Tag: "microarrays" at biology news

UCSF scientist Joe Derisi named MaCarthur Fellow

... to drugs. DeRisi, who designs and builds microarrays -- a technology in which gene activity is revealed...cuses much of his energy on using his custom-built microarrays to move in on viruses that cause a variety of infectious diseases. In January 2003, he and his then-...

'Gene chips' research in cotton could lead to superior variety

...ants as a model system. Chen's work involves DNA microarrays or "gene chips." In his laboratory, by spotting DN...ly 30,000) of an animal or plant genome. "DNA microarrays have broad applications in studying changes in gene expression and genomic structure in many biologi...

Scientists decipher genetic code of biothreat pathogen

...AS). As part of the study, scientists used DNA microarrays to better understand the functions of B. mallei virulence genes. Nierman, an investigator at The Institute for Genomic Research (TIGR), said the new study, along with a report on the related bacterium B. pseudomallei published in the same issue of PN...

5AM Solutions releases Microarray Enterprise Manage(TM) Software

...ch will eventually lead to cures. While expression microarrays are now a common genome-scale tool used widely in research, the vast amounts of data created by this technology at distant sites are rarely combined - slowing the progress of medical research. Collaboration and consortia, key elements of the National...

Microarrays, key genome expression trackers, work better when probes are sequence-verified

...his study, they undertook a global analysis of the microarrays and systematically attempted to confirm the accura...y. They note that the leading manufacturer of such microarrays "apparentlyhas come to the same conclusion and has recently released a platform containing RefSeq-ve...

MIT technology jump-starts human embryonic stem cell work

...o incubate. "We can simultaneously process several microarrays under a variety of conditions," Anderson said. Another plus: the microarrays work with a minimal number of cells, growth factors and other media. "That's especially important fo...

From lung to gut the Wnt signaling pathway transforms cell fate

...coding secretoglobin and surfactants. In addition, microarrays comparing the transgenic cells with normal lung epithelial cells showed a general reduction in the expression of lung-specific genes and a strong expression, instead, of genes characteristic of intestinal cells. "A striking feature of the microarray ...

Other Highlights in the June 2 JNCI

...l School in Ann Arbor, and colleagues used protein microarrays to look for an immune response to AMACR in patient...ponse to cancer-specific antigens by using protein microarrays could lead to improved biomarkers of disease." Contact: Sally Pobojewski, Senior Science Writer, Un...

Setting the gene expression base-line for breast cancer research

...tempted to identify gene expression changes, using microarrays or 'DNA chips', in order to understand and predict breast cancer onset, progression, and clinical outcome. Although important insights into breast cancer have been drawn from determining the expression 'profiles' of thousands of genes in tumors, the ...

Gene-based screen sorts cancer cases, say Stanford researchers

...RT-PCR for other disease tests. Levy said although microarrays and RT-PCR give similar information, the new test is more likely to become widely used if it is easy to incorporate into existing medical labs. "You want to introduce something that helps people do what they are doing now - but better," he said. He a...

New diagnostic tool brings effective treatment closer to patients

...drugs and the associated side effects. The use of microarrays will be able to predict relapse or metastatic disease in patients treated by the current standard of care, therefore sparing selected patients from chemotherapy or closer monitoring and/or dose intensification in patients at high risk. The informati...

Light Biology, a biotech company based on UT Southwestern technology, bought by NimbleGen Systems

...al film processing to manufacture specialized DNA microarrays more quickly and cost effectively than previously ...opment at UT Southwestern. Dr. Garner said, "These microarrays can monitor levels of every gene of an organism that is expressed in a disease. And the technology c...

DNA chip will catch beefed up chicken

... larger number of species. Affymetrix expects its microarrays to become the "Intel chips of microbiology", and is developing similar devices with Roche Diagnostics of Switzerland to diagnose human cancers and viruses such as HIV....

Mouth microbes may help shape immune system, says Stanford research team

...investigator Patrick Brown, MD, PhD, on developing microarrays - glass slides carrying thousands of DNA spots, each representing a different gene - to screen samples for thousands of micro-organisms at once. The hope is to discover the relationship between human gene expression in subgingival tissue and the micr...

New findings are a window into the late stages of 'Lou Gehrig's' disease

...otal RNA. DNA microanalysis was performed with the microarrays representing approximately 6,800 human genes. Scanned image files were converted to mRNA expression levels using software programs. To generate a discriminatory gene list, all genes with maximum intensities below a value of 1500 across all samples we...

Scientists report first sequencing of environmental genome

...ommunity structure over time, and to construct DNA microarrays to monitor global community gene expression patter... team. With the genes in hand, they plan to create microarrays - so-called gene chips - to determine how gene expression and protein production change with changin...

Researchers develop computer application to 'read' medical literature, find data relationships

... "Many new high throughput technologies, such as microarrays for gene expression analysis, generate so much data that it is often hard to interpret," Dr. Garner said. "IRIDESCENT can do a much better job because it emulates the scientific thought process. Having assimilated all of MEDLINE, IRIDESCENT can compi...

Researchers identify molecular cause of drug-resistant prostate cancer

... only in drug-resistant prostate cancer cells. DNA microarrays measure the relative levels of gene expression in cells. Before the researchers could look for genes that are switched on in drug-resistant cells, they first used a technique called xenografting to establish hormone-sensitive human prostate cancers ...

A first glance at global genetic networks

...ve model that integrates gene expression data from microarrays with genomic sequence information to explore genetic networks. Analyzing the gene expression profiles of six distantly related organisms--bacteria, yeast, plant, nematode, fruitfly, and human--the researchers found that functionally related genes wer...

Ultra-thin coating traps DNA on a leash

...to attach in three different places could make DNA microarrays denser and more affordable, according to Penn Stat...arge numbers of DNA fragments, researchers use DNA microarrays sometimes called biochips or genome chips. Currently, manufacture of these chips is time consuming...

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