Could A Nasal Vaccine Finally Get Rid Of The Black Death?
NOSE drops can protect mice from bubonic plague, the disease that wiped out at...reaching their target. The researchers say mice whose noses and throats were treated with thevaccine were fully protected from inhaled Y. pestis (Va...Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain
...sts designed to test levels of anxiety, the mutant mice displayedbehaviors suggesting they were significan...ompare the behavior of the mutant micewith that of mice treated with antidepressant drugs. While they stress thatfurther studies are needed to confirm their...Gene Discovery Paves Way For Preventing Deadly Bacterial Shock
...nfection. "The knowledge that these mutations make mice highly susceptible to certainbacterial infections puts us in a position to identify comparable mutations inpeople to determine if they also are predisposed to these diseases," said Dr.Bruce Beutler, professor of internal medicine, Howard Hughes Medic......increase instrength over untreated muscle in these mice -- fully restoring their strengthto what it was in young adulthood. The technique suggests human therapies that could reverse the feeblenessassociated with old age or counter the muscle-wasting effects of musculardystrophies and related disea...Brain Building May Depend On DNA Cutting And Pasting
...ive at their findings, Alt and his colleagues bred mice lackinggenes for the two paste proteins, XRCC4 and... severeimmunological deficiencies, both strains of mice displayed holes in regions oftheir brains, signifying areas of cell death. Overall, the defects were...Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
...ich control the movement of voluntary muscles. The mice exhibitprogressive paralysis that initially begins with the hindlimbs. Variableforelimb paralysis occurs in later stages of the disease, with life expectancyrarely exceeding four weeks. Similar motor neuron degeneration is implicated in amyot......ues. "Administration of these modified bacteria to mice bearing melanoma tumorsresults in tumors that are ...m. • Injection of the mutated Salmonella into mice and swine caused no deaths,while administration of wild-type bacteria produced mortality in all of t...Gene Therapy Incorporates Molecular Rheostat For Controlled, Long-Term Drug Delivery
...e. A report on the experimentalstudy, performed in mice and monkeys, will appear in the January 1, 1999, i... switchused with some household lights. In mice and in rhesus monkeys, giving more rapamycin stimulated aproportionate rise in production of Epo, re......iationof embryonic cells, eventually rendering the mice sterile. In one of the major achievements ...archerRichard N. Yu ultimately generated XY and XX mice that carry the mutant AHC genethrough the use of a sophisticated gene excision and recombination tec...Serotonin May Be Better Target For Attention Deficit Hyperactivity Disorder Treatment
...e only key to understandingADHD, so they turned to mice in which they had "knocked out" the gene that code...dopamine from the synaptic cleft, thebrains of the mice are flooded with dopamine. The excess dopamine causesrestlessness and hyperactivity, behaviors that ...National USDA Center For Food Gene Data
... structures in genome databases of plants, humans, mice and other lifeforms. Similar structure often connotes similar function, and now it will takescientists less time to learn how a gene performs. Once a gene's function, suchas disease resistance, is identified, biotechnologists can begin experiments ...Fool An Egg Into Thinking It's Fertilised, And It Will Repel All Comers
...ical sperm surface protein called fertilin-beta.In mice with a faulty fertilin-beta gene, sperm rarely fuse with eggs. The teamsynthesised the part of the sperm protein thought to bind to the egg, attached aradioactive tag, and then mixed the tagged peptide with mouse eggs. The tagged fragment ...Adult Cells Undergo Identity Switch Reported In Science
...nsplanted adult stem cells from thebrains of adult mice into the bone marrow of new mice, where the stem c...ause they come from humanembryos. Now, a study on mice by Angelo Vescovi, of NeuroSpheres Limited in Canada andthe National Neurological Institute in Italy...Human Neural Stem Cells Advance Distant Prospect Of Reseeding Damaged Brain
...r years has helped finance and publish his work on mice by arguing thatit might yield important insights i...that the stemcells restored a brain area in mutant mice whose cerebellar granule neurons donot develop properly. In all those experiments, the graf...Encouraging Results In Preclinical Studies Of Parkinson's Disease Gene Therapy
...ingle gene therapy injection, genetically modified mice exhibiting certain symptoms of Parkinson's disease...ion of the study. Without L-dopa treatment, these mice die of malnutrition by three weeks of age. An adeno-associated viral (AAV) gene delivery system was...Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
...red muscle-derived cells intomuscles of SCID mice, mice that do not reject the normally foreign-looking ce...estigators examined thetreated muscles in the SCID mice and discovered that the injected cells werecapable of participating in bone formation. The investiga...... The researchers discovered the Hephaestus gene in mice with iron deficiencyanemia, and determined that th...copper. (Congenital deficiency of ceruloplasmin in mice and humans leads to ironmetabolism defects, including iron accumulation in multiple visceral tissues......other words, the receptor mechanism is the same in mice as inpeople. The discovery itself was made possible by a method, refined by Tailor,for cloning the receptors relatively quickly. "The basic technique we are usingis to isolate a gene from a cell which is susceptible to the virus and express ...A New Encyclopedia Of Mouse Genes
...se from various adult mouse organs as well as from mice in the earlieststages of development. "The mouse p...ry point." Another thing that scientists can do in mice is "knock-out," or inactive, agene to try to determine its function. Today, researchers routinely cr...Fly Tumor Points Way To New Understanding Of Cancer Development
...the LATS1 gene in mice. The scientists found that mice developed ovariantumors, soft-tissue sarcomas and ... the LATS1 gene, although the correlation between mice and humans is not thatgood in terms of the types of tumors caused by a particular mutation." In a c...