All Mixed Up: How Do Hybrids Fit Into The Picture?
...sents a different scenario. Her research on hybrid mice reveals thatthey are more prone to parasite attack than their parental counterparts (Mus musmusculus and M. m. domesticus). Her review of the parasitism of animal hybridsnot only suggests an evolutionary implication of parasites. It also stressesth...Heat-Shock Vaccine Stops Bacteria Dead
...en-Waisman and Avi Cohen. The scientists immunized mice with a vaccine composed of a heat-shock proteincar...f a dangerous pneumococcalbacterium. The immunized mice were then infected with lethal doses of thebacteria. Ordinarily, 2-3 bacteria of this type suffice t...Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
...ly short, no recurrence of tumors wasseen in these mice out to 250 days after the last dose of antibody. ...first fully human antibody generated in transgenic mice to be tested in humans. ABX-IL8 demonstrated a three week half life, equivalent to that of naturally......that they identified that themissing gene in these mice was the TLR4 gene, further supporting the conceptthat Toll-like receptors and TLR4 are essential for endotoxin signaling incells. "Still, until now, there were no data showing whether these Toll-like receptors(TLR2 or TLR4) were indeed present in rea...Genetic Research Boosts Understanding Of Iron's Path Through Body, Diseases Of Iron Metabolism
...n by analyzing a legacy of the oldwork: strains of mice dating back to the 1920s and '30s that had defects...iron into allcells of the body, by creating mutant mice lacking the transferrin receptor. The results confirmed their hunch that the transferrin cyc...Researchers: 'Exciting' Discovery Might Improve Cancer Treatment
...cancer genetherapy strategy to block NF-kappa B in mice with a natural inhibitor proteinknown as I-kappa B. Human tumors growing in the mice then became susceptible tochemotherapy and in some cases disappeared altogether following treatment....Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
...ng gamma-tocotrienol for vitamin E in a dietfed to mice slowed the growth of tumors transplanted to those ...noid slowed cancer growth andprolonged the life of mice when fed at a level that an animal might consume. In the current paper, Elson and his graduate stud......9 in non-human primate models. Previous studies in mice have demonstrated that VNP20009 is more than 10,000 times less toxic than the wild-type Salmonella strain from which it is developed. Additionally, the studies showed that the TAPET bacteria were rapidly cleared from the blood to undetectable levels ...Dietary Carotenoid Lutein Reduces Atherosclerotic Lesion Formation In Mice
...ual meeting. "The area of arterial lesions in the mice that were fed chow with lutein wasreduced signific...lipoproteinE (apoE) null mice. Groups of apoE null mice were maintained on a dietcontaining zero or 0.2% (by weight) lutein for four weeks. Researchers the...Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
...ntal Biology 1999 annual meeting. "Tumor-bearing mice that were fed chow containing lutein had significantlysmaller tumor growth than the mice on regular chow," said Boon Chew, Ph.D.,Department of Animal Science, Washington State University. ...The Liver's Secret Of Regeneration
...and oval cells. The researchers irradiated mice to des-troy their bone marrow and thenreplaced it with marrow grafts from other animals whose cells could easily betraced. In one experiment, for example, they gave bone marrow grafts from malesto female mice. Then they damaged each animal's liver an...The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms
...odents treated in thisway are known as 'knock-out' mice because a specific gene has been inactivated (knocked-out) specifically. One fifth of the mice that had their BRCA-1 gene removed from the mammary glandcells developed a tumour within one year. T...Researchers Discover Mechanism Of Cleft Palate Development
...talloproteinases (MMPs). Using "genetic knock-out" mice specially bred without the EGFR, the researcherslearned that after activation of the EGFR, MMPs regulate the closure of thepalate. Palate closure must be closely coordinated with the development of thelower jaw, a process regulated by MMPs. Simply ...Key Peptides Found That Stop -- Even Reverse -- Kidney Disease In Lupus
...sease.Long-term therapy with the peptides in adult mice with established kidneydisease prolonged survival ...ot only arrested butreversed kidney disease in the mice and allowed them to live almost a normallifespan. Datta's group used a special method of adm...Fullerene-Based Materials Clear From Tissue, Go To The Bone
... cancerous tumors. They injected the material into mice and ratsand observed where it went, how long it st...n animals,studying distribution of the material in mice and its metabolism in rats. Wilson and Cagle showed that radioactive fullerenes stay in the...New Way To Modify Mammalian Genes: Honolulu Transgenesis
...u cloning,reported success in producing transgenic mice by injecting eggs in a methodcalled intracytoplasm...uction of transgenic animals isn't new; transgenic mice were firstproduced in 1974, and the prevailing method of producing them by injection ofDNA into the ...Researchers Discover How The Immune System Shuts Down Faulty T Cells
...D 8 cells of that binding bytransferring them into mice engineered to lack class 1 proteins. To their surprise, they found that in both experiments, CD 8 cellsunable to bind class 1 essentially disarmed themselves within 48 hours. That is,the cells initially left the thymus carrying CD 8 proteins...NICHD Researchers Discover Gene For Major Brain Structure
...e layers," saidDr. Westphal. Lhx5 knockout mice provide an exciting model to study in detail how thisgene acts and how its inactivation affects hippocampus assembly and function, headded. This work is part of a concerted effort to unravel molecular mechanismsthat underlie complex brain function, ...Montana Hantavirus Study Looks At Why The Mouse Goes Into The House
... MT--Ask Rick Douglass, a man who has handled deer mice about30,000 times, why the mouse goes into the hou...like symptoms.Humans can catch the virus from deer mice urine, droppings, saliva or nestingmaterials. Ten Montanans have had the disease since it was first ......ity to study the effects of potential therapies in mice proven to have ananalogous chromosomal abnormality...on of its DNA. In the past, scientists would breed mice with suchtraits and hope that perhaps one within a litter of six would be the perfectmodel. But dete...