Gene Knockout Prolongs Ovarian Lifespan In Mice
... found thatinactivation of a single gene in female mice can sustain ovarian function intoadvanced age. Th...ruary issue of Nature Genetics describes howfemale mice in which a gene called Bax is inactivated do not experience thenormal loss of ovarian cells that occ...Growth Factors Improve Muscle Healing In Animals
... both gastrocnemius(calf) muscles of 42 mice. The mice were then divided into three sets of 14apiece. Each set received a different growth factor, either insulin growthfactor type (IGF-1), basic fibroblast growth factor (b-FGF) or nerve growthfactor (NGF). One gastrocnemius muscle in each mouse served......analyzed bone tissue at the fracture site in adult mice at 3, 6,8, 10, and 14 days after fracture to assess the presence of growth factors andother proteins. The UCSF team is believed to be the first to report theexpression of the two genes in an animal bone repair model. "Understanding this cascade of......rrow.The research was conducted in immunodeficient mice transplanted with human stem cells. "In the future, this approach might improve the success rate of human bonemarrow transplantation," Dr. Lapidot says. He conducted this research with histeam members Drs. Amnon Peled, Isabelle Petit and Orit Kollet,...UCSF Researchers Pinpoint Molecule That Triggers Deadly Progress Of Pulmonary Fibrosis
...role of the integrin was confirmed in studies with mice lacking thegene for this protein -- so-called genetic knockout mice. The team showed thatin mice lacking this gene, the lungs do not develop pulmonary fibrosis inresponse to a drug that normally in......py of a certain region ofchromosome 11. Studies in mice linked the chromosome region, called LOH11A, withthe ability to slow tumor growth. In LOH11A, he suspected, lay a generesponsible for the aggressive nature of lung cancer, a gene whose remainingcopy could no longer prevent the tumors' spread from th...Duke Scientists Engineer 'Stealth Virus' To Deliver Genes
...searchers injected this engineered adenovirus into mice withintact immune systems, "within three days, the modified virus had infected everysingle liver cell," Amalfitano reported. Since the liver screens all bloodwithin the body, adenovirus infections tend to concentrate in that organ, hesaid. Subsequen...Allelix Clones Receptor For Intestinal Growth Factor GLP-2
...ed the regeneration of intestinal mucosal cells in mice withchemically induced colitis. "Our observations suggest that administering ALX-0600 to enhance normalmechanisms that regulate intestinal cell growth may be a useful adjunct fortreating the intestine in the presence of active inflammation," noted D...NYU And Rockefeller Scientists Design Molecules That Stymie A Notorious Bug
...ere able to dramatically weaken Staphinfections in mice who had large abscesses on their backs caused by thebacteria. The abscesses became dramatically smaller in animals treated withspecific inhibitory peptides compared to those in untreated animals, indicatingthat the inhibitor had weakened the bacteria...Researchers Identify Gene That Sets Boundaries For Heart Chamber Development
...lsofound Irx4 to be localized in the ventricles of mice and zebrafish. Studying Irx4 may also shed light on the cause of certain heart defects."If we have a full understanding of heart development and function, we willbetter be able to deal with heart disease," said Cepko....Gene Orchestrates Heart Chamber Development
... The researchers also found that a similar gene in mice shows the same type ofexpression pattern in ventricles. Since mice and chickens have such similargenes, Cepko says that she expects to find some close homologues in ot...Researchers Isolate Gene For Heart And Facial Defects
...n studying cardiac development,noticed that mutant mice with improper heart development had characteristic...those found with the chromosome 22 deletion. These mice lacked asmall protein and also had a less-than-normal amount of an important cardiac-gene regulator,...Brief Exposure To High Temperature Has Lasting Effect On Nervous System
...e in invertebrates. "If we see the same effect in mice we can start tryingto figure out exactly how heat shock plays this protective role," says Ramirez. "Then we might be able to mimic those protective effects in cases where thenerves are undergoing trauma, like in stroke patients where the nerves arest...Knockout Mouse Reveals Genetic Mechanism In Defective Mammalian Ear Development
...t year on developmental defects inJagged2 knockout mice from The Jackson Laboratory. He describes the path...Kelley and Gridley and their colleagues found that mice withoutJagged2 exhibit a significant increase in hair cell density compared with normalmice, and hav...Researchers Find Fas Ligand Is Important In Blinding Disease
...and Kaplan took their experiments into a strain of mice used to studyinteractions between the two proteins...del of macular degeneration,they found that if the mice were deficient in Fas or FasL, there was a largeincrease in the growth of new retinal vessels. ...Heart Disease Symptoms Worsen When Body Tries To Adapt
...dthe heart pumping action of healthy young and old mice to those of same-age miceharboring a defective gen... While the hearts of both younger and older mice with FHC had theidentical gene defect, they performed differently. Both contracted faster butrelaxe...Mechanism For Fungal Adherence Found, Possible Key To Disease
.... Theyinjected one group of mice with Candida strains with the transglutaminase-binding protein intact and anothergroup with Candida lacking the protein. Mice in the first groupquickly succumbed to the infections w...Telomere Loss Spells Trouble for Aging Mice
...re-deprived newborns. Forexample, third generation mice displayed symptoms only after they had reachedthe ... Even the most telomere-deficient sixth generation mice hadto go through a waiting period, albeit shorter, before symptoms appeared. In this and oth......iet with the same amountof calories. In contrast, mice with a normal mg gene gain excess weight on thehig...uced obesity in which weight gain occurs even when mice are fed anormal diet. Genetically induced obesity in mice has been linked to mutationsin the obese ...