Mice Lacking Gene Show Reduced Alcohol Preference And Sensitivity
... journal Nature Neuroscience shows that laboratory mice bredwithout a functional gene associated with the ... The laboratory experiment involved placing mice in a cage with twobottles in it -- one filled with water, the other with ethanol. To make sure themi...Oxygen-Carrying Myoglobin Not Necessary For Survival
...s made theirbreakthrough by developing a strain of mice lacking the gene to producemyoglobin, which transp...ed for contraction of the heart, we predicted that mice could notlive without this protein," said Dr. Dan Garry, assistant professor of internalmedicine and...... strong asfor clear evidence. The studies in male mice were determined to be inadequatedue to an infection; ethylene glycol monobutyl ether, or 2-butoxyethanol, used in latexpaint, and paint thinners and strippers, and many industrial and householdcleaners. The studies demonstrated "some......progress. Instead, Rostami's team waited until the mice had their first relapsebefore administering the ex...atment afterthe onset of a relapse. "Those mice that received the antibody to interleukin-12 didn'trelapse," notes Rostami. The same results hold t...Viral Vector Delivers Dystophin Gene To Mouse Muscle
...ver the gene for dystrophin to the muscles ofadult mice with muscular dystrophy without triggering their i...hin protein in an immuno-deficient strain of adult mice withDuchenne muscular dystrophy. At this year's meeting, Giovanni Salvatori, Ph.D.,post-doctoral re...Mouse Study Trumpets New Way To Preserve Species
...iable eggs in immune-compromised mice, a strain of mice that can readily accept foreign tissues because it...iments, cryopreserved ovarian tissues from outbred mice or sheep were transplanted into immune-compromised mice. After hormone production was established, t...Hopkins Research Team Cultures Long-Awaited Human Embryonic Stem Cells
...ails, and while scientists have found stemcells in mice and higher animals, this is believed to be the fir...ywe couldn't before. Instead of having to rely on mice or other substitutes forhuman tissues, we'll have a unique resource that we can start applying tomed...Duke Scientist Reports Advances In Gene Therapy For Heart Failure
...ue. In 1994, Duke researchers showed that mice genetically altered toproduce excess beta adrenergic receptors (bARs) have supercharged hearts thatbeat faster and stronger than a normal mouse's heart. In 1997, the researchersinserted a gene that encodes the bAR into an adenovirus, the same virus t...A Protein Switch May Turn On Heart Cells To Combat Heart Disease
...eart sizes between the genetically altered miceand mice who still had the Rb gene on in their hearts. Scie...divide for a longer time inthe genetically altered mice (those without the heart Rb gene). At eight weeksof age the hearts in mice without Rb were 8 percen...When One Gene Has Two Roles, Its Second Function May Be Missed
...ouspitfall to a powerful experimental technique in mice that scientists have usedfor a decade to try to un...oth copies of theGATA-2 gene. "These gene-knockout mice die early in embryogenesis," Engel said. The GATA-2defect is unknown in humans, he said, presumably ...Scientists Find First Protein In Central Nervous System Junctions
... molybdenum. When the protein is missing, mice display symptoms of twolife-threatening human dise..., Feng and Tintrup inactivated thegephyrin gene in mice and studied the outcome. Mice that lacked both copies ofthe gene failed to cluster the glycine recep...Molecular Mission Unveils New Genetic Link To Common Birth Defect
...sm make blood, since when researchers firstcreated mice that lacked the GATA-2 gene, the inability of the mutant mice tomake blood caused them to die in utero. Using a new genetic technique, Dr. Engeland his group have...New Company Formed Through Licensing Of Cardiac-Hypertrophy Technology From Texas Institutions
...ment and the development of genetically engineered mice that mimic humanheart disease, represent powerful ...sporine A and FK 506, could prevent hypertrophy in mice by targetingthe enzyme calcineurin. At last week's American Heart Association meeting inDallas, Olso...Scientists Finger A Molecular Kingpin In Body's Response To Cigarettes
...or thearomatic hydrocarbon, or AH, receptor; these mice had no damagefrom the same levels of cigarette smo...more than 4,000 chemicals; animals like humans and mice breaksome down into harmless byproducts and turn others into moredangerous compounds that wreak havo...Discovery Of Mutation May Lead To Help For Male Fertility Problems
... The researchers found no abnormalities in the mice except that they wereinfertile; the animals looked and behaved normally, including their matinginstincts. Although they formed precursor cells for normal sperm production atbirth, by about 10 days old -- puberty in a mouse -- the cells began dying. B...Shedding Light On Circadian Rhythms
...ms,Takahashi's and Sancar's research teams created mice that lacked the Cry2 gene.The researchers then used these mutant mice to measure whether the absence ofCRY2 affected expression of another gene, called mPer1, that is kno......ncentrations of a neurotransmitter in thebrains of mice are directly related to alcohol consumption and re..., the UW scientistsreport that genetically altered mice that do not produce the naturally occurringbrain chemical or neurotransmitter called neuropeptide Y ...Jefferson Scientists Use Gene Repair Technique To Change Albino Mice Cells To Black
...tion in the gene that controls skincolor in albino mice cells. The alteration, known as a 'point mutation,' was inthe gene for a key enzyme, tyrosinase. Tyrosinase is involved in making melaninand in pigmentation. By correcting the alteration, tyrosinase activity wasrestored and melanin was again produced......wn that levels of AGRP areabout ten-fold higher in mice which are genetically obese, or have fasted. Whileno studies have been reported yet on the levels of AGRP in humans, previousresearch by other groups shows two genes that interact with AGRP in thispathway (those for alpha-MSH and the melanocortin-4 r...... some way. Also, they knew that laboratory mice engineered to develop amyloidplaques to the exclusion of the tangles do not lose neurons nor do they developdisease. In contrast, the tau tangles are signature features in FTDP-17 whilethe amyloid plaques are not present, yet neuronal death and disea...