Researchers Identify Function Of Brain Receptor Subunit Linked To Memory, Stroke, Dementia
...es where synapses areformed--on the nerve cells of mice lacking NR3A compared with normal mice. These findings suggest that the NR3A subunit may play a protective role,inhibiting the ionic current passed through the NMDA receptor and reducing theamount of calcium entering the nerve cell. NR3A is ...Scientists Discover Proteins Which Help Set The Body's Clock
...l images. There are retinal diseases inhumans and mice which destroy the image-forming layers of the retina but leavethe rest unharmed. Even though victims of these diseases are blind and cannotsee daylight, they still wake up in the morning and go to sleep at night thesame as the sighted. Dr. Sancar bel......B." "Our work extends previous results obtained in mice to a well-defined, naturallyoccurring, large animal model of hemophilia B that is very similar to thedisease in humans," commented Dr. High. "This is the first example of theintramuscular administration of a gene therapy vector resulting in sustaine...Gene May Hold Key To Treating Life-Threatening Cholesterol
...nucleus of liver cells. The researchers engineered mice that lacked LXR-alpha, then fed them diets high in...ithout the receptor, the cholesterol levels in the mice rose so high it destroyed liver function. In humans, excessive amounts of cholesterol cause arterios...Scientists Use Gene Therapy To Correct Deafness In Mice
...tter mates, his mother and father andall the other mice in his ancestral line. Thanks to U-M scientists a... has been passed on to later generations, shaker-2 mice are born with innerear defects which cause deafness and balance abnormalities. In a paper published ...Research Uncovers A Key To Aging And Lifespan Determination
... selectively target cells in the nervous systemsof mice or humans." In addition to developing the necessary tools, the next steps in this field ofresearch will include identifying other types of cells that are equallyimportant in the aging process. Researchers will also attempt to determine ifthere are o...Interleukin-12 Helps Control Mycobacterium Avium Infection
...nfectious Diseases (NIAID)have found that treating mice with interleukin-12 (IL-12) plus conventionalantib...diated immunity. These findings in immunodeficient mice suggest that combined IL-12/drugtreatment may offer a highly effective strategy for managing atypica...Mouse Model Of Down Syndrome Offers Glimpse Into Role Of Specific Genes In TheDisorder
...le to improve the spatial learning deficits in the mice with training. Inmice in the older, Ts65Dn model, the researchers succeeded in reversingneurodegeneration of one form of neuron with the use of nerve growth factor."We have a ways to go," said Epstein, a professor of pediatrics and a seniorauthor of......mal affects of CREB -- is turned on only after the mice mature. The mice are normal at birth, but a few weeks later, mice with the altered gene develop a severe and progress...Vaccine Kills Spreading Cancer In Animal Model
...atic lung tumors in eight of 10 mice, while allthe mice in two control groups that received cancer cells b...tion of the cancercells could cause lung tumors in mice in two weeks. Tests showed the vaccine could prevent this process in a significantportion of...Researchers Show Mechanism And Similarities Of Biological Clocks
...describes the working partsthat drive the clock in mice forward like a watch spring, and in another paperanother team for the first time identifies the gene in fruit flies thatcorresponds to the mammalian Clock gene and shows how it can turn itself offagain, enabling it to oscillate like a pendulum. ...Molecular Key To Heart Failure Development
...ofMedicine, prevented heart failure in a strain of mice genetically engineered todevelop the disease. They...nd Robert Lefkowitz at Duke created two strains of mice having differentbeta-adrenergic receptor system function. One group of these "transgenic" micehad mo...Master Molecule Forms Brains In Frogs And Elbows In Mice
...mately permitting researchers to breed colonies of mice "free" of the particular gene of study and then to observe how the mice fare without it. In the case of the Noggin knockout mice, the answer is: not too well. In fact, mice...Drunken Fruit Flies Reveal Molecular Pathway Regulating Sensitivity To Alcohol
...ilarlyacting, genes in higher organisms, including mice and humans." Ultimately, ofcourse, if these genes do exist in humans the researchers hope to find that theyare linked to alcoholic behaviors. Given how strikingly similar the fruit flies' behavioral response to alcohol isto the human response, said ...Gene Linked To Glaucoma, Hydrocephalus, And Other Birth Defects
... "The gene that we cloned is almost identical in mice and humans," saidBrigid L.M. Hogan, Ph.D., Howard ...ecular Oncology. "We are excited because themutant mice can now be used to understand organ systems in the human." With roots in a classic scientific findin...Feature: Biomaterials Are Transforming Medicine
...a microscopic level. Trials using such a device on mice are underway. With Dr. Henry Brem, an oncologist at Johns Hopkins University, Langerexplored more focused drug delivery for types of brain cancer. Treatmentusually involves chemotherapy, which can have terrible side effects for theliver and...Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
...s of a commonanti-microbial medication can protect mice from otherwise fatal infections with Toxoplasma go...sites extracts. Finally, they tested glyphosate in mice infected with lethal doses of T.gondii. Doses of glyphosate or pyrimethamine that could not protec...Genetic Screening May Be Tool For Selecting Cancer Treatment, Research Suggests
...creatic cancer cells into thethigh muscles of nude mice (specially engineered mice whose bodies do not rejecthuman cells). When the tumors reached a certain size, they were irradiated......s prolonged the survival of the newheart grafts in mice compared with mice who received donor hearts and DCs thathad not been genetically modified with TGF$1. "In anot...