Jefferson Scientists Develop Botulism Vaccine
...f experiments in which they successfully immunized mice against botulism. One immediate use of a botulism vaccine, Dr. Simpson notes, would be in veterinary medicine. Animals such as racehorses and farmyard chickens are susceptible to the disease, making such a vaccine of interest to the...Human Breast Milk Contains Obesity Hormone
...ore about the protein. The reason is simple: Obese mice that are injected with leptin soon lose their excess weight. Scientists are hoping that by learning more about leptin, they can control the problems of obesity and its related maladies, such as diabetes and heart disease. Karen Houseknecht, assis...Genetic "Short Circuit" Leads To Cleft Palate
...n the form of steroid hormones given to the female mice during pregnancy. This is the first time that a c...clefting, the other strain resistant. Using these mice they have now pieced together a molecular explanation for cleft palate. The genetic circuit that...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...00-fold higherexpression of the gene compared with mice who received injections of naked DNA. The more DNA...njected animals. Whenthe researchers injected the mice with a different gene called luciferasecontained in the RCR structures, they detected high levels of...MIT Biologists Identify Aging Mechanism
...her circular DNAsaccumulate in stem cells of aging mice and humans," the authors wrote. David Sinclair is supported by the Helen Hay Whitney Foundation. The Guarentelab is supported by a National Institutes of Health grant.......iving things -- from bacteria and yeast to plants, mice andhumans. "In the future, human geneticists will think genomically, rather than one geneat a time," said Juergen Reichardt, USC School of Medicine assistant professorof biochemistry and molecular biology and symposium organizer. "Complex humantraits...Chlamydia Vaccine Developed At UMass
...creating a vaccine. MacDonald and Stuart immunized mice with GLXA, and ultimately were able to produce a hybrid cell that produces the correct antibody and reproduces itself endlessly. The body recognizes this antibody as the original GLXA itself. "Essentially, weve created an easy-to-handle prote...Memorial Sloan-Kettering Investigators
... PLZF-RAR . Thedrug combination worked well in the mice resistant to retinoic acid alone (thosewith the PL...F-RAR gene fusion), and was even more effective in mice alreadysensitive to retinoic acid (those with the PML-RAR gene fusion). Indeed, the leukemia cells ...Emory University Fragile X Group Receives NIH Program Grant
...to the syndrome, including cellculture, transgenic mice and yeast systems to help uncover additional answe...lar to FMRP, and a new generation of FMR1 knockout mice in whichthey can closely control FMRP expression, both pre- and postnatally, throughdrug exposure. ...Transgenic Mice Created By Researchers May Shed Light On Human Heart Disease
...arch team has createdseveral strains of transgenic mice that carry gene mutations for a heartdisease that ...tality, she said."We have created these transgenic mice to help us understand the biologicalprocesses and hopefully test new therapeutic agents." My...Salve From Serpents? UD Studies May Explain Why Viper-Venom Protein Stops Tumor Spread In Mice
...hich blocks the "metastasis" orspread of tumors in mice injected with cancer cells, notes Mary Ann McLane,...number of livertumors--from 14.4 among unprotected mice to 0.6 within the treated population,the researchers reported in Experimental Cell Research (Vol. 21...National Toxicology Program Meets On Transgenic Animals
...l discuss the use of gene-modified, or transgenic, mice in screening chemicals for cancer-producing potent... Institute of Health Sciences, Tokyo. Transgenic mice allow scientists to do studies on the carcinogenicity of environmental agents more rapidly than usin......y and permanently separating one group ofimmunized mice from the others, Dr. Heber-Katz's staff pierced th...hat this isclassic epimorphic regeneration. These mice have characteristics, includingtail regrowth and rapid liver regeneration, similar to those seen in ......mutations, it has been possible to developlines of mice that are susceptible to this disease. For example, mice that aredeficient in apoliprotein E (ApoE), an organizing molecule important tolipoprotein clearance...Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
...son, developed the use of theinnovative transgenic mice as a model of photoaging. "We wanted to de...issue," explained Dr. Uitto. "When we exposed the mice to controlled solarsimulating irradiation in the lab we learned from the CAT reporter gene that thel...Genetics May Explain Much Age-Related Hearing Loss
...o'sCenter for Hearing and Deafness. Using mice lacking one or both components of the genes respon...d hearing loss was greater and progressedfaster in mice deficient in the enzyme than in mice with a normal genetic makeupand SOD production that served as a...Long-Standing Puzzle Of Immune System Is Solved By UCSF Researchers
...r researchers conducting experiments on "knockout" mice lackingPms2 found that rates of tumor formation ar...lobulin genes were mutatedat a much higher rate in mice with B cells containing Pms2 compared to micelacking the gene, suggesting that Pms2 somehow acts dif...Scientists Invent Faster Gene Function Identification System
...animals. The scientists chose zebrafish instead of mice because of their fastgrowth rate -- the fish are adult size within 24 hours after they hatch. Andthere is strong evidence of genetic similarities between zebrafish and othervertebrates, including humans, Wagner says. "Scientists are learning...Biologists Map First Gene For Age-Related Hearing Loss In Mice
...gene from anotherstrain with normal hearing to the mice with hearing loss. Thisproduced a genetically simi... andtransmission of nerve signals in the brain. As mice lose theirhearing, it requires a louder audio signal to get a response. Inaddition, James Willott of......eam recently underwentsuccessful vaccine trials in mice at MedImmune Inc., a biotechnology company inGaith... receptors in the bladder. In the MedImmunetrials, mice infected with E. coli did not succumb to disease. "This basicprinciple should be applicable to many ...