CNS cell death in bacterial meningitis
...le neurons and glia. Braun et al. have established microglial and neuronal cell culture systems in which to study the mechanisms by which Pneumococcus bacteria induce cell death. In a recent paper in the Journal of Infectious Disease, these same authors showed that exposure to these bacteria induces a caspase-i......HC class II molecules in neighbouring microglial cells. The data suggest that neurotrophins acting ...they are induced, most prominently in microglial cells that represent the major APC of the brain. Not only inflammatory lesions to the b......st the nitric oxide might be involved in the rapid microglial accumulation that follows injuries to the connectives. Sahley and Shafer cultured some of the pinched connectives in the presence of an NOS inhibitor to see what happened when the signaling process was blocked. After 24 hours of regeneration, the gro...