancer Cells
...o researchers because it could help to explain why mice appear to be more prone to liver tumor formation t... is especially unusual, because it is imprinted in mice but not in humans. Lacking the back-up that humans have in case one copy malfunctions, mice are mor...Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
...University Medical Center have identifieda gene in mice that, when malfunctioning, causes a joint-destroyi...nflammatory autoimmune response. By comparingtheir mice with other animals that had similar clinical signs, the researchershypothesized the animals were pro...Florida Researchers Discover Gene For Fatal Childhood Disease
... offer genetic therapy for it." People and mice who have Chediak-Higashi syndrome are much moresus...e said. Meanwhile, researchers discovered that mice with Chediak-Higashisyndrome are protected against some forms of autoimmune disease, especiallythe c...Protein Glitch May Be Early Problem In Inherited Alzheimer's
...ael Lee studied presenilin in cell cultures and in mice that contained copies of the human presenilin gene...ease. Hopkins researchers currently are looking at mice in which the gene for presenilin is knocked out so that presenilin's function may be revealed by its......s." Many cancer-causing genesalready identified in mice and otherlaboratory animals are thought tohave ana... that we think of humans asmore closely related to mice than tochickens," Pevzner notes. Even when the starting point ofthe reconstruction was target materi...Pinpoint Gene Control Holds Promise For Nervous System Studies
...of the technology: permanently turning on in adult mice the genefor nerve growth factor (NGF), a substance...ence that kept the genes turned off. Then, whenthe mice were several months old, scientists injected a viralvector that shuttled into the cells an enzyme th...ORNL Mice Helping Researchers Isolate, Identify Causes Of Cancer
...e cancer." Included in ORNL's inventory of 120,000 mice are 1,000 strains, some ofwhich were originally br...st developed, scientists didn't know thereason the mice developed leukemia. Now, however, Justice and colleaguesknow that the mice get cancer because of mur...ORNL Finds Common Genetic Cause For Epilepsy, Migraine
...graine, ataxia andepilepsy, meaning that tottering mice -- aptly named for their lack ofmuscle control -- represent mouse models for both diseases. These models,developed with the help of a human chromosome 19 map from the Human GenomeCenter at Lawrence Livermore National Laboratory (LLNL), are likely to ...Researchers Find Production Point Of Key Protein In Fragile X Syndrome
...mal nerve cells resulted fromstudies of transgenic mice that cannot produce the fragile X protein. Previou...versity in the Netherlandsdeveloped the transgenic mice for the project....Summer Science: Firefly Babies Advertise Their Bitter Taste, UD Researchers Say
...ted theaposematic display theory on ordinary house mice raised in a laboratory. Butfirst, the UD researchers needed to find out whether mice think firefly larvaetaste bad. In previous laboratory studies, vertebrate predators have consistentl...Resistance To Leptin Contributes To Obesity
... regulateits fat stores, contributes to obesity in mice according to the firstformal study of leptin intol...cans, the researchers note. "We knew obese mice and humans generally have high levels of leptinin their blood, which suggested that the protein was ...Huntington's Disease Findings Pave Way For Potential Cure
... Columbia researchers found. Usingnew "transgenic" mice developed by Dr. Bates to contain a disease-causin...e. The NII werepresent in the brain cell nuclei of mice with symptoms very similar to HD andabsent in non-transgenic control mice. "This radically...Jefferson Scientists Find Potential Deadly Effects Of Two Missing Cancer-Suppressor Genes
...Ph.D. and Tina Bocker, M.D., report that female mice that lack a pair of tumor-suppressor genes, p53...R. et al., Cell, 74:1027, 1993). Knockout mice lack a working gene or genes and are used as models to study the effects of cancer gene altera...Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections
... lethal to mice. But when the scientists infected mice with Candida strains with both pathways knocked out, the mice survived and did not succumb to the infection. Based on Dr. Fink's work, other scientists at Purdue ......Cell and detail the increasedlocomotor activity of mice who lack the D4 receptor. "Branching nerve cells ...ne, methamphetamine and opiates. "We examined mice that were genetically engineered to lack the D4dopaminereceptor to investigate the role of this rece...Smoking Mice Lead To Emphysema Breakthrough
...s emphysema, Shapiro and otherscreated a strain of mice that lacked the enzyme. He calls them "mighty mice... it down." Researchers put both the mighty mice and normal mice into smokingchambers twice a day, six days a week. The mice didn't actually have cig...New Form Of Gene Therapy Holds Promise For The Future
...en needed. They have developed a system in mice in which the level of a geneticallyengineered protein responds to inflammatory signals produced by the micethemselves. This method of gene therapy, described in the October issue ofNature Biotechnology, may have great potential for treating chronic r......ose exposed. In the past, researchers have shownin mice that some effects -- in the form of genetic mutati...dreds of thousandsof mice. Hers uses only about 75 mice at a time. According to Wiley, whatis new about her findings is that she saw the radiation effects i...