Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
...nly a modest decrease in tumor growth whengiven to mice with large tumors. Radiation therapy alone produce...emonstrating a powerful synergistic effect, evenin mice with very large tumors. "Our finding suggests that radiation therapy, already a standard of cancer c...Researchers Identify A Protein Critical For T Cell Development And Activation
...o limitations, so Koretzky did more experiments in mice in which the genethat codes for SLP-76 was elimina... there is a block in T celldevelopment leaving the mice completely deficient in this cell type," Koretzkysaid. "The conclusion is that SLP-76 is absolutely ...Frequent Genetic Mutations In Hepatocellular Carcinoma
... reached this conclusion after studying transgenic mice programmed todevelop liver cancer: about 50% of the tumors that occurred in these micecontained the beta-catenin gene mutations. Turning to human liver cancer, theresearchers then found that 8 (26%) out of 31 tumors contained malignant cellswith the......hen, to test the immune response, they exposed the mice to lethaldoses of a malignant melanoma cell line that also expresses the Ova antigen. The result: 100 percent of the animals were immune to the melanoma. "In this study, we have shown that peptides derived from proteins expressed bypoliovirus vectors...First Reproducible Cloning Of Mammals From Adult Cells Reported In Nature
...the scientistsused adult mouse cells to create new mice that are genetically identicalto the parent mouse....team created second and third generations ofcloned mice that genetically match their sister/parent, sister/grandparentsand sister/great grandparent. "We su...Defects In Embryonic Development In Lunatic Fringe Knockout Mice
.... Gridley, who has conducted extensive research in mice on the Notchfamily of genes, describes the Notch s...an Zhang ofThe Jackson Laboratory demonstrate that mice homozygous for a targeted mutationof Lunatic fringe exhibit defects in somite formation and in estab...Gene Discovery Provides Insights Into Epilepsy
...arch performed on the mutant "stargazer" strain of mice that serves as amodel for absence epilepsy, HHMI i...be able to open,"Campbell said. "But in the mutant mice lacking stargazin, all of the gates wouldbe able to open. We believe that the increased flow of calc...Stargazer Gene Provides New Clues To Calcium Channel Defects In Absence Epilepsy
...veidentified the gene for the epilepsy mutation in mice known as "stargazer" andreport that the novel gene...vehead-tossing motion and unsteady gait. Stargazer mice have "spike-wave" seizurescharacteristic of absence epilepsy, with accompanying defects in the cereb...Social Stress Causes Dormant Herpes Virus To Resurface In Mice
COLUMBUS, Ohio -- New research in mice shows that changes in socia... In a series of experiments, 40 percent of mice with latent herpes had their virus reactivated when their social structure ...Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find
... either in laboratory studies or inimmunodeficient mice injected with human breast cells that form tumors. The way in which the drugs work is not fully understood, although their successis probably due to their targeting of distinct receptors on breast cancer cellsthat give them an edge over othe...Antisense Therapy Prevents Burkitt's Lymphoma In Mice
...d the cancer returns. In the study, normal mice were injected with Burkitt's lymphoma mousetumor cells. The mice were given complementary DNA therapy for seven consecutivedays. The scientists found that not only d......e intofertilized mouse eggs. They hope to produce mice with propensities towardcancer and neurodegenerative disorders. These mouse models would provide avaluable tool for eventual drug development and continued research on theeffects of Par-4 on cell death. Other University of Kentucky Chandler ...... is true for the Neurospora clock has been true in mice and will probably be true in people. The current work expands investigations of the intricate feedback loop that determines how the circadian clocks operate. The loop relies on levels of the FRQ clock protein that feeds back to shut off activity of......esearchers inserted a defective Caspase-9 geneinto mice and then bred them to produce offspring with two d...optosis was specifically blocked in the transgenic mice deficient inCaspase-9. Experiments also suggested that Caspase-9 is active upstream ofCaspase-3 (a...... heart attack and stroke. The study, conducted in mice and on human platelets, explored the way in whicht...ith platelets lacking PAR3 andfound that while the mice had a markedly delayed and diminished response tothrombin activation the response was not totally ab...University Of Washington Scientists Discover A Gene That Causes Deafness And Dizziness In Mice
...n have identified a gene that, when mutant, causes mice to be deaf andto suffer from motor imbalance. Aptly named, these "deafwaddler" mice lack a protein that transportscalcium ions across the plasma membranes of the hair cells. The hair c...Vertex Researchers Report Three-Dimensional Atomic Structure Of JNK3 Enzyme; Report In Structure
... such asepilepsy. Genomic research has shown that mice bred to be deficient in JNK3show reduced susceptibility to seizure and neuronal cell death. Vertex's has an established track record of applying structural information togenomic discoveries as part of an effort to discover new drugs againstinnovati......perimentalMedicine, reports on the treatment of 21 mice infected with lethal doses of T.cruzi. All of the treated mice were rescued from the infection. A controlgroup of untreated mice all died within four to ten days.......n the south. Alarming brain damage in mice Even very small doses of toxic pollutants ... disturbances in laboratory animals. Ten day-old mice exposed to a few micrograms of DDT will suffer permanent damage to the central nervous system. ......ar, the team has been ableto express in transgenic mice both normal and mutant connexin32 genes inmyelinating cells. This work indicates that these mutations have altered thefunction of the cells and could account for the demyelinating neuropathies seenin the transgenic mice. This research was sup...