New Evidence For Growth Factor Role In Crohns Disease
...her colleagues are studying strains of transgenic mice -- animalsgenetically engineered to overproduce IGF-I in cells that are involved in thefibrosis of CD. "Then if we experimentally give them bowel inflammation, do weget this excessive fibrogenic response?" she asks. The UNC researcher speculat...UCSF Researchers Identify Molecule Involved In Early Stage Of Atherosclerosis In Mice
... Charo's team examined the outcomes in two sets of mice that were geneticallyengineered to be highly susceptible to atherosclerosis. One group of mice wasalso missing the receptor (CCR2) for MCP-1 on monoctyes that allows MCP-1 tohave an effect. Both...Snake Venom Slows Tumor Growth
...world's largest scientificsociety. In studies with mice implanted with human breast cancer cells, Markland'sresearch group found a 60 - 70 percent reduction in the growth rate of thebreast tumors and a 90 percent reduction of tumor metastasis to the lungs ofanimals treated with the protein contortrostatin...Laboratory mice genetically engineered to have human apolipoprotei...Theresearchers then observed the behavior of these mice in a variety of controlledlaboratory situations that require specific cognitive skills. The ......off was the first to producegenetically engineered mice without the p27 gene. Studies on the "null" miceindicated that p27 played a major role in the cells' response to signals tostop cell growth and promote growth arrest. They developed prostatic hyperplasiasimilar to that found in human males, producin......brakes on TNF. Using genetically modified mice with a specific gene removed,researchers at the Na...n previous experiments, the researchers found that mice geneticallymodified to remove the TTP gene suffer many ailments similar to those associatedwith over...Sperm Protein May Hold Clues For Fertility And Contraceptives
.... The researchers studied the activity of sperm in mice lacking the gene forfertilin-beta, which belongs t...e important in cell binding. Sperm from the mutant mice looked and moved normally, but most of them failed toattach to the egg. These sperm fused with the ...MicroCAT A Welcome Sight To Geneticists And Mice
... tool to examine softtissue and skeletal detail of mice and other laboratory animals -- withoutkilling the... means we can survey many offspring of mutagenized mice for organ orskeletal abnormalities and for changes that occur as a mouse ages or is exposedto differ...Could A 'Vaccine' Made From Our Own Cells Work Against HIV?
...od ofimmunisation. A team in Montana has immunised mice against Chlamydia, abacterium that can cause infer...ferent approach. They took bone marrow from female mice and cultureddendritic cells by adding interleukin-4. Dendritic cells recognise foreignmolecules and ...Paradoxical Gene Suppresses Tumors Yet Makes Them Grow
...occurs rarely in people. Some of these"transgenic" mice were selectively bred not to have E2F1. "We found ...it," the Carolina researcher says. "E2F1-deficient mice developnormally and live long lives." The study authors say it will be important to determine if E2F...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
... of bacterial growthin vitro and the protection of mice against a lethal infection by the regulatedintrace...s growth, then its inhibition should allowinfected mice to survive an infection by that pathogen, when they would normallydie. By observing direct results i...Anti-Microbial Agent Kills Influenza Virus
...assages offour groups of laboratory mice. Control mice in Group 1 were given ordinarysaltwater. Group 2 ...P. Groups 1, 2 and4 stayed healthy, while all the mice in Group 3 developed severe pneumonia andtwo out of three mice died before the conclusion of the stu...New Anti-Microbial Agent Destroys Anthrax
...estroyanthrax spores both in a culture dish and in mice exposed to anthrax through askin incision. James ...rge amounts of BCTPto laboratory rats and injected mice with the material subcutaneously. Theanimals gained weight, remained healthy and suffered no advers...Antioxidant Action Of Vitamin E Significantly Reduces Heart Disease In Mice
In mice genetically manipulated to develop atherosclerosis... tissues was limited by about40 percent in at-risk mice receiving doses of the vitamin for only 16 weeks. The researchers were also able to show tha...Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
...eneration and controlled tissue growth. Because mice are genetically similar to humans, they are an ide...n, Dr.Heber-Katz and her group cross-bred "healer" mice with non-healers. It appearsthat, in inbred mice, this type of healing is a heritable trait. By scr......estigatorswere not surprised that sperm from these mice were unable to fuse with eggs. However, they did n...astulas are then surgically introduced into female mice that serve assurrogate mothers. Some of the offspring born two and one-half weeks later are ...Mouse Model For Huntington's Disease Developed By NIH, Vanderbilt
...athologist, have geneticallyengineered and studied mice that mimic the behavioral and pathological changes... theneuropathological changes in the brains of the mice and found them to be similarto those seen in human Huntington's disease. "The striking thing...Fewer Songbirds May Be Result Of Forest Fragmentation Across The American South, New Study Suggests
...rizing predators as small-mouthedlike chipmunks or mice or larger, and we used clues in the depredated nes...redators, the researchers gave clay eggs tocaptive mice to study the tooth and claw marks they made on them. Bill markswere compared to the bill dimensions ...UCSF Finding Offers Insight Into Way Genes Regulate Aging And Life Span
...w-calorie diets. As with C. elegans, when rats and mice are fed low calorie diets they livelonger than normal, and the first response they have on the molecular level is adrop in insulin levels. The equivalent of the daf-2 gene in humans produces thecell receptor for insulin and insulin-like growth facto....... In the study, the researchers found that mice bred without D2 dopaminereceptors voluntarily dran...ction of alcohol while the locomotion of themutant mice did not change," says Phillips. "In addition, the normallittermates show increased stumbling and th...